Incidental Mutation 'IGL01714:Olfr1061'
ID104877
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1061
Ensembl Gene ENSMUSG00000075185
Gene Nameolfactory receptor 1061
SynonymsMOR188-9, MOR188-1, MOR188-7, Olfr1515, GA_x6K02T2Q125-47883395-47882454, MOR188-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.107) question?
Stock #IGL01714
Quality Score
Status
Chromosome2
Chromosomal Location86413109-86414050 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 86413800 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 84 (N84S)
Ref Sequence ENSEMBL: ENSMUSP00000097474 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099889]
Predicted Effect probably benign
Transcript: ENSMUST00000099889
AA Change: N84S

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000097474
Gene: ENSMUSG00000075185
AA Change: N84S

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-51 PFAM
Pfam:7tm_1 41 291 2.2e-17 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T C 8: 72,455,569 probably null Het
Acvrl1 T A 15: 101,137,370 I259N probably damaging Het
Ahctf1 A G 1: 179,795,877 S59P probably damaging Het
Bcas1 T C 2: 170,384,182 probably benign Het
Ccdc33 T C 9: 58,029,870 N682S possibly damaging Het
Celf1 T C 2: 91,009,207 S326P possibly damaging Het
Cntn1 T A 15: 92,253,989 C436* probably null Het
Cyp2d40 T G 15: 82,761,240 D142A possibly damaging Het
Dnhd1 C T 7: 105,720,942 L4525F probably damaging Het
Drosha A G 15: 12,878,784 Y732C probably damaging Het
Edn1 A G 13: 42,305,014 N101S probably benign Het
Faxc C T 4: 21,936,688 P108S probably damaging Het
Glb1l2 C T 9: 26,768,418 probably null Het
Gm20498 A G 12: 81,510,890 I47T probably damaging Het
Gm4952 G T 19: 12,624,711 R161L probably benign Het
Hipk2 A T 6: 38,819,182 Y51N probably damaging Het
Id4 T G 13: 48,261,790 I98S probably damaging Het
Klf6 T C 13: 5,866,659 S268P probably benign Het
Kmt2c G T 5: 25,313,400 T2427N probably benign Het
Lrp3 T G 7: 35,206,071 probably null Het
Lrrc66 A G 5: 73,629,977 I10T probably benign Het
Mapkap1 T G 2: 34,518,843 V281G probably damaging Het
Ncor1 T A 11: 62,334,584 I1054F possibly damaging Het
Ppp1r9b C A 11: 95,005,354 T817N probably damaging Het
Prkd2 T A 7: 16,863,942 I659N probably damaging Het
Radil T C 5: 142,543,397 probably benign Het
Smarcd1 C T 15: 99,712,421 T474I probably damaging Het
Srd5a1 C T 13: 69,611,062 W62* probably null Het
St5 A G 7: 109,570,062 S9P probably damaging Het
St6galnac2 C T 11: 116,685,119 D169N probably damaging Het
Ttn T A 2: 76,857,179 probably benign Het
Vmn1r77 A T 7: 12,041,350 I18F probably benign Het
Xrcc5 A T 1: 72,329,984 K332N probably damaging Het
Other mutations in Olfr1061
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01721:Olfr1061 APN 2 86413333 missense probably damaging 1.00
IGL02696:Olfr1061 APN 2 86413615 missense probably benign 0.03
R0366:Olfr1061 UTSW 2 86414025 missense possibly damaging 0.71
R0607:Olfr1061 UTSW 2 86413170 missense probably damaging 1.00
R1013:Olfr1061 UTSW 2 86413975 missense possibly damaging 0.61
R1017:Olfr1061 UTSW 2 86413511 missense probably damaging 1.00
R1617:Olfr1061 UTSW 2 86413691 nonsense probably null
R1690:Olfr1061 UTSW 2 86413954 missense probably benign 0.03
R4126:Olfr1061 UTSW 2 86413224 missense probably damaging 0.99
R5053:Olfr1061 UTSW 2 86413338 missense probably damaging 1.00
R5443:Olfr1061 UTSW 2 86413593 missense possibly damaging 0.54
R6195:Olfr1061 UTSW 2 86413207 missense probably damaging 0.98
R6233:Olfr1061 UTSW 2 86413207 missense probably damaging 0.98
R6468:Olfr1061 UTSW 2 86414037 missense probably damaging 0.99
X0023:Olfr1061 UTSW 2 86413959 missense probably benign 0.29
Posted On2014-01-21