Incidental Mutation 'IGL01714:Vmn1r77'
| ID |
104885 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r77
|
| Ensembl Gene |
ENSMUSG00000095864 |
| Gene Name |
vomeronasal 1 receptor 77 |
| Synonyms |
Gm6935 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.054)
|
| Stock # |
IGL01714
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11775226-11776146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 11775277 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 18
(I18F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164446]
[ENSMUST00000226525]
[ENSMUST00000227320]
[ENSMUST00000228213]
|
| AlphaFold |
E9PY60 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164446
AA Change: I18F
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000130869
Gene: ENSMUSG00000095864
AA Change: I18F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
1 |
300 |
1.9e-12 |
PFAM |
|
Pfam:V1R
|
35 |
299 |
5.3e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226525
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227320
AA Change: I18F
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228213
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
T |
C |
8: 73,209,413 (GRCm39) |
|
probably null |
Het |
| Acvrl1 |
T |
A |
15: 101,035,251 (GRCm39) |
I259N |
probably damaging |
Het |
| Ahctf1 |
A |
G |
1: 179,623,442 (GRCm39) |
S59P |
probably damaging |
Het |
| Bcas1 |
T |
C |
2: 170,226,102 (GRCm39) |
|
probably benign |
Het |
| Ccdc33 |
T |
C |
9: 57,937,153 (GRCm39) |
N682S |
possibly damaging |
Het |
| Celf1 |
T |
C |
2: 90,839,552 (GRCm39) |
S326P |
possibly damaging |
Het |
| Cntn1 |
T |
A |
15: 92,151,870 (GRCm39) |
C436* |
probably null |
Het |
| Cyp2d40 |
T |
G |
15: 82,645,441 (GRCm39) |
D142A |
possibly damaging |
Het |
| Dennd2b |
A |
G |
7: 109,169,269 (GRCm39) |
S9P |
probably damaging |
Het |
| Dnhd1 |
C |
T |
7: 105,370,149 (GRCm39) |
L4525F |
probably damaging |
Het |
| Drosha |
A |
G |
15: 12,878,870 (GRCm39) |
Y732C |
probably damaging |
Het |
| Edn1 |
A |
G |
13: 42,458,490 (GRCm39) |
N101S |
probably benign |
Het |
| Faxc |
C |
T |
4: 21,936,688 (GRCm39) |
P108S |
probably damaging |
Het |
| Glb1l2 |
C |
T |
9: 26,679,714 (GRCm39) |
|
probably null |
Het |
| Gm4952 |
G |
T |
19: 12,602,075 (GRCm39) |
R161L |
probably benign |
Het |
| Hipk2 |
A |
T |
6: 38,796,117 (GRCm39) |
Y51N |
probably damaging |
Het |
| Id4 |
T |
G |
13: 48,415,266 (GRCm39) |
I98S |
probably damaging |
Het |
| Klf6 |
T |
C |
13: 5,916,658 (GRCm39) |
S268P |
probably benign |
Het |
| Kmt2c |
G |
T |
5: 25,518,398 (GRCm39) |
T2427N |
probably benign |
Het |
| Lrp3 |
T |
G |
7: 34,905,496 (GRCm39) |
|
probably null |
Het |
| Lrrc66 |
A |
G |
5: 73,787,320 (GRCm39) |
I10T |
probably benign |
Het |
| Mapkap1 |
T |
G |
2: 34,408,855 (GRCm39) |
V281G |
probably damaging |
Het |
| Ncor1 |
T |
A |
11: 62,225,410 (GRCm39) |
I1054F |
possibly damaging |
Het |
| Or8k25 |
T |
C |
2: 86,244,144 (GRCm39) |
N84S |
probably benign |
Het |
| Ppp1r9b |
C |
A |
11: 94,896,180 (GRCm39) |
T817N |
probably damaging |
Het |
| Prkd2 |
T |
A |
7: 16,597,867 (GRCm39) |
I659N |
probably damaging |
Het |
| Radil |
T |
C |
5: 142,529,152 (GRCm39) |
|
probably benign |
Het |
| S2bpcox16 |
A |
G |
12: 81,557,664 (GRCm39) |
I47T |
probably damaging |
Het |
| Smarcd1 |
C |
T |
15: 99,610,302 (GRCm39) |
T474I |
probably damaging |
Het |
| Srd5a1 |
C |
T |
13: 69,759,181 (GRCm39) |
W62* |
probably null |
Het |
| St6galnac2 |
C |
T |
11: 116,575,945 (GRCm39) |
D169N |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,687,523 (GRCm39) |
|
probably benign |
Het |
| Xrcc5 |
A |
T |
1: 72,369,143 (GRCm39) |
K332N |
probably damaging |
Het |
|
| Other mutations in Vmn1r77 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn1r77
|
APN |
7 |
11,775,403 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01304:Vmn1r77
|
APN |
7 |
11,775,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01360:Vmn1r77
|
APN |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01829:Vmn1r77
|
APN |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02336:Vmn1r77
|
APN |
7 |
11,775,223 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0456:Vmn1r77
|
UTSW |
7 |
11,775,665 (GRCm39) |
nonsense |
probably null |
|
|
R0622:Vmn1r77
|
UTSW |
7 |
11,775,315 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1244:Vmn1r77
|
UTSW |
7 |
11,775,847 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R1696:Vmn1r77
|
UTSW |
7 |
11,775,547 (GRCm39) |
nonsense |
probably null |
|
|
R1836:Vmn1r77
|
UTSW |
7 |
11,775,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1898:Vmn1r77
|
UTSW |
7 |
11,775,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4533:Vmn1r77
|
UTSW |
7 |
11,775,756 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4668:Vmn1r77
|
UTSW |
7 |
11,775,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5381:Vmn1r77
|
UTSW |
7 |
11,775,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Vmn1r77
|
UTSW |
7 |
11,775,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Vmn1r77
|
UTSW |
7 |
11,775,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7032:Vmn1r77
|
UTSW |
7 |
11,776,017 (GRCm39) |
nonsense |
probably null |
|
|
R7044:Vmn1r77
|
UTSW |
7 |
11,775,761 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7302:Vmn1r77
|
UTSW |
7 |
11,775,983 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7417:Vmn1r77
|
UTSW |
7 |
11,775,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7436:Vmn1r77
|
UTSW |
7 |
11,775,694 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8487:Vmn1r77
|
UTSW |
7 |
11,775,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8862:Vmn1r77
|
UTSW |
7 |
11,776,060 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9614:Vmn1r77
|
UTSW |
7 |
11,775,766 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9753:Vmn1r77
|
UTSW |
7 |
11,775,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1176:Vmn1r77
|
UTSW |
7 |
11,775,508 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,695 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,674 (GRCm39) |
missense |
|
|
|
Z1177:Vmn1r77
|
UTSW |
7 |
11,775,524 (GRCm39) |
missense |
probably benign |
0.36 |
|
| Posted On |
2014-01-21 |
Incidental Mutation