Incidental Mutation 'IGL01714:Lrrc66'
ID 104898
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc66
Ensembl Gene ENSMUSG00000067206
Gene Name leucine rich repeat containing 66
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01714
Quality Score
Status
Chromosome 5
Chromosomal Location 73763985-73789771 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73787320 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 10 (I10T)
Ref Sequence ENSEMBL: ENSMUSP00000120280 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081170] [ENSMUST00000087177] [ENSMUST00000152215]
AlphaFold Q8K0B3
Predicted Effect probably benign
Transcript: ENSMUST00000081170
SMART Domains Protein: ENSMUSP00000079937
Gene: ENSMUSG00000029156

DomainStartEndE-ValueType
Pfam:Sarcoglycan_1 56 305 4.3e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000087177
AA Change: I10T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000084423
Gene: ENSMUSG00000067206
AA Change: I10T

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRR 140 162 1.81e1 SMART
LRR_TYP 163 186 9.44e-2 SMART
LRR 187 210 1.26e2 SMART
LRR 211 234 4.84e1 SMART
low complexity region 298 309 N/A INTRINSIC
transmembrane domain 369 391 N/A INTRINSIC
low complexity region 434 445 N/A INTRINSIC
low complexity region 842 859 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000152215
AA Change: I10T

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000120280
Gene: ENSMUSG00000067206
AA Change: I10T

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(1) Gene trapped(1)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik T C 8: 73,209,413 (GRCm39) probably null Het
Acvrl1 T A 15: 101,035,251 (GRCm39) I259N probably damaging Het
Ahctf1 A G 1: 179,623,442 (GRCm39) S59P probably damaging Het
Bcas1 T C 2: 170,226,102 (GRCm39) probably benign Het
Ccdc33 T C 9: 57,937,153 (GRCm39) N682S possibly damaging Het
Celf1 T C 2: 90,839,552 (GRCm39) S326P possibly damaging Het
Cntn1 T A 15: 92,151,870 (GRCm39) C436* probably null Het
Cyp2d40 T G 15: 82,645,441 (GRCm39) D142A possibly damaging Het
Dennd2b A G 7: 109,169,269 (GRCm39) S9P probably damaging Het
Dnhd1 C T 7: 105,370,149 (GRCm39) L4525F probably damaging Het
Drosha A G 15: 12,878,870 (GRCm39) Y732C probably damaging Het
Edn1 A G 13: 42,458,490 (GRCm39) N101S probably benign Het
Faxc C T 4: 21,936,688 (GRCm39) P108S probably damaging Het
Glb1l2 C T 9: 26,679,714 (GRCm39) probably null Het
Gm4952 G T 19: 12,602,075 (GRCm39) R161L probably benign Het
Hipk2 A T 6: 38,796,117 (GRCm39) Y51N probably damaging Het
Id4 T G 13: 48,415,266 (GRCm39) I98S probably damaging Het
Klf6 T C 13: 5,916,658 (GRCm39) S268P probably benign Het
Kmt2c G T 5: 25,518,398 (GRCm39) T2427N probably benign Het
Lrp3 T G 7: 34,905,496 (GRCm39) probably null Het
Mapkap1 T G 2: 34,408,855 (GRCm39) V281G probably damaging Het
Ncor1 T A 11: 62,225,410 (GRCm39) I1054F possibly damaging Het
Or8k25 T C 2: 86,244,144 (GRCm39) N84S probably benign Het
Ppp1r9b C A 11: 94,896,180 (GRCm39) T817N probably damaging Het
Prkd2 T A 7: 16,597,867 (GRCm39) I659N probably damaging Het
Radil T C 5: 142,529,152 (GRCm39) probably benign Het
S2bpcox16 A G 12: 81,557,664 (GRCm39) I47T probably damaging Het
Smarcd1 C T 15: 99,610,302 (GRCm39) T474I probably damaging Het
Srd5a1 C T 13: 69,759,181 (GRCm39) W62* probably null Het
St6galnac2 C T 11: 116,575,945 (GRCm39) D169N probably damaging Het
Ttn T A 2: 76,687,523 (GRCm39) probably benign Het
Vmn1r77 A T 7: 11,775,277 (GRCm39) I18F probably benign Het
Xrcc5 A T 1: 72,369,143 (GRCm39) K332N probably damaging Het
Other mutations in Lrrc66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Lrrc66 APN 5 73,764,457 (GRCm39) missense probably benign 0.10
IGL00913:Lrrc66 APN 5 73,765,499 (GRCm39) missense possibly damaging 0.76
IGL00954:Lrrc66 APN 5 73,765,741 (GRCm39) missense possibly damaging 0.94
IGL01061:Lrrc66 APN 5 73,772,842 (GRCm39) missense probably benign 0.01
IGL01343:Lrrc66 APN 5 73,765,806 (GRCm39) missense probably damaging 0.98
IGL01822:Lrrc66 APN 5 73,787,311 (GRCm39) missense probably benign 0.17
IGL02005:Lrrc66 APN 5 73,766,077 (GRCm39) missense possibly damaging 0.83
IGL02166:Lrrc66 APN 5 73,764,634 (GRCm39) missense probably damaging 0.99
IGL02380:Lrrc66 APN 5 73,787,009 (GRCm39) missense possibly damaging 0.55
IGL03162:Lrrc66 APN 5 73,764,725 (GRCm39) missense probably benign
BB002:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
BB012:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
D4043:Lrrc66 UTSW 5 73,764,869 (GRCm39) missense probably benign 0.03
R0126:Lrrc66 UTSW 5 73,764,431 (GRCm39) missense probably benign 0.10
R0437:Lrrc66 UTSW 5 73,765,030 (GRCm39) missense probably benign 0.23
R0638:Lrrc66 UTSW 5 73,772,816 (GRCm39) splice site probably benign
R0658:Lrrc66 UTSW 5 73,768,287 (GRCm39) missense probably benign 0.40
R0729:Lrrc66 UTSW 5 73,765,757 (GRCm39) missense probably benign
R1603:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1774:Lrrc66 UTSW 5 73,768,198 (GRCm39) missense probably benign 0.16
R1831:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1832:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1902:Lrrc66 UTSW 5 73,764,965 (GRCm39) missense probably damaging 0.99
R2858:Lrrc66 UTSW 5 73,764,646 (GRCm39) missense probably benign 0.08
R4097:Lrrc66 UTSW 5 73,765,047 (GRCm39) missense possibly damaging 0.94
R4164:Lrrc66 UTSW 5 73,787,119 (GRCm39) splice site probably null
R4582:Lrrc66 UTSW 5 73,765,580 (GRCm39) missense possibly damaging 0.94
R4708:Lrrc66 UTSW 5 73,787,005 (GRCm39) missense probably benign 0.06
R4856:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R4886:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R5074:Lrrc66 UTSW 5 73,765,354 (GRCm39) missense probably damaging 1.00
R5464:Lrrc66 UTSW 5 73,765,622 (GRCm39) missense probably benign 0.05
R5640:Lrrc66 UTSW 5 73,765,977 (GRCm39) missense probably benign 0.00
R5709:Lrrc66 UTSW 5 73,766,206 (GRCm39) missense probably benign
R5811:Lrrc66 UTSW 5 73,772,860 (GRCm39) missense possibly damaging 0.82
R6146:Lrrc66 UTSW 5 73,765,432 (GRCm39) missense probably benign 0.10
R7037:Lrrc66 UTSW 5 73,764,504 (GRCm39) missense probably benign 0.10
R7041:Lrrc66 UTSW 5 73,765,899 (GRCm39) missense possibly damaging 0.81
R7141:Lrrc66 UTSW 5 73,787,320 (GRCm39) missense probably benign 0.10
R7201:Lrrc66 UTSW 5 73,787,240 (GRCm39) missense probably benign 0.11
R7250:Lrrc66 UTSW 5 73,768,224 (GRCm39) missense probably benign 0.03
R7367:Lrrc66 UTSW 5 73,765,724 (GRCm39) missense probably benign 0.13
R7773:Lrrc66 UTSW 5 73,764,664 (GRCm39) missense probably damaging 0.98
R7925:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
R8057:Lrrc66 UTSW 5 73,764,875 (GRCm39) nonsense probably null
R8167:Lrrc66 UTSW 5 73,786,952 (GRCm39) nonsense probably null
R8552:Lrrc66 UTSW 5 73,768,228 (GRCm39) missense probably benign 0.16
R8834:Lrrc66 UTSW 5 73,765,928 (GRCm39) missense possibly damaging 0.56
R8992:Lrrc66 UTSW 5 73,787,227 (GRCm39) missense probably benign 0.04
R9017:Lrrc66 UTSW 5 73,765,244 (GRCm39) missense possibly damaging 0.94
R9051:Lrrc66 UTSW 5 73,765,268 (GRCm39) missense probably benign 0.00
R9051:Lrrc66 UTSW 5 73,765,267 (GRCm39) missense probably benign 0.05
Posted On 2014-01-21