Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01716:Ncoa7'

104944

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ncoa7

Ensembl Gene

ENSMUSG00000039697

Gene Name

nuclear receptor coactivator 7

Synonyms

9030406N13Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01716

Quality Score

Status

Chromosome

Chromosomal Location

30521578-30683401 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 30538330 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 685 (I685T)

Ref Sequence

ENSEMBL: ENSMUSP00000150021 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000068567] [ENSMUST00000213836] [ENSMUST00000215740] [ENSMUST00000215926]

AlphaFold

Q6DFV7

Predicted Effect

probably benign
Transcript: ENSMUST00000068567
AA Change: I734T

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000066741
Gene: ENSMUSG00000039697
AA Change: I734T

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
LysM	118	161	2.24e-7	SMART
low complexity region	165	176	N/A	INTRINSIC
TLDc	781	943	2.86e-64	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000213836
AA Change: I723T

PolyPhen 2 Score 0.102 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably benign
Transcript: ENSMUST00000215740
AA Change: I734T

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably damaging
Transcript: ENSMUST00000215926
AA Change: I685T

PolyPhen 2 Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(108) : Gene trapped(108)

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alms1	G	A	6: 85,605,076 (GRCm39)	R1773Q	probably benign	Het
Apba2	T	C	7: 64,395,574 (GRCm39)		probably benign	Het
Asap2	A	G	12: 21,304,307 (GRCm39)	D741G	possibly damaging	Het
Cfap65	T	C	1: 74,966,353 (GRCm39)	T325A	probably benign	Het
Cyp2b23	A	T	7: 26,378,915 (GRCm39)	V183E	probably damaging	Het
Cyp4f14	T	A	17: 33,124,470 (GRCm39)		probably benign	Het
Dip2b	A	G	15: 100,107,517 (GRCm39)	T1176A	probably benign	Het
Dnah1	A	G	14: 30,985,335 (GRCm39)	I3852T	probably benign	Het
Exoc6	T	A	19: 37,671,412 (GRCm39)	S801T	probably damaging	Het
Fancd2os	T	C	6: 113,574,615 (GRCm39)	I130M	probably damaging	Het
Flywch1	A	G	17: 23,982,000 (GRCm39)	V68A	probably benign	Het
Kif24	T	C	4: 41,393,454 (GRCm39)	T1140A	probably benign	Het
Limk2	C	T	11: 3,308,990 (GRCm39)		probably null	Het
Mag	C	T	7: 30,599,812 (GRCm39)	V576I	probably benign	Het
Mei4	C	T	9: 81,772,235 (GRCm39)	A16V	probably damaging	Het
Nfxl1	A	T	5: 72,698,277 (GRCm39)	V256E	probably damaging	Het
Or1a1	C	T	11: 74,087,207 (GRCm39)	R293W	probably benign	Het
Or1j20	T	A	2: 36,759,679 (GRCm39)	F34I	probably benign	Het
Or9g4b	A	T	2: 85,616,487 (GRCm39)	I211F	probably damaging	Het
Pcdhb2	T	C	18: 37,429,791 (GRCm39)	V588A	probably damaging	Het
Pcdhb5	T	G	18: 37,454,075 (GRCm39)	S152A	probably benign	Het
Pcdhb9	T	A	18: 37,536,228 (GRCm39)	S741T	probably damaging	Het
Plekha4	C	A	7: 45,183,767 (GRCm39)	S66R	probably damaging	Het
Prex2	A	G	1: 11,336,278 (GRCm39)	N1492S	probably benign	Het
Rbfox3	T	C	11: 118,404,115 (GRCm39)	H28R	possibly damaging	Het
Reep2	C	T	18: 34,979,302 (GRCm39)	T209I	probably benign	Het
Rptn	A	G	3: 93,304,017 (GRCm39)	H450R	possibly damaging	Het
Spock3	A	G	8: 63,808,384 (GRCm39)	D427G	unknown	Het
Tnfrsf1b	C	T	4: 144,942,493 (GRCm39)	C430Y	probably damaging	Het
Ttn	T	A	2: 76,560,746 (GRCm39)	L29218F	probably damaging	Het
Ttn	A	T	2: 76,560,748 (GRCm39)	L29218I	probably damaging	Het
Tubgcp3	T	C	8: 12,691,094 (GRCm39)		probably benign	Het
Upp2	A	C	2: 58,680,058 (GRCm39)	T295P	probably damaging	Het
Xpo7	A	G	14: 70,922,995 (GRCm39)	V528A	probably damaging	Het
Zc3h7a	A	G	16: 10,963,580 (GRCm39)	C714R	probably damaging	Het
Zfp764l1	A	G	7: 126,991,208 (GRCm39)	S260P	possibly damaging	Het
Zpbp	A	T	11: 11,354,052 (GRCm39)	S295T	probably benign	Het

Other mutations in Ncoa7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01406:Ncoa7	APN	10	30,566,836 (GRCm39)	missense	probably damaging	1.00
IGL02114:Ncoa7	APN	10	30,538,360 (GRCm39)	missense	probably damaging	1.00
IGL02170:Ncoa7	APN	10	30,565,849 (GRCm39)	missense	possibly damaging	0.94
IGL02436:Ncoa7	APN	10	30,570,143 (GRCm39)	missense	probably damaging	1.00
IGL02499:Ncoa7	APN	10	30,566,885 (GRCm39)	missense	probably benign	0.04
IGL02533:Ncoa7	APN	10	30,598,781 (GRCm39)	missense	probably damaging	1.00
IGL02533:Ncoa7	APN	10	30,566,895 (GRCm39)	missense	possibly damaging	0.87
IGL02590:Ncoa7	APN	10	30,570,159 (GRCm39)	missense	probably damaging	1.00
IGL02657:Ncoa7	APN	10	30,528,972 (GRCm39)	missense	probably damaging	1.00
IGL03065:Ncoa7	APN	10	30,523,993 (GRCm39)	missense	probably damaging	1.00
IGL03088:Ncoa7	APN	10	30,574,121 (GRCm39)	splice site	probably null
IGL03090:Ncoa7	APN	10	30,538,396 (GRCm39)	missense	probably damaging	0.96
IGL03196:Ncoa7	APN	10	30,523,510 (GRCm39)	utr 3 prime	probably benign
D6062:Ncoa7	UTSW	10	30,598,651 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0058:Ncoa7	UTSW	10	30,523,537 (GRCm39)	missense	probably damaging	1.00
R0578:Ncoa7	UTSW	10	30,577,913 (GRCm39)	critical splice donor site	probably null
R0729:Ncoa7	UTSW	10	30,567,575 (GRCm39)	missense	probably benign	0.00
R1538:Ncoa7	UTSW	10	30,570,207 (GRCm39)	missense	probably damaging	0.99
R1539:Ncoa7	UTSW	10	30,647,725 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1574:Ncoa7	UTSW	10	30,570,097 (GRCm39)	missense	probably damaging	1.00
R1624:Ncoa7	UTSW	10	30,580,655 (GRCm39)	missense	possibly damaging	0.87
R1639:Ncoa7	UTSW	10	30,577,988 (GRCm39)	missense	probably damaging	1.00
R1655:Ncoa7	UTSW	10	30,574,241 (GRCm39)	critical splice acceptor site	probably null
R1876:Ncoa7	UTSW	10	30,574,122 (GRCm39)	intron	probably benign
R1885:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1886:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1887:Ncoa7	UTSW	10	30,524,448 (GRCm39)	missense	possibly damaging	0.81
R1909:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R1938:Ncoa7	UTSW	10	30,574,166 (GRCm39)	missense	probably benign	0.02
R1965:Ncoa7	UTSW	10	30,530,426 (GRCm39)	nonsense	probably null
R1978:Ncoa7	UTSW	10	30,567,295 (GRCm39)	missense	probably benign
R2303:Ncoa7	UTSW	10	30,530,431 (GRCm39)	missense	probably damaging	1.00
R3777:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R3778:Ncoa7	UTSW	10	30,565,752 (GRCm39)	missense	probably damaging	1.00
R4026:Ncoa7	UTSW	10	30,598,720 (GRCm39)	missense	probably benign	0.02
R4230:Ncoa7	UTSW	10	30,574,253 (GRCm39)	splice site	probably null
R4667:Ncoa7	UTSW	10	30,566,786 (GRCm39)	missense	probably damaging	1.00
R4786:Ncoa7	UTSW	10	30,531,638 (GRCm39)	missense	probably benign	0.28
R4809:Ncoa7	UTSW	10	30,647,758 (GRCm39)	missense	possibly damaging	0.92
R4820:Ncoa7	UTSW	10	30,524,472 (GRCm39)	missense	probably damaging	1.00
R4839:Ncoa7	UTSW	10	30,598,655 (GRCm39)	missense	possibly damaging	0.93
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R4861:Ncoa7	UTSW	10	30,580,608 (GRCm39)	missense	probably benign
R5271:Ncoa7	UTSW	10	30,598,725 (GRCm39)	missense	probably benign	0.02
R5384:Ncoa7	UTSW	10	30,598,813 (GRCm39)	missense	probably benign	0.00
R5418:Ncoa7	UTSW	10	30,524,035 (GRCm39)	missense	probably damaging	1.00
R5964:Ncoa7	UTSW	10	30,580,632 (GRCm39)	missense	probably damaging	1.00
R6257:Ncoa7	UTSW	10	30,570,173 (GRCm39)	missense	probably damaging	1.00
R6683:Ncoa7	UTSW	10	30,647,717 (GRCm39)	missense	probably damaging	0.99
R6813:Ncoa7	UTSW	10	30,572,188 (GRCm39)	missense	probably damaging	1.00
R6910:Ncoa7	UTSW	10	30,570,117 (GRCm39)	missense	possibly damaging	0.89
R7123:Ncoa7	UTSW	10	30,530,435 (GRCm39)	missense	probably benign	0.28
R7327:Ncoa7	UTSW	10	30,565,796 (GRCm39)	missense	probably damaging	1.00
R7412:Ncoa7	UTSW	10	30,598,847 (GRCm39)	missense	possibly damaging	0.94
R7638:Ncoa7	UTSW	10	30,598,794 (GRCm39)	missense	probably benign	0.35
R7653:Ncoa7	UTSW	10	30,570,239 (GRCm39)	missense	probably damaging	1.00
R7848:Ncoa7	UTSW	10	30,524,414 (GRCm39)	missense	possibly damaging	0.82
R7861:Ncoa7	UTSW	10	30,567,056 (GRCm39)	missense	probably benign	0.38
R8125:Ncoa7	UTSW	10	30,570,087 (GRCm39)	missense	possibly damaging	0.80
R8198:Ncoa7	UTSW	10	30,580,664 (GRCm39)	missense	probably benign	0.00
R8240:Ncoa7	UTSW	10	30,567,725 (GRCm39)	missense	probably benign	0.45
R8353:Ncoa7	UTSW	10	30,570,155 (GRCm39)	missense	probably damaging	1.00
R8509:Ncoa7	UTSW	10	30,572,048 (GRCm39)	missense	probably benign	0.00
R8861:Ncoa7	UTSW	10	30,567,364 (GRCm39)	missense	probably benign	0.02
R9040:Ncoa7	UTSW	10	30,530,389 (GRCm39)	missense	probably benign	0.00
R9136:Ncoa7	UTSW	10	30,567,628 (GRCm39)	missense	probably benign	0.00

Posted On

2014-01-21