Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01718:Gpr155'

105003

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr155

Ensembl Gene

ENSMUSG00000041762

Gene Name

G protein-coupled receptor 155

Synonyms

DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01718

Quality Score

Status

Chromosome

Chromosomal Location

73171850-73216842 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 73212576 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 16 (M16V)

Ref Sequence

ENSEMBL: ENSMUSP00000107675 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112044]

AlphaFold

A2AWR3

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000048504

SMART Domains

Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	1.9e-16	PFAM
Pfam:Mem_trans	187	360	4.9e-12	PFAM
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000076463
AA Change: M16V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762
AA Change: M16V

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
transmembrane domain	209	231	N/A	INTRINSIC
transmembrane domain	241	260	N/A	INTRINSIC
transmembrane domain	272	291	N/A	INTRINSIC
transmembrane domain	311	330	N/A	INTRINSIC
transmembrane domain	343	365	N/A	INTRINSIC
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC
transmembrane domain	689	711	N/A	INTRINSIC
DEP	759	833	8.28e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112043
AA Change: M16V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762
AA Change: M16V

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
transmembrane domain	209	231	N/A	INTRINSIC
transmembrane domain	241	260	N/A	INTRINSIC
transmembrane domain	272	291	N/A	INTRINSIC
transmembrane domain	311	330	N/A	INTRINSIC
transmembrane domain	343	365	N/A	INTRINSIC
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC
transmembrane domain	689	711	N/A	INTRINSIC
DEP	759	833	8.28e-12	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112044
AA Change: M16V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762
AA Change: M16V

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
Pfam:Mem_trans	187	360	8.3e-11	PFAM
transmembrane domain	382	404	N/A	INTRINSIC
transmembrane domain	414	436	N/A	INTRINSIC
transmembrane domain	449	471	N/A	INTRINSIC
transmembrane domain	491	510	N/A	INTRINSIC
transmembrane domain	629	651	N/A	INTRINSIC
transmembrane domain	661	683	N/A	INTRINSIC
DEP	731	805	8.28e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134595

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138573

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000144735

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184503

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a3	A	G	7: 66,049,953 (GRCm39)	F422L	possibly damaging	Het
Ap2m1	T	C	16: 20,360,944 (GRCm39)		probably benign	Het
Asic1	A	G	15: 99,569,883 (GRCm39)	Y68C	probably damaging	Het
Ccdc18	A	G	5: 108,349,214 (GRCm39)	D1002G	possibly damaging	Het
Cyp2c29	A	T	19: 39,318,704 (GRCm39)	I434F	possibly damaging	Het
Diaph3	T	A	14: 86,893,774 (GRCm39)	R78S	unknown	Het
Dnase1l2	T	C	17: 24,660,690 (GRCm39)	D188G	possibly damaging	Het
Exosc9	T	C	3: 36,608,078 (GRCm39)		probably benign	Het
Fgf23	G	A	6: 127,057,436 (GRCm39)	V251I	probably benign	Het
Fndc3c1	T	C	X: 105,489,534 (GRCm39)	T296A	probably benign	Het
Gm5592	A	G	7: 40,938,617 (GRCm39)	E633G	probably damaging	Het
Jakmip3	T	G	7: 138,591,121 (GRCm39)	S2A	possibly damaging	Het
Lrba	T	A	3: 86,258,555 (GRCm39)	N1347K	probably damaging	Het
Mars1	T	C	10: 127,141,707 (GRCm39)	R266G	possibly damaging	Het
Mplkipl1	A	G	19: 61,164,199 (GRCm39)	S79P	probably damaging	Het
Mrgpra1	A	T	7: 46,985,675 (GRCm39)		probably null	Het
Or7g20	T	A	9: 18,946,584 (GRCm39)	L55*	probably null	Het
Pdzk1ip1	T	A	4: 114,950,111 (GRCm39)		probably benign	Het
Ppid	G	T	3: 79,500,986 (GRCm39)	C52F	probably damaging	Het
Reln	A	G	5: 22,152,512 (GRCm39)	I2318T	possibly damaging	Het
Rhpn2	G	A	7: 35,070,179 (GRCm39)	D146N	probably benign	Het
Tspoap1	G	T	11: 87,671,081 (GRCm39)	R1670L	possibly damaging	Het
Ttc22	G	A	4: 106,495,773 (GRCm39)	V376M	probably damaging	Het
Ttn	T	A	2: 76,560,746 (GRCm39)	L29218F	probably damaging	Het
Ttn	A	T	2: 76,560,748 (GRCm39)	L29218I	probably damaging	Het
Zfp609	G	A	9: 65,609,682 (GRCm39)	Q1094*	probably null	Het
Zfp831	C	T	2: 174,485,631 (GRCm39)	T102I	possibly damaging	Het
Zglp1	C	T	9: 20,974,675 (GRCm39)	C171Y	probably benign	Het

Other mutations in Gpr155

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00731:Gpr155	APN	2	73,192,957 (GRCm39)	missense	probably damaging	1.00
IGL01432:Gpr155	APN	2	73,182,229 (GRCm39)	missense	possibly damaging	0.51
IGL01528:Gpr155	APN	2	73,192,767 (GRCm39)	critical splice donor site	probably null
IGL01733:Gpr155	APN	2	73,183,956 (GRCm39)	splice site	probably null
IGL03342:Gpr155	APN	2	73,180,022 (GRCm39)	missense	probably damaging	1.00
PIT1430001:Gpr155	UTSW	2	73,200,482 (GRCm39)	missense	probably benign	0.08
PIT4810001:Gpr155	UTSW	2	73,178,607 (GRCm39)	missense	probably benign	0.08
R0226:Gpr155	UTSW	2	73,197,936 (GRCm39)	missense	probably benign	0.02
R0399:Gpr155	UTSW	2	73,200,346 (GRCm39)	missense	possibly damaging	0.91
R0445:Gpr155	UTSW	2	73,200,488 (GRCm39)	splice site	probably benign
R1570:Gpr155	UTSW	2	73,200,382 (GRCm39)	missense	possibly damaging	0.87
R1598:Gpr155	UTSW	2	73,200,434 (GRCm39)	missense	probably damaging	0.98
R1647:Gpr155	UTSW	2	73,194,508 (GRCm39)	splice site	probably null
R1648:Gpr155	UTSW	2	73,194,508 (GRCm39)	splice site	probably null
R1756:Gpr155	UTSW	2	73,197,921 (GRCm39)	missense	probably benign	0.00
R1760:Gpr155	UTSW	2	73,212,279 (GRCm39)	missense	probably damaging	1.00
R2033:Gpr155	UTSW	2	73,178,526 (GRCm39)	missense	probably benign	0.18
R2044:Gpr155	UTSW	2	73,203,977 (GRCm39)	missense	probably damaging	1.00
R2145:Gpr155	UTSW	2	73,187,002 (GRCm39)	missense	probably benign	0.01
R2172:Gpr155	UTSW	2	73,212,471 (GRCm39)	missense	probably benign	0.00
R2274:Gpr155	UTSW	2	73,178,479 (GRCm39)	critical splice donor site	probably null
R3878:Gpr155	UTSW	2	73,198,736 (GRCm39)	nonsense	probably null
R3924:Gpr155	UTSW	2	73,200,420 (GRCm39)	missense	probably damaging	1.00
R4910:Gpr155	UTSW	2	73,197,882 (GRCm39)	nonsense	probably null
R4950:Gpr155	UTSW	2	73,212,529 (GRCm39)	missense	probably benign
R5337:Gpr155	UTSW	2	73,178,592 (GRCm39)	missense	probably benign	0.32
R5830:Gpr155	UTSW	2	73,200,433 (GRCm39)	missense	possibly damaging	0.93
R5887:Gpr155	UTSW	2	73,174,062 (GRCm39)	nonsense	probably null
R5929:Gpr155	UTSW	2	73,204,011 (GRCm39)	nonsense	probably null
R6293:Gpr155	UTSW	2	73,204,341 (GRCm39)	missense	possibly damaging	0.47
R6553:Gpr155	UTSW	2	73,179,989 (GRCm39)	missense	probably damaging	1.00
R6585:Gpr155	UTSW	2	73,179,989 (GRCm39)	missense	probably damaging	1.00
R7003:Gpr155	UTSW	2	73,173,961 (GRCm39)	missense	probably damaging	0.99
R7353:Gpr155	UTSW	2	73,197,835 (GRCm39)	nonsense	probably null
R7506:Gpr155	UTSW	2	73,198,683 (GRCm39)	missense	probably damaging	0.97
R7631:Gpr155	UTSW	2	73,213,291 (GRCm39)	intron	probably benign
R7753:Gpr155	UTSW	2	73,212,550 (GRCm39)	missense	probably benign	0.27
R7810:Gpr155	UTSW	2	73,212,296 (GRCm39)	missense	probably damaging	0.99
R7813:Gpr155	UTSW	2	73,212,329 (GRCm39)	nonsense	probably null
R7815:Gpr155	UTSW	2	73,192,904 (GRCm39)	missense	probably benign
R7873:Gpr155	UTSW	2	73,173,934 (GRCm39)	missense	possibly damaging	0.51
R8506:Gpr155	UTSW	2	73,173,806 (GRCm39)	missense	probably damaging	0.99
R8680:Gpr155	UTSW	2	73,174,039 (GRCm39)	missense	probably damaging	0.99
R8856:Gpr155	UTSW	2	73,203,993 (GRCm39)	missense	probably benign	0.27
R8872:Gpr155	UTSW	2	73,197,936 (GRCm39)	missense	probably benign	0.02
R9116:Gpr155	UTSW	2	73,204,109 (GRCm39)	missense	possibly damaging	0.78
R9683:Gpr155	UTSW	2	73,192,780 (GRCm39)	missense	probably benign

Posted On

2014-01-21