Incidental Mutation 'IGL01728:Agbl3'
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ID105362
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Agbl3
Ensembl Gene ENSMUSG00000038836
Gene NameATP/GTP binding protein-like 3
Synonyms4930431N21Rik, 2900053G10Rik, 6530406M24Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01728
Quality Score
Status
Chromosome6
Chromosomal Location34780432-34859459 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to C at 34782157 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000116066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115009] [ENSMUST00000115012] [ENSMUST00000115014] [ENSMUST00000115016] [ENSMUST00000115017] [ENSMUST00000135304] [ENSMUST00000148834]
Predicted Effect probably null
Transcript: ENSMUST00000115009
AA Change: M1T
Predicted Effect probably null
Transcript: ENSMUST00000115012
AA Change: M1T
Predicted Effect probably null
Transcript: ENSMUST00000115014
AA Change: M1T
SMART Domains Protein: ENSMUSP00000110666
Gene: ENSMUSG00000038836
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115016
AA Change: M1T
SMART Domains Protein: ENSMUSP00000110668
Gene: ENSMUSG00000038836
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 314 563 2.7e-19 PFAM
low complexity region 614 629 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000115017
AA Change: M1T
SMART Domains Protein: ENSMUSP00000110669
Gene: ENSMUSG00000038836
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 309 560 1e-33 PFAM
low complexity region 609 624 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119745
Predicted Effect probably null
Transcript: ENSMUST00000135304
AA Change: M1T
SMART Domains Protein: ENSMUSP00000118303
Gene: ENSMUSG00000038836
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143474
Predicted Effect probably null
Transcript: ENSMUST00000148834
AA Change: M1T
SMART Domains Protein: ENSMUSP00000116066
Gene: ENSMUSG00000038836
AA Change: M1T

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155890
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202017
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019A02Rik A G 1: 53,182,509 S54P probably benign Het
Adamtsl1 T C 4: 86,110,837 I71T probably damaging Het
Ankib1 A G 5: 3,701,992 probably benign Het
Brinp3 T G 1: 146,831,551 probably null Het
Chuk T C 19: 44,098,646 N138S possibly damaging Het
Dock7 G A 4: 98,962,331 T1588M probably damaging Het
Ehbp1 G A 11: 22,101,115 T479I probably damaging Het
Gpn2 T C 4: 133,584,502 I15T possibly damaging Het
Haao A G 17: 83,835,229 F149S probably damaging Het
Hist1h3b G A 13: 23,752,729 R117H probably benign Het
Iqsec3 T A 6: 121,412,664 probably benign Het
Lrrc39 G T 3: 116,579,500 probably benign Het
Ltbp2 C A 12: 84,791,009 S1199I probably damaging Het
Mageb3 G T 2: 121,954,460 P254T probably damaging Het
Mapkbp1 C T 2: 120,023,821 P1300S probably damaging Het
Mtfmt T A 9: 65,435,818 L2H probably damaging Het
Myo18a G T 11: 77,777,856 G181W probably damaging Het
Mzf1 T C 7: 13,051,727 probably benign Het
Nfatc2 A T 2: 168,536,242 L280Q probably damaging Het
Nudt15 A G 14: 73,523,296 probably null Het
Olfr633 T C 7: 103,946,752 F62S probably damaging Het
Olfr920 A G 9: 38,756,095 M136V possibly damaging Het
Parp14 A G 16: 35,857,435 V721A probably damaging Het
Pbp2 G T 6: 135,310,075 N91K probably damaging Het
Pde7b C A 10: 20,434,464 probably null Het
Pramel7 C A 2: 87,491,330 E120D possibly damaging Het
Rbbp5 C T 1: 132,498,080 T516M probably benign Het
Slc16a12 A G 19: 34,690,671 V28A possibly damaging Het
Slc6a9 T C 4: 117,864,605 F276S probably damaging Het
Spata9 A T 13: 75,993,074 I147L probably benign Het
Tenm4 A T 7: 96,896,064 Y2429F probably damaging Het
Tmtc1 A G 6: 148,411,066 S212P probably benign Het
Unc5cl A T 17: 48,459,963 I122F probably damaging Het
Unc79 T A 12: 103,165,684 F2350I probably damaging Het
Other mutations in Agbl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Agbl3 APN 6 34846836 missense probably damaging 1.00
IGL00835:Agbl3 APN 6 34799732 missense probably damaging 1.00
IGL00840:Agbl3 APN 6 34799159 missense possibly damaging 0.95
IGL01090:Agbl3 APN 6 34799887 missense probably benign 0.40
IGL01123:Agbl3 APN 6 34846976 nonsense probably null
IGL01707:Agbl3 APN 6 34839454 missense possibly damaging 0.78
IGL02335:Agbl3 APN 6 34799750 missense probably damaging 1.00
IGL02420:Agbl3 APN 6 34785307 missense possibly damaging 0.47
IGL02551:Agbl3 APN 6 34823071 missense possibly damaging 0.88
IGL02974:Agbl3 APN 6 34799822 missense probably damaging 1.00
IGL03167:Agbl3 APN 6 34857659 missense possibly damaging 0.92
IGL03182:Agbl3 APN 6 34803500 missense probably damaging 1.00
R0044:Agbl3 UTSW 6 34799899 missense probably damaging 1.00
R0499:Agbl3 UTSW 6 34839335 missense probably benign
R0639:Agbl3 UTSW 6 34799705 missense probably damaging 1.00
R0850:Agbl3 UTSW 6 34799204 missense probably damaging 1.00
R1004:Agbl3 UTSW 6 34803451 missense probably damaging 0.99
R1080:Agbl3 UTSW 6 34828235 missense probably benign 0.14
R1589:Agbl3 UTSW 6 34857517 missense possibly damaging 0.77
R2361:Agbl3 UTSW 6 34832505 missense possibly damaging 0.87
R2495:Agbl3 UTSW 6 34846764 missense probably damaging 1.00
R3236:Agbl3 UTSW 6 34823087 splice site probably null
R3237:Agbl3 UTSW 6 34823087 splice site probably null
R3420:Agbl3 UTSW 6 34793965 missense probably benign 0.36
R3421:Agbl3 UTSW 6 34793965 missense probably benign 0.36
R3422:Agbl3 UTSW 6 34793965 missense probably benign 0.36
R3810:Agbl3 UTSW 6 34799729 missense probably damaging 1.00
R3811:Agbl3 UTSW 6 34799729 missense probably damaging 1.00
R4059:Agbl3 UTSW 6 34846899 missense probably damaging 1.00
R4499:Agbl3 UTSW 6 34857598 missense probably benign 0.00
R4687:Agbl3 UTSW 6 34798326 missense probably damaging 1.00
R4854:Agbl3 UTSW 6 34785284 missense probably damaging 0.97
R5354:Agbl3 UTSW 6 34814752 missense probably benign 0.03
R5386:Agbl3 UTSW 6 34799196 missense probably damaging 1.00
R5897:Agbl3 UTSW 6 34803573 missense probably benign 0.21
R6018:Agbl3 UTSW 6 34799255 missense probably damaging 1.00
R6148:Agbl3 UTSW 6 34857753 missense possibly damaging 0.87
R6305:Agbl3 UTSW 6 34782210 missense unknown
R6525:Agbl3 UTSW 6 34803594 nonsense probably null
R6546:Agbl3 UTSW 6 34799299 missense probably damaging 1.00
R6743:Agbl3 UTSW 6 34846953 missense probably benign 0.03
R6986:Agbl3 UTSW 6 34839452 missense probably benign 0.42
Posted On2014-01-21