Incidental Mutation 'IGL01732:Or51t4'
| ID |
105525 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or51t4
|
| Ensembl Gene |
ENSMUSG00000045824 |
| Gene Name |
olfactory receptor family 51 subfamily T member 4 |
| Synonyms |
GA_x6K02T2PBJ9-5659738-5660748, MOR14-9, Olfr574 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.175)
|
| Stock # |
IGL01732
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
102597674-102598714 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 102598446 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Asparagine
at position 248
(I248N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147694
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000052997]
[ENSMUST00000211329]
[ENSMUST00000213477]
[ENSMUST00000216420]
|
| AlphaFold |
F8VQ18 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000052997
AA Change: I258N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000095815
Gene: ENSMUSG00000045824
AA Change: I258N
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
31 |
N/A |
INTRINSIC |
|
Pfam:7tm_4
|
44 |
323 |
3.8e-96 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
48 |
195 |
1.2e-8 |
PFAM |
|
Pfam:7tm_1
|
54 |
305 |
2e-17 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000211329
AA Change: I248N
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000213477
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000216420
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 46 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aldh4a1 |
G |
T |
4: 139,369,471 (GRCm39) |
E341* |
probably null |
Het |
| Alpk3 |
A |
G |
7: 80,707,390 (GRCm39) |
R5G |
unknown |
Het |
| Arhgef10l |
C |
T |
4: 140,307,726 (GRCm39) |
V113M |
probably damaging |
Het |
| Brca2 |
T |
A |
5: 150,465,852 (GRCm39) |
I1872K |
probably benign |
Het |
| Cdk17 |
C |
A |
10: 93,053,907 (GRCm39) |
P134T |
probably benign |
Het |
| Cerk |
A |
G |
15: 86,030,517 (GRCm39) |
S35P |
possibly damaging |
Het |
| Cfap126 |
T |
C |
1: 170,954,305 (GRCm39) |
V174A |
possibly damaging |
Het |
| Cfhr1 |
T |
C |
1: 139,478,606 (GRCm39) |
T255A |
probably benign |
Het |
| Clcn1 |
A |
G |
6: 42,287,606 (GRCm39) |
|
probably benign |
Het |
| Copz1 |
A |
G |
15: 103,206,318 (GRCm39) |
E151G |
probably benign |
Het |
| Cubn |
G |
A |
2: 13,494,747 (GRCm39) |
Q101* |
probably null |
Het |
| Eri1 |
T |
C |
8: 35,958,397 (GRCm39) |
E12G |
possibly damaging |
Het |
| Fut9 |
A |
G |
4: 25,619,867 (GRCm39) |
F316L |
possibly damaging |
Het |
| Garin1a |
A |
T |
6: 29,285,979 (GRCm39) |
H146L |
probably damaging |
Het |
| Gm973 |
A |
G |
1: 59,669,396 (GRCm39) |
I816V |
probably benign |
Het |
| Itln1 |
A |
G |
1: 171,362,348 (GRCm39) |
M11T |
probably benign |
Het |
| Klc2 |
C |
T |
19: 5,159,825 (GRCm39) |
R458Q |
probably damaging |
Het |
| Lrrc8b |
A |
T |
5: 105,633,826 (GRCm39) |
E766V |
probably damaging |
Het |
| Mmadhc |
A |
T |
2: 50,171,197 (GRCm39) |
I205N |
probably damaging |
Het |
| Myo10 |
A |
G |
15: 25,732,149 (GRCm39) |
I342V |
probably benign |
Het |
| Ncapg |
T |
A |
5: 45,851,195 (GRCm39) |
V796D |
probably damaging |
Het |
| Olfm3 |
A |
C |
3: 114,890,649 (GRCm39) |
D134A |
possibly damaging |
Het |
| Or3a1c |
T |
C |
11: 74,046,279 (GRCm39) |
C100R |
probably damaging |
Het |
| Or56b2 |
T |
C |
7: 104,337,543 (GRCm39) |
M107T |
possibly damaging |
Het |
| Phldb3 |
A |
G |
7: 24,326,751 (GRCm39) |
E593G |
probably damaging |
Het |
| Plcg1 |
T |
A |
2: 160,589,699 (GRCm39) |
D74E |
probably damaging |
Het |
| Plekhm3 |
T |
C |
1: 64,961,407 (GRCm39) |
D283G |
probably benign |
Het |
| Pnpla6 |
C |
A |
8: 3,572,616 (GRCm39) |
T279N |
probably damaging |
Het |
| Prkcq |
G |
A |
2: 11,265,644 (GRCm39) |
|
probably benign |
Het |
| Rbm11 |
G |
A |
16: 75,397,510 (GRCm39) |
A147T |
probably benign |
Het |
| Rnf103 |
A |
G |
6: 71,487,366 (GRCm39) |
K666E |
probably damaging |
Het |
| Selenos |
A |
G |
7: 65,730,137 (GRCm39) |
Y45C |
probably damaging |
Het |
| Septin11 |
A |
G |
5: 93,309,085 (GRCm39) |
Y255C |
probably damaging |
Het |
| Serpinb3c |
T |
C |
1: 107,199,702 (GRCm39) |
H273R |
probably benign |
Het |
| Slc35f2 |
A |
G |
9: 53,713,909 (GRCm39) |
D141G |
probably damaging |
Het |
| Sntg2 |
A |
T |
12: 30,362,648 (GRCm39) |
Y33N |
probably damaging |
Het |
| Snx19 |
C |
A |
9: 30,373,649 (GRCm39) |
T904K |
probably damaging |
Het |
| Tenm4 |
A |
G |
7: 96,544,716 (GRCm39) |
Y2244C |
probably damaging |
Het |
| Tescl |
A |
G |
7: 24,032,872 (GRCm39) |
V151A |
probably damaging |
Het |
| Tnrc18 |
C |
T |
5: 142,757,816 (GRCm39) |
V902M |
unknown |
Het |
| Trmt13 |
A |
G |
3: 116,375,113 (GRCm39) |
L465S |
probably damaging |
Het |
| Ube2j2 |
T |
G |
4: 156,041,788 (GRCm39) |
V249G |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,391,273 (GRCm39) |
K4737R |
unknown |
Het |
| Zc3h6 |
T |
C |
2: 128,853,795 (GRCm39) |
I430T |
probably damaging |
Het |
| Zfp750 |
G |
A |
11: 121,403,819 (GRCm39) |
S352L |
probably benign |
Het |
| Zfp819 |
A |
G |
7: 43,265,846 (GRCm39) |
K34E |
probably benign |
Het |
|
| Other mutations in Or51t4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01154:Or51t4
|
APN |
7 |
102,598,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02185:Or51t4
|
APN |
7 |
102,597,721 (GRCm39) |
missense |
probably damaging |
0.96 |
|
PIT4382001:Or51t4
|
UTSW |
7 |
102,598,656 (GRCm39) |
missense |
probably benign |
|
|
PIT4520001:Or51t4
|
UTSW |
7 |
102,597,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Or51t4
|
UTSW |
7 |
102,597,939 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1616:Or51t4
|
UTSW |
7 |
102,597,721 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2041:Or51t4
|
UTSW |
7 |
102,598,170 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2079:Or51t4
|
UTSW |
7 |
102,598,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2261:Or51t4
|
UTSW |
7 |
102,598,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2263:Or51t4
|
UTSW |
7 |
102,598,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2513:Or51t4
|
UTSW |
7 |
102,598,700 (GRCm39) |
missense |
probably benign |
|
|
R2903:Or51t4
|
UTSW |
7 |
102,598,661 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4445:Or51t4
|
UTSW |
7 |
102,598,005 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4512:Or51t4
|
UTSW |
7 |
102,597,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4513:Or51t4
|
UTSW |
7 |
102,597,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4528:Or51t4
|
UTSW |
7 |
102,598,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Or51t4
|
UTSW |
7 |
102,598,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5935:Or51t4
|
UTSW |
7 |
102,598,017 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6784:Or51t4
|
UTSW |
7 |
102,597,722 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6889:Or51t4
|
UTSW |
7 |
102,597,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7082:Or51t4
|
UTSW |
7 |
102,598,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7125:Or51t4
|
UTSW |
7 |
102,598,386 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7549:Or51t4
|
UTSW |
7 |
102,597,798 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7564:Or51t4
|
UTSW |
7 |
102,598,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7947:Or51t4
|
UTSW |
7 |
102,598,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Or51t4
|
UTSW |
7 |
102,598,531 (GRCm39) |
nonsense |
probably null |
|
|
R8518:Or51t4
|
UTSW |
7 |
102,597,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8859:Or51t4
|
UTSW |
7 |
102,598,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9116:Or51t4
|
UTSW |
7 |
102,598,527 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9327:Or51t4
|
UTSW |
7 |
102,597,687 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9408:Or51t4
|
UTSW |
7 |
102,598,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Or51t4
|
UTSW |
7 |
102,597,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-01-21 |
Incidental Mutation