Incidental Mutation 'IGL01732:Or56b2'
ID 105528
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or56b2
Ensembl Gene ENSMUSG00000073920
Gene Name olfactory receptor family 56 subfamily B member 2
Synonyms Olfr661, MOR40-4, GA_x6K02T2PBJ9-7316375-7317334
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # IGL01732
Quality Score
Status
Chromosome 7
Chromosomal Location 104337224-104338183 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 104337543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 107 (M107T)
Ref Sequence ENSEMBL: ENSMUSP00000151208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098168] [ENSMUST00000214876]
AlphaFold Q99NH4
Predicted Effect possibly damaging
Transcript: ENSMUST00000098168
AA Change: M107T

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000095770
Gene: ENSMUSG00000073920
AA Change: M107T

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.9e-74 PFAM
Pfam:7TM_GPCR_Srsx 41 312 2e-9 PFAM
Pfam:7tm_1 47 297 1.1e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211165
Predicted Effect possibly damaging
Transcript: ENSMUST00000214876
AA Change: M107T

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215864
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh4a1 G T 4: 139,369,471 (GRCm39) E341* probably null Het
Alpk3 A G 7: 80,707,390 (GRCm39) R5G unknown Het
Arhgef10l C T 4: 140,307,726 (GRCm39) V113M probably damaging Het
Brca2 T A 5: 150,465,852 (GRCm39) I1872K probably benign Het
Cdk17 C A 10: 93,053,907 (GRCm39) P134T probably benign Het
Cerk A G 15: 86,030,517 (GRCm39) S35P possibly damaging Het
Cfap126 T C 1: 170,954,305 (GRCm39) V174A possibly damaging Het
Cfhr1 T C 1: 139,478,606 (GRCm39) T255A probably benign Het
Clcn1 A G 6: 42,287,606 (GRCm39) probably benign Het
Copz1 A G 15: 103,206,318 (GRCm39) E151G probably benign Het
Cubn G A 2: 13,494,747 (GRCm39) Q101* probably null Het
Eri1 T C 8: 35,958,397 (GRCm39) E12G possibly damaging Het
Fut9 A G 4: 25,619,867 (GRCm39) F316L possibly damaging Het
Garin1a A T 6: 29,285,979 (GRCm39) H146L probably damaging Het
Gm973 A G 1: 59,669,396 (GRCm39) I816V probably benign Het
Itln1 A G 1: 171,362,348 (GRCm39) M11T probably benign Het
Klc2 C T 19: 5,159,825 (GRCm39) R458Q probably damaging Het
Lrrc8b A T 5: 105,633,826 (GRCm39) E766V probably damaging Het
Mmadhc A T 2: 50,171,197 (GRCm39) I205N probably damaging Het
Myo10 A G 15: 25,732,149 (GRCm39) I342V probably benign Het
Ncapg T A 5: 45,851,195 (GRCm39) V796D probably damaging Het
Olfm3 A C 3: 114,890,649 (GRCm39) D134A possibly damaging Het
Or3a1c T C 11: 74,046,279 (GRCm39) C100R probably damaging Het
Or51t4 T A 7: 102,598,446 (GRCm39) I248N probably damaging Het
Phldb3 A G 7: 24,326,751 (GRCm39) E593G probably damaging Het
Plcg1 T A 2: 160,589,699 (GRCm39) D74E probably damaging Het
Plekhm3 T C 1: 64,961,407 (GRCm39) D283G probably benign Het
Pnpla6 C A 8: 3,572,616 (GRCm39) T279N probably damaging Het
Prkcq G A 2: 11,265,644 (GRCm39) probably benign Het
Rbm11 G A 16: 75,397,510 (GRCm39) A147T probably benign Het
Rnf103 A G 6: 71,487,366 (GRCm39) K666E probably damaging Het
Selenos A G 7: 65,730,137 (GRCm39) Y45C probably damaging Het
Septin11 A G 5: 93,309,085 (GRCm39) Y255C probably damaging Het
Serpinb3c T C 1: 107,199,702 (GRCm39) H273R probably benign Het
Slc35f2 A G 9: 53,713,909 (GRCm39) D141G probably damaging Het
Sntg2 A T 12: 30,362,648 (GRCm39) Y33N probably damaging Het
Snx19 C A 9: 30,373,649 (GRCm39) T904K probably damaging Het
Tenm4 A G 7: 96,544,716 (GRCm39) Y2244C probably damaging Het
Tescl A G 7: 24,032,872 (GRCm39) V151A probably damaging Het
Tnrc18 C T 5: 142,757,816 (GRCm39) V902M unknown Het
Trmt13 A G 3: 116,375,113 (GRCm39) L465S probably damaging Het
Ube2j2 T G 4: 156,041,788 (GRCm39) V249G probably damaging Het
Zan T C 5: 137,391,273 (GRCm39) K4737R unknown Het
Zc3h6 T C 2: 128,853,795 (GRCm39) I430T probably damaging Het
Zfp750 G A 11: 121,403,819 (GRCm39) S352L probably benign Het
Zfp819 A G 7: 43,265,846 (GRCm39) K34E probably benign Het
Other mutations in Or56b2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01161:Or56b2 APN 7 104,337,588 (GRCm39) missense probably benign 0.00
IGL01578:Or56b2 APN 7 104,338,052 (GRCm39) missense probably benign 0.01
IGL01595:Or56b2 APN 7 104,337,285 (GRCm39) missense possibly damaging 0.78
IGL02086:Or56b2 APN 7 104,337,634 (GRCm39) missense probably benign 0.38
IGL02421:Or56b2 APN 7 104,337,740 (GRCm39) missense probably benign 0.00
IGL02874:Or56b2 APN 7 104,337,230 (GRCm39) missense probably benign 0.16
IGL03120:Or56b2 APN 7 104,337,609 (GRCm39) missense probably benign 0.28
R0735:Or56b2 UTSW 7 104,338,026 (GRCm39) missense probably damaging 0.97
R1246:Or56b2 UTSW 7 104,337,371 (GRCm39) missense possibly damaging 0.69
R1654:Or56b2 UTSW 7 104,337,420 (GRCm39) missense probably benign 0.12
R1994:Or56b2 UTSW 7 104,337,690 (GRCm39) missense probably benign 0.12
R3686:Or56b2 UTSW 7 104,337,599 (GRCm39) missense probably benign 0.00
R5140:Or56b2 UTSW 7 104,338,107 (GRCm39) missense probably benign 0.01
R5627:Or56b2 UTSW 7 104,337,377 (GRCm39) missense probably benign 0.02
R6338:Or56b2 UTSW 7 104,337,378 (GRCm39) missense possibly damaging 0.53
R8810:Or56b2 UTSW 7 104,337,387 (GRCm39) missense probably damaging 0.97
R8954:Or56b2 UTSW 7 104,337,900 (GRCm39) nonsense probably null
R9261:Or56b2 UTSW 7 104,337,260 (GRCm39) missense probably benign 0.00
Posted On 2014-01-21