Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01733:Taar8c'

105569

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taar8c

Ensembl Gene

ENSMUSG00000100004

Gene Name

trace amine-associated receptor 8C

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL01733

Quality Score

Status

Chromosome

Chromosomal Location

23976776-23977810 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23977155 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 219 (I219T)

Ref Sequence

ENSEMBL: ENSMUSP00000133193 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170267]

AlphaFold

Q5QD05

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170267
AA Change: I219T

PolyPhen 2 Score 0.862 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000133193
Gene: ENSMUSG00000100004
AA Change: I219T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	40	244	2.7e-8	PFAM
Pfam:7TM_GPCR_Srsx	42	327	4.9e-15	PFAM
Pfam:7tm_1	48	312	2.3e-57	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcd2	C	T	15: 91,075,817 (GRCm39)		probably benign	Het
Aco1	T	G	4: 40,175,738 (GRCm39)		probably benign	Het
Brinp3	T	C	1: 146,390,541 (GRCm39)	V29A	probably benign	Het
Brsk1	T	C	7: 4,709,071 (GRCm39)	Y361H	probably damaging	Het
Ccdc178	G	T	18: 22,157,869 (GRCm39)		probably benign	Het
Ces1f	A	G	8: 93,996,642 (GRCm39)	I217T	probably damaging	Het
Col6a6	T	A	9: 105,586,454 (GRCm39)	T1856S	possibly damaging	Het
Cuedc2	C	A	19: 46,321,112 (GRCm39)	V7F	probably damaging	Het
Cyp2d34	C	T	15: 82,502,861 (GRCm39)	V122M	possibly damaging	Het
Ddx60	T	C	8: 62,436,899 (GRCm39)	S949P	probably damaging	Het
Dlg5	G	A	14: 24,220,517 (GRCm39)	R554W	probably damaging	Het
Fig4	A	T	10: 41,153,389 (GRCm39)	N137K	possibly damaging	Het
Gpr155	C	T	2: 73,183,956 (GRCm39)		probably null	Het
Grk6	A	C	13: 55,599,204 (GRCm39)	N168T	possibly damaging	Het
Hfe	T	G	13: 23,890,848 (GRCm39)	K97T	possibly damaging	Het
Hsd3b2	C	T	3: 98,623,801 (GRCm39)	E26K	probably damaging	Het
Impg1	A	G	9: 80,249,206 (GRCm39)	S666P	probably damaging	Het
Itpkb	T	G	1: 180,160,734 (GRCm39)	S287A	possibly damaging	Het
Kcnh5	T	C	12: 75,011,966 (GRCm39)	D651G	probably benign	Het
Lemd3	C	T	10: 120,769,568 (GRCm39)	W588*	probably null	Het
Lepr	A	G	4: 101,622,279 (GRCm39)	T404A	probably benign	Het
Metap1d	A	G	2: 71,341,777 (GRCm39)	I124V	probably damaging	Het
Mrpl33	T	C	5: 31,779,733 (GRCm39)	V54A	probably benign	Het
Mybl1	A	T	1: 9,755,935 (GRCm39)	S205T	possibly damaging	Het
Mybpc2	T	A	7: 44,155,622 (GRCm39)	D877V	probably benign	Het
Nxph2	T	C	2: 23,290,137 (GRCm39)	V163A	probably benign	Het
Pakap	G	T	4: 57,856,488 (GRCm39)	V606L	probably benign	Het
Pex16	C	T	2: 92,209,173 (GRCm39)	P192S	probably damaging	Het
Ptprq	C	A	10: 107,498,460 (GRCm39)	M872I	probably benign	Het
Ripor1	C	T	8: 106,342,378 (GRCm39)	R150W	possibly damaging	Het
Spns2	A	T	11: 72,347,336 (GRCm39)	V423E	possibly damaging	Het
St6galnac2	C	T	11: 116,575,945 (GRCm39)	D169N	probably damaging	Het
Stoml3	A	G	3: 53,405,548 (GRCm39)	I50V	probably benign	Het
Ubap2	A	C	4: 41,195,862 (GRCm39)		probably benign	Het
Zfat	T	C	15: 68,052,579 (GRCm39)	D398G	probably damaging	Het

Other mutations in Taar8c

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00816:Taar8c	APN	10	23,977,173 (GRCm39)	missense	probably damaging	0.99
R0669:Taar8c	UTSW	10	23,977,401 (GRCm39)	missense	probably damaging	1.00
R1186:Taar8c	UTSW	10	23,977,463 (GRCm39)	nonsense	probably null
R1452:Taar8c	UTSW	10	23,977,508 (GRCm39)	missense	probably benign	0.00
R2256:Taar8c	UTSW	10	23,976,969 (GRCm39)	missense	probably benign	0.01
R4364:Taar8c	UTSW	10	23,977,477 (GRCm39)	missense	probably benign	0.02
R4904:Taar8c	UTSW	10	23,977,147 (GRCm39)	missense	probably benign	0.01
R5314:Taar8c	UTSW	10	23,977,246 (GRCm39)	missense	probably damaging	1.00
R6163:Taar8c	UTSW	10	23,977,116 (GRCm39)	missense	probably benign	0.00
R6631:Taar8c	UTSW	10	23,977,701 (GRCm39)	missense	probably benign	0.01
R7428:Taar8c	UTSW	10	23,977,446 (GRCm39)	missense	probably damaging	1.00
R7497:Taar8c	UTSW	10	23,977,116 (GRCm39)	missense	probably benign	0.00
R7525:Taar8c	UTSW	10	23,977,764 (GRCm39)	missense	probably benign	0.03
R8122:Taar8c	UTSW	10	23,977,107 (GRCm39)	missense	probably benign	0.14
R8280:Taar8c	UTSW	10	23,976,835 (GRCm39)	missense	probably benign	0.37
R8293:Taar8c	UTSW	10	23,977,015 (GRCm39)	missense	probably benign	0.00
R8772:Taar8c	UTSW	10	23,977,705 (GRCm39)	missense	probably benign
R9165:Taar8c	UTSW	10	23,977,500 (GRCm39)	missense	probably damaging	1.00
Z1177:Taar8c	UTSW	10	23,977,305 (GRCm39)	missense	probably benign	0.37
Z1177:Taar8c	UTSW	10	23,977,148 (GRCm39)	missense	probably benign	0.15

Posted On

2014-01-21