Incidental Mutation 'IGL01734:Prss42'
ID 105614
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prss42
Ensembl Gene ENSMUSG00000044664
Gene Name serine protease 42
Synonyms Tessp2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL01734
Quality Score
Status
Chromosome 9
Chromosomal Location 110627234-110632822 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 110627411 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Glutamine at position 49 (P49Q)
Ref Sequence ENSEMBL: ENSMUSP00000041088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035715]
AlphaFold Q8VIF2
Predicted Effect probably benign
Transcript: ENSMUST00000035715
AA Change: P49Q

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000041088
Gene: ENSMUSG00000044664
AA Change: P49Q

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Tryp_SPc 78 310 2.12e-87 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932442E05Rik T A 10: 118,697,371 (GRCm39) W210R possibly damaging Het
Aknad1 T C 3: 108,659,217 (GRCm39) M77T probably benign Het
Aox1 A T 1: 58,393,469 (GRCm39) I1210F possibly damaging Het
Brd8 A T 18: 34,747,858 (GRCm39) probably benign Het
Cdh23 T C 10: 60,139,292 (GRCm39) D3307G probably benign Het
Chsy1 T C 7: 65,821,058 (GRCm39) I431T probably damaging Het
Cobl A G 11: 12,204,980 (GRCm39) probably benign Het
Col28a1 T C 6: 8,158,134 (GRCm39) D308G probably damaging Het
Csmd3 A G 15: 48,048,700 (GRCm39) Y568H probably damaging Het
Dmrt3 T C 19: 25,599,947 (GRCm39) I264T probably damaging Het
Dusp22 G T 13: 30,880,235 (GRCm39) C52F probably damaging Het
Fbxw22 A C 9: 109,212,993 (GRCm39) M318R probably damaging Het
Ffar4 C T 19: 38,102,295 (GRCm39) T310M probably damaging Het
Fn1 A G 1: 71,658,644 (GRCm39) V1138A probably damaging Het
Glt6d1 T A 2: 25,684,505 (GRCm39) Y167F probably benign Het
Hydin T A 8: 111,217,421 (GRCm39) Y1436* probably null Het
Il12a G A 3: 68,598,888 (GRCm39) C2Y possibly damaging Het
Inpp5a T C 7: 139,034,006 (GRCm39) Y38H possibly damaging Het
Jmy A C 13: 93,596,159 (GRCm39) L490R probably damaging Het
Kif26a T A 12: 112,143,262 (GRCm39) L1172H probably benign Het
Kmo A T 1: 175,482,668 (GRCm39) M331L probably benign Het
Lonp1 G A 17: 56,923,026 (GRCm39) T627M probably damaging Het
Lrrc41 T C 4: 115,950,331 (GRCm39) probably null Het
Mast4 A T 13: 102,874,123 (GRCm39) S1556R probably damaging Het
Mmel1 A G 4: 154,976,408 (GRCm39) N490S probably benign Het
Mpped2 A G 2: 106,614,158 (GRCm39) D164G probably damaging Het
Nap1l1 A G 10: 111,328,760 (GRCm39) T230A probably benign Het
Nrap C A 19: 56,338,741 (GRCm39) A913S probably damaging Het
Nudt16 G T 9: 105,008,707 (GRCm39) Q65K probably benign Het
Or1e23 C A 11: 73,407,462 (GRCm39) A188S probably benign Het
Or5ac17 T G 16: 59,036,792 (GRCm39) L61F probably benign Het
Or5ac19 T A 16: 59,089,213 (GRCm39) K272N probably benign Het
Or5al5 T A 2: 85,962,012 (GRCm39) probably benign Het
Or6c76b T A 10: 129,692,671 (GRCm39) C95S probably benign Het
Parp14 A G 16: 35,678,970 (GRCm39) F333L probably benign Het
Pi4ka G T 16: 17,115,124 (GRCm39) Q1422K probably benign Het
Polr3c T C 3: 96,620,836 (GRCm39) E494G probably damaging Het
Ptpra C T 2: 130,385,997 (GRCm39) T568I probably damaging Het
Ring1 T C 17: 34,242,294 (GRCm39) D71G probably damaging Het
Siae T A 9: 37,542,782 (GRCm39) S193T probably damaging Het
Slf2 T C 19: 44,961,706 (GRCm39) probably null Het
Spinkl T A 18: 44,307,639 (GRCm39) K7N possibly damaging Het
Tbk1 G A 10: 121,407,888 (GRCm39) R82* probably null Het
Tcf12 T C 9: 71,829,930 (GRCm39) probably null Het
Tcl1b5 G A 12: 105,145,214 (GRCm39) M59I probably benign Het
Thumpd3 C A 6: 113,043,806 (GRCm39) T407K probably damaging Het
Timm29 T C 9: 21,505,031 (GRCm39) V233A probably damaging Het
Tns3 A G 11: 8,469,192 (GRCm39) probably benign Het
Ubash3b T C 9: 40,937,543 (GRCm39) probably benign Het
Ugdh G T 5: 65,580,031 (GRCm39) T253K probably benign Het
Zfp143 T A 7: 109,671,416 (GRCm39) probably benign Het
Zfp738 A G 13: 67,831,563 (GRCm39) probably benign Het
Other mutations in Prss42
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02221:Prss42 APN 9 110,632,243 (GRCm39) missense possibly damaging 0.94
IGL02376:Prss42 APN 9 110,632,175 (GRCm39) missense possibly damaging 0.92
IGL02892:Prss42 APN 9 110,628,458 (GRCm39) missense probably damaging 1.00
R0446:Prss42 UTSW 9 110,628,341 (GRCm39) missense possibly damaging 0.82
R1672:Prss42 UTSW 9 110,629,996 (GRCm39) missense probably damaging 1.00
R4840:Prss42 UTSW 9 110,628,369 (GRCm39) missense probably damaging 1.00
R5622:Prss42 UTSW 9 110,628,490 (GRCm39) critical splice donor site probably null
R6527:Prss42 UTSW 9 110,629,924 (GRCm39) missense possibly damaging 0.46
R7454:Prss42 UTSW 9 110,627,897 (GRCm39) missense probably benign 0.00
R7956:Prss42 UTSW 9 110,628,402 (GRCm39) missense probably damaging 0.97
R8404:Prss42 UTSW 9 110,629,984 (GRCm39) missense probably damaging 1.00
R8502:Prss42 UTSW 9 110,629,984 (GRCm39) missense probably damaging 1.00
R9142:Prss42 UTSW 9 110,628,228 (GRCm39) missense possibly damaging 0.94
Posted On 2014-01-21