Incidental Mutation 'IGL01734:Dusp22'
ID105616
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dusp22
Ensembl Gene ENSMUSG00000069255
Gene Namedual specificity phosphatase 22
SynonymsJKAP, JSP1, 1110028K04Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.294) question?
Stock #IGL01734
Quality Score
Status
Chromosome13
Chromosomal Location30659999-30711231 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 30696252 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Phenylalanine at position 52 (C52F)
Ref Sequence ENSEMBL: ENSMUSP00000105939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091672] [ENSMUST00000095914] [ENSMUST00000110310] [ENSMUST00000221725]
Predicted Effect probably damaging
Transcript: ENSMUST00000091672
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000089260
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000095914
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000093603
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
DSPc 4 141 2.62e-48 SMART
low complexity region 180 194 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110310
AA Change: C52F

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000105939
Gene: ENSMUSG00000069255
AA Change: C52F

DomainStartEndE-ValueType
Pfam:DSPc 12 89 2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220748
Predicted Effect probably benign
Transcript: ENSMUST00000221725
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932442E05Rik T A 10: 118,861,466 W210R possibly damaging Het
Aknad1 T C 3: 108,751,901 M77T probably benign Het
Aox2 A T 1: 58,354,310 I1210F possibly damaging Het
Brd8 A T 18: 34,614,805 probably benign Het
Cdh23 T C 10: 60,303,513 D3307G probably benign Het
Chsy1 T C 7: 66,171,310 I431T probably damaging Het
Cobl A G 11: 12,254,980 probably benign Het
Col28a1 T C 6: 8,158,134 D308G probably damaging Het
Csmd3 A G 15: 48,185,304 Y568H probably damaging Het
Dmrt3 T C 19: 25,622,583 I264T probably damaging Het
Fbxw22 A C 9: 109,383,925 M318R probably damaging Het
Ffar4 C T 19: 38,113,847 T310M probably damaging Het
Fn1 A G 1: 71,619,485 V1138A probably damaging Het
Glt6d1 T A 2: 25,794,493 Y167F probably benign Het
Hydin T A 8: 110,490,789 Y1436* probably null Het
Il12a G A 3: 68,691,555 C2Y possibly damaging Het
Inpp5a T C 7: 139,454,090 Y38H possibly damaging Het
Jmy A C 13: 93,459,651 L490R probably damaging Het
Kif26a T A 12: 112,176,828 L1172H probably benign Het
Kmo A T 1: 175,655,102 M331L probably benign Het
Lonp1 G A 17: 56,616,026 T627M probably damaging Het
Lrrc41 T C 4: 116,093,134 probably null Het
Mast4 A T 13: 102,737,615 S1556R probably damaging Het
Mmel1 A G 4: 154,891,951 N490S probably benign Het
Mpped2 A G 2: 106,783,813 D164G probably damaging Het
Nap1l1 A G 10: 111,492,899 T230A probably benign Het
Nrap C A 19: 56,350,309 A913S probably damaging Het
Nudt16 G T 9: 105,131,508 Q65K probably benign Het
Olfr1039 T A 2: 86,131,668 probably benign Het
Olfr199 T G 16: 59,216,429 L61F probably benign Het
Olfr201 T A 16: 59,268,850 K272N probably benign Het
Olfr382 C A 11: 73,516,636 A188S probably benign Het
Olfr813 T A 10: 129,856,802 C95S probably benign Het
Parp14 A G 16: 35,858,600 F333L probably benign Het
Pi4ka G T 16: 17,297,260 Q1422K probably benign Het
Polr3c T C 3: 96,713,520 E494G probably damaging Het
Prss42 C A 9: 110,798,343 P49Q probably benign Het
Ptpra C T 2: 130,544,077 T568I probably damaging Het
Ring1 T C 17: 34,023,320 D71G probably damaging Het
Siae T A 9: 37,631,486 S193T probably damaging Het
Slf2 T C 19: 44,973,267 probably null Het
Spinkl T A 18: 44,174,572 K7N possibly damaging Het
Tbk1 G A 10: 121,571,983 R82* probably null Het
Tcf12 T C 9: 71,922,648 probably null Het
Tcl1b5 G A 12: 105,178,955 M59I probably benign Het
Thumpd3 C A 6: 113,066,845 T407K probably damaging Het
Timm29 T C 9: 21,593,735 V233A probably damaging Het
Tns3 A G 11: 8,519,192 probably benign Het
Ubash3b T C 9: 41,026,247 probably benign Het
Ugdh G T 5: 65,422,688 T253K probably benign Het
Zfp143 T A 7: 110,072,209 probably benign Het
Zfp738 A G 13: 67,683,444 probably benign Het
Other mutations in Dusp22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01528:Dusp22 APN 13 30705628 missense probably benign 0.00
IGL01835:Dusp22 APN 13 30708683 unclassified probably null
IGL02563:Dusp22 APN 13 30705645 missense possibly damaging 0.91
R0310:Dusp22 UTSW 13 30705658 missense probably damaging 0.96
R1491:Dusp22 UTSW 13 30708815 missense probably benign
R4211:Dusp22 UTSW 13 30708743 missense probably benign 0.32
R4884:Dusp22 UTSW 13 30668830 missense probably benign 0.21
R5877:Dusp22 UTSW 13 30707961 missense probably damaging 1.00
Posted On2014-01-21