Incidental Mutation 'IGL01736:Ceacam10'
ID105697
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ceacam10
Ensembl Gene ENSMUSG00000054169
Gene Namecarcinoembryonic antigen-related cell adhesion molecule 10
SynonymsCea10, Bgp3
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01736
Quality Score
Status
Chromosome7
Chromosomal Location24777206-24784657 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 24781110 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 102 (Y102C)
Ref Sequence ENSEMBL: ENSMUSP00000146217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038069] [ENSMUST00000206847]
Predicted Effect unknown
Transcript: ENSMUST00000038069
AA Change: Y222C
SMART Domains Protein: ENSMUSP00000037036
Gene: ENSMUSG00000054169
AA Change: Y222C

DomainStartEndE-ValueType
IG_like 42 141 1.23e1 SMART
low complexity region 142 151 N/A INTRINSIC
IG_like 160 261 4.41e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206380
Predicted Effect probably damaging
Transcript: ENSMUST00000206847
AA Change: Y102C

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000206850
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Animals homozygous for a mutation in this gene are fertile and viable. However, a small but significant 23% reduction in litter size was observed in homozygous matings. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,188,442 T290A possibly damaging Het
Apip G A 2: 103,087,141 V62M probably damaging Het
Appbp2 T C 11: 85,214,317 K141R possibly damaging Het
Arhgef18 T A 8: 3,451,624 probably benign Het
B3galt2 A G 1: 143,646,845 T240A probably benign Het
Bivm A T 1: 44,141,813 N385I probably damaging Het
Brd4 A T 17: 32,198,675 probably benign Het
Cage1 T C 13: 38,022,813 D352G possibly damaging Het
Diaph3 T C 14: 86,918,846 D677G probably benign Het
Dis3l T C 9: 64,319,254 probably null Het
Dnah6 C T 6: 73,188,377 V582M probably benign Het
Fndc3b A G 3: 27,467,403 L541P probably damaging Het
Folh1 T C 7: 86,742,236 T384A possibly damaging Het
Gdpd3 T C 7: 126,766,523 L18P probably damaging Het
Grxcr2 T A 18: 41,998,982 K7N probably damaging Het
Gulo A G 14: 65,996,876 F246L probably benign Het
Inpp4b A T 8: 81,997,339 D500V probably benign Het
Ints4 C T 7: 97,526,642 L647F probably benign Het
Kif17 T A 4: 138,286,565 L264Q possibly damaging Het
Kif21a T C 15: 90,959,745 N1104S possibly damaging Het
Ly6e T G 15: 74,958,697 L132R probably benign Het
Mis18bp1 T A 12: 65,138,678 H905L probably damaging Het
Nr2f2 A G 7: 70,354,698 S269P probably damaging Het
Olfr1176 T A 2: 88,340,427 N287K probably damaging Het
Olfr1360 C A 13: 21,674,617 C109F probably benign Het
Olfr1394 G A 11: 49,160,527 C171Y probably damaging Het
Pde8b T C 13: 95,030,402 I757V probably damaging Het
Psg23 A T 7: 18,612,197 I191N possibly damaging Het
Slc12a4 A T 8: 105,945,843 probably null Het
Snph A T 2: 151,594,173 Y209* probably null Het
Tnfaip3 T C 10: 19,006,901 H256R probably damaging Het
Tnip3 T A 6: 65,596,123 probably benign Het
Ttc3 T A 16: 94,442,527 F1130Y probably damaging Het
Twnk T G 19: 45,010,188 V515G probably damaging Het
Usp24 T A 4: 106,423,461 I2324K probably benign Het
Vwa7 T C 17: 35,019,851 F305S probably damaging Het
Ythdc2 A T 18: 44,850,668 Q567L probably damaging Het
Zbtb11 T A 16: 55,998,160 I649K probably damaging Het
Zbtb49 T C 5: 38,200,860 Y683C probably damaging Het
Zfhx4 A T 3: 5,244,092 M793L possibly damaging Het
Zmym6 T G 4: 127,108,644 I556R probably damaging Het
Zswim8 C T 14: 20,714,712 P717S probably benign Het
Other mutations in Ceacam10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02538:Ceacam10 APN 7 24778483 missense probably damaging 1.00
R0040:Ceacam10 UTSW 7 24778264 missense probably damaging 1.00
R0040:Ceacam10 UTSW 7 24778264 missense probably damaging 1.00
R0254:Ceacam10 UTSW 7 24778308 missense probably damaging 0.96
R0396:Ceacam10 UTSW 7 24781014 missense probably damaging 1.00
R0567:Ceacam10 UTSW 7 24778409 missense probably damaging 1.00
R1694:Ceacam10 UTSW 7 24781066 missense probably benign 0.27
R2069:Ceacam10 UTSW 7 24778372 missense probably damaging 1.00
R4425:Ceacam10 UTSW 7 24781008 missense possibly damaging 0.68
R4748:Ceacam10 UTSW 7 24781052 missense probably benign 0.01
R7292:Ceacam10 UTSW 7 24778350 missense probably damaging 1.00
X0052:Ceacam10 UTSW 7 24781025 missense probably benign 0.00
Posted On2014-01-21