Incidental Mutation 'IGL01736:Zbtb11'
ID 105698
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zbtb11
Ensembl Gene ENSMUSG00000022601
Gene Name zinc finger and BTB domain containing 11
Synonyms 9230110G02Rik, ZNF-U69274
Accession Numbers
Essential gene? Probably essential (E-score: 0.972) question?
Stock # IGL01736
Quality Score
Status
Chromosome 16
Chromosomal Location 55794246-55829276 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 55818523 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 649 (I649K)
Ref Sequence ENSEMBL: ENSMUSP00000056923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050248]
AlphaFold G5E8B9
Predicted Effect probably damaging
Transcript: ENSMUST00000050248
AA Change: I649K

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000056923
Gene: ENSMUSG00000022601
AA Change: I649K

DomainStartEndE-ValueType
low complexity region 136 158 N/A INTRINSIC
low complexity region 161 177 N/A INTRINSIC
BTB 214 312 4.77e-13 SMART
low complexity region 371 399 N/A INTRINSIC
ZnF_C2H2 566 588 1.1e-2 SMART
ZnF_C2H2 594 616 2.09e-3 SMART
low complexity region 623 640 N/A INTRINSIC
ZnF_C2H2 648 670 4.47e-3 SMART
ZnF_C2H2 676 698 8.22e-2 SMART
ZnF_C2H2 704 726 2.27e-4 SMART
ZnF_C2H2 732 754 1.28e-3 SMART
ZnF_C2H2 763 785 2.95e-3 SMART
ZnF_C2H2 791 813 7.67e-2 SMART
ZnF_C2H2 819 843 2.95e-3 SMART
ZnF_C2H2 855 877 1.67e-2 SMART
ZnF_C2H2 883 905 3.02e0 SMART
ZnF_C2H2 911 934 9.58e-3 SMART
low complexity region 979 994 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb A G 5: 114,326,503 (GRCm39) T290A possibly damaging Het
Apip G A 2: 102,917,486 (GRCm39) V62M probably damaging Het
Appbp2 T C 11: 85,105,143 (GRCm39) K141R possibly damaging Het
Arhgef18 T A 8: 3,501,624 (GRCm39) probably benign Het
B3galt2 A G 1: 143,522,583 (GRCm39) T240A probably benign Het
Bivm A T 1: 44,180,973 (GRCm39) N385I probably damaging Het
Brd4 A T 17: 32,417,649 (GRCm39) probably benign Het
Cage1 T C 13: 38,206,789 (GRCm39) D352G possibly damaging Het
Ceacam10 A G 7: 24,480,535 (GRCm39) Y102C probably damaging Het
Diaph3 T C 14: 87,156,282 (GRCm39) D677G probably benign Het
Dis3l T C 9: 64,226,536 (GRCm39) probably null Het
Dnah6 C T 6: 73,165,360 (GRCm39) V582M probably benign Het
Fndc3b A G 3: 27,521,552 (GRCm39) L541P probably damaging Het
Folh1 T C 7: 86,391,444 (GRCm39) T384A possibly damaging Het
Gdpd3 T C 7: 126,365,695 (GRCm39) L18P probably damaging Het
Grxcr2 T A 18: 42,132,047 (GRCm39) K7N probably damaging Het
Gulo A G 14: 66,234,325 (GRCm39) F246L probably benign Het
Inpp4b A T 8: 82,723,968 (GRCm39) D500V probably benign Het
Ints4 C T 7: 97,175,849 (GRCm39) L647F probably benign Het
Kif17 T A 4: 138,013,876 (GRCm39) L264Q possibly damaging Het
Kif21a T C 15: 90,843,948 (GRCm39) N1104S possibly damaging Het
Ly6e T G 15: 74,830,546 (GRCm39) L132R probably benign Het
Mis18bp1 T A 12: 65,185,452 (GRCm39) H905L probably damaging Het
Nr2f2 A G 7: 70,004,446 (GRCm39) S269P probably damaging Het
Or2b2b C A 13: 21,858,787 (GRCm39) C109F probably benign Het
Or2o1 G A 11: 49,051,354 (GRCm39) C171Y probably damaging Het
Or5d46 T A 2: 88,170,771 (GRCm39) N287K probably damaging Het
Pde8b T C 13: 95,166,910 (GRCm39) I757V probably damaging Het
Psg23 A T 7: 18,346,122 (GRCm39) I191N possibly damaging Het
Slc12a4 A T 8: 106,672,475 (GRCm39) probably null Het
Snph A T 2: 151,436,093 (GRCm39) Y209* probably null Het
Tnfaip3 T C 10: 18,882,649 (GRCm39) H256R probably damaging Het
Tnip3 T A 6: 65,573,107 (GRCm39) probably benign Het
Ttc3 T A 16: 94,243,386 (GRCm39) F1130Y probably damaging Het
Twnk T G 19: 44,998,627 (GRCm39) V515G probably damaging Het
Usp24 T A 4: 106,280,658 (GRCm39) I2324K probably benign Het
Vwa7 T C 17: 35,238,827 (GRCm39) F305S probably damaging Het
Ythdc2 A T 18: 44,983,735 (GRCm39) Q567L probably damaging Het
Zbtb49 T C 5: 38,358,204 (GRCm39) Y683C probably damaging Het
Zfhx4 A T 3: 5,309,152 (GRCm39) M793L possibly damaging Het
Zmym6 T G 4: 127,002,437 (GRCm39) I556R probably damaging Het
Zswim8 C T 14: 20,764,780 (GRCm39) P717S probably benign Het
Other mutations in Zbtb11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Zbtb11 APN 16 55,820,965 (GRCm39) nonsense probably null
IGL01107:Zbtb11 APN 16 55,826,370 (GRCm39) missense probably damaging 1.00
IGL01341:Zbtb11 APN 16 55,811,294 (GRCm39) missense possibly damaging 0.68
IGL01510:Zbtb11 APN 16 55,810,706 (GRCm39) missense probably damaging 0.99
IGL01611:Zbtb11 APN 16 55,800,973 (GRCm39) missense probably damaging 1.00
IGL01834:Zbtb11 APN 16 55,811,371 (GRCm39) missense probably benign 0.35
IGL02427:Zbtb11 APN 16 55,802,713 (GRCm39) missense possibly damaging 0.95
IGL02441:Zbtb11 APN 16 55,794,552 (GRCm39) missense possibly damaging 0.94
IGL02455:Zbtb11 APN 16 55,821,038 (GRCm39) missense probably damaging 1.00
PIT4544001:Zbtb11 UTSW 16 55,818,556 (GRCm39) nonsense probably null
R0987:Zbtb11 UTSW 16 55,811,071 (GRCm39) missense probably benign 0.00
R1414:Zbtb11 UTSW 16 55,810,923 (GRCm39) nonsense probably null
R1437:Zbtb11 UTSW 16 55,811,983 (GRCm39) critical splice donor site probably null
R1570:Zbtb11 UTSW 16 55,811,178 (GRCm39) missense probably benign
R1658:Zbtb11 UTSW 16 55,794,588 (GRCm39) missense possibly damaging 0.71
R1735:Zbtb11 UTSW 16 55,811,045 (GRCm39) missense probably benign
R2048:Zbtb11 UTSW 16 55,818,372 (GRCm39) missense probably damaging 1.00
R2925:Zbtb11 UTSW 16 55,794,447 (GRCm39) missense probably benign 0.00
R4072:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4075:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R4076:Zbtb11 UTSW 16 55,818,427 (GRCm39) missense possibly damaging 0.89
R5023:Zbtb11 UTSW 16 55,826,428 (GRCm39) missense probably damaging 1.00
R5755:Zbtb11 UTSW 16 55,821,076 (GRCm39) missense probably benign 0.02
R5757:Zbtb11 UTSW 16 55,827,392 (GRCm39) missense probably damaging 1.00
R6218:Zbtb11 UTSW 16 55,818,436 (GRCm39) missense probably benign 0.00
R6313:Zbtb11 UTSW 16 55,810,854 (GRCm39) missense probably benign 0.03
R6461:Zbtb11 UTSW 16 55,827,234 (GRCm39) missense probably damaging 0.99
R6666:Zbtb11 UTSW 16 55,826,615 (GRCm39) missense probably damaging 1.00
R6807:Zbtb11 UTSW 16 55,810,865 (GRCm39) missense probably benign 0.03
R7194:Zbtb11 UTSW 16 55,827,551 (GRCm39) missense probably damaging 1.00
R7424:Zbtb11 UTSW 16 55,810,850 (GRCm39) missense probably benign 0.01
R8022:Zbtb11 UTSW 16 55,826,383 (GRCm39) missense probably damaging 0.99
R8436:Zbtb11 UTSW 16 55,821,022 (GRCm39) nonsense probably null
R8532:Zbtb11 UTSW 16 55,811,252 (GRCm39) missense probably benign 0.03
R8806:Zbtb11 UTSW 16 55,802,637 (GRCm39) missense probably damaging 1.00
R9033:Zbtb11 UTSW 16 55,818,492 (GRCm39) missense probably benign
R9673:Zbtb11 UTSW 16 55,827,336 (GRCm39) missense probably damaging 1.00
RF014:Zbtb11 UTSW 16 55,800,960 (GRCm39) missense probably damaging 0.97
Z1176:Zbtb11 UTSW 16 55,811,865 (GRCm39) nonsense probably null
Posted On 2014-01-21