Incidental Mutation 'IGL01738:Gm10267'
ID105767
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm10267
Ensembl Gene ENSMUSG00000069385
Gene Namepredicted gene 10267
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL01738
Quality Score
Status
Chromosome18
Chromosomal Location44156395-44159873 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 44159275 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Lysine at position 10 (I10K)
Ref Sequence ENSEMBL: ENSMUSP00000089535 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091916] [ENSMUST00000181652]
Predicted Effect possibly damaging
Transcript: ENSMUST00000091916
AA Change: I10K

PolyPhen 2 Score 0.630 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000089535
Gene: ENSMUSG00000069385
AA Change: I10K

DomainStartEndE-ValueType
KAZAL 35 85 5.04e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181652
AA Change: I10K

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000137781
Gene: ENSMUSG00000069385
AA Change: I10K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
KAZAL 35 85 5.04e-10 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik A T 8: 105,710,036 D288V probably damaging Het
Agtr1a G A 13: 30,381,038 V29I probably benign Het
Akap6 G T 12: 52,886,817 C364F probably damaging Het
Calcrl T G 2: 84,370,449 M84L probably benign Het
Cep128 C A 12: 91,230,842 G402C probably damaging Het
Cfap43 A G 19: 47,797,185 L422P probably damaging Het
Cnbd2 C A 2: 156,375,617 probably benign Het
Col27a1 A G 4: 63,263,779 probably benign Het
Cyp3a44 A G 5: 145,794,935 S134P probably damaging Het
Dync2h1 A C 9: 7,114,922 L179R possibly damaging Het
Ell T A 8: 70,581,681 probably null Het
Gfm1 A G 3: 67,456,661 E490G probably benign Het
Glt1d1 T G 5: 127,632,355 probably benign Het
Htra4 A G 8: 25,025,711 V437A probably damaging Het
Ighv1-69 T C 12: 115,623,441 Q24R possibly damaging Het
Igkv14-111 G A 6: 68,256,459 probably benign Het
Ipcef1 A T 10: 6,890,575 I374N probably damaging Het
Iqgap1 T C 7: 80,723,900 D1447G possibly damaging Het
Mast4 A G 13: 102,737,241 F1681S probably damaging Het
Mmp3 A T 9: 7,446,946 N42I possibly damaging Het
Mybpc1 G T 10: 88,570,645 F126L probably damaging Het
Myo1e A G 9: 70,359,370 K631E probably damaging Het
Olfr902 A C 9: 38,449,646 Y258S probably damaging Het
Pcsk5 T A 19: 17,433,780 probably benign Het
Serpina3b T G 12: 104,130,832 L124R probably damaging Het
Srgap2 T C 1: 131,296,426 I95V probably benign Het
Sstr5 A T 17: 25,491,610 I215N probably damaging Het
Top3b G A 16: 16,880,604 V104M probably benign Het
Tspan8 G A 10: 115,817,665 probably null Het
Vmn2r102 A G 17: 19,677,758 Y345C probably damaging Het
Vmn2r17 G A 5: 109,429,498 G472S probably damaging Het
Zmpste24 A T 4: 121,061,111 L438Q probably damaging Het
Other mutations in Gm10267
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0050:Gm10267 UTSW 18 44156453 splice site probably benign
R0050:Gm10267 UTSW 18 44156453 splice site probably benign
R1669:Gm10267 UTSW 18 44157300 missense probably damaging 1.00
R2084:Gm10267 UTSW 18 44157330 missense probably benign 0.00
R4289:Gm10267 UTSW 18 44157264 missense probably damaging 1.00
R4570:Gm10267 UTSW 18 44156425 missense probably benign 0.03
R6837:Gm10267 UTSW 18 44158308 missense probably benign
Posted On2014-01-21