Incidental Mutation 'IGL00820:Fbxw18'
ID10738
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw18
Ensembl Gene ENSMUSG00000074059
Gene NameF-box and WD-40 domain protein 18
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL00820
Quality Score
Status
Chromosome9
Chromosomal Location109676734-109702700 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 109693369 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 144 (T144I)
Ref Sequence ENSEMBL: ENSMUSP00000095962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098359]
Predicted Effect probably damaging
Transcript: ENSMUST00000098359
AA Change: T144I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000095962
Gene: ENSMUSG00000074059
AA Change: T144I

DomainStartEndE-ValueType
FBOX 8 48 4.13e-6 SMART
Blast:WD40 140 179 2e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik A T 4: 41,507,178 L206Q probably damaging Het
Abcg3 T A 5: 104,936,012 I631F probably benign Het
Baiap3 T C 17: 25,248,690 D314G probably benign Het
Ccl1 T C 11: 82,178,088 E41G possibly damaging Het
Ephx1 T C 1: 180,999,821 Y89C possibly damaging Het
Galt C T 4: 41,758,570 A357V probably benign Het
Gfra1 T C 19: 58,263,905 probably benign Het
Hivep1 A T 13: 42,183,818 I2458L probably benign Het
Itga8 A G 2: 12,232,892 V339A possibly damaging Het
Klk1b8 T C 7: 43,954,786 I226T probably benign Het
Mfsd6 C T 1: 52,708,306 V467M probably damaging Het
Mrpl16 T C 19: 11,774,413 V179A probably benign Het
Olfr603 G A 7: 103,383,465 T179I probably damaging Het
Pnpla6 A G 8: 3,532,358 T693A possibly damaging Het
Ptpn2 A C 18: 67,675,792 I318R possibly damaging Het
Slc17a2 A G 13: 23,819,334 H285R probably benign Het
Slit2 G A 5: 47,989,151 E95K possibly damaging Het
Sptb A G 12: 76,632,477 L68P probably damaging Het
Stxbp6 G A 12: 44,861,346 T163I probably damaging Het
Tex15 A G 8: 33,579,006 probably benign Het
Tti1 T C 2: 158,008,968 E117G probably damaging Het
Ube4b T C 4: 149,352,921 probably benign Het
Wipi1 A C 11: 109,583,119 probably benign Het
Zan A T 5: 137,386,364 C5133S unknown Het
Other mutations in Fbxw18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Fbxw18 APN 9 109693343 missense probably benign 0.00
IGL01447:Fbxw18 APN 9 109701607 missense probably damaging 1.00
IGL01511:Fbxw18 APN 9 109688821 missense possibly damaging 0.83
IGL01956:Fbxw18 APN 9 109693357 missense probably damaging 0.98
IGL02089:Fbxw18 APN 9 109701322 missense probably benign 0.00
R0004:Fbxw18 UTSW 9 109701313 missense probably damaging 0.96
R0124:Fbxw18 UTSW 9 109691515 missense probably benign 0.00
R0375:Fbxw18 UTSW 9 109688839 missense possibly damaging 0.63
R1652:Fbxw18 UTSW 9 109690627 missense probably benign 0.35
R2153:Fbxw18 UTSW 9 109693370 missense probably damaging 1.00
R2294:Fbxw18 UTSW 9 109676797 missense probably damaging 1.00
R3738:Fbxw18 UTSW 9 109688913 missense possibly damaging 0.57
R4706:Fbxw18 UTSW 9 109690517 missense probably benign 0.00
R4982:Fbxw18 UTSW 9 109702651 start gained probably benign
R4990:Fbxw18 UTSW 9 109688393 missense probably damaging 0.99
R5314:Fbxw18 UTSW 9 109693178 missense possibly damaging 0.90
R5520:Fbxw18 UTSW 9 109691521 missense probably benign 0.00
R5634:Fbxw18 UTSW 9 109676803 missense possibly damaging 0.49
R5718:Fbxw18 UTSW 9 109691568 missense probably benign 0.01
R5894:Fbxw18 UTSW 9 109700167 missense possibly damaging 0.83
R5928:Fbxw18 UTSW 9 109700081 missense probably damaging 0.99
R6175:Fbxw18 UTSW 9 109676879 missense probably damaging 1.00
R6696:Fbxw18 UTSW 9 109688764 missense probably benign 0.09
R6944:Fbxw18 UTSW 9 109702587 missense probably damaging 1.00
Posted On2012-12-06