Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00492:Myrfl'

11000

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Myrfl

Ensembl Gene

ENSMUSG00000034057

Gene Name

myelin regulatory factor-like

Synonyms

Gm239, LOC237558

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00492

Quality Score

Status

Chromosome

Chromosomal Location

116612450-116732784 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 116632011 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 645 (L645F)

Ref Sequence

ENSEMBL: ENSMUSP00000037477 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048229]

AlphaFold

Q3UN70

Predicted Effect

possibly damaging
Transcript: ENSMUST00000048229
AA Change: L645F

PolyPhen 2 Score 0.463 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000037477
Gene: ENSMUSG00000034057
AA Change: L645F

Domain	Start	End	E-Value	Type
Pfam:NDT80_PhoG	252	399	3.4e-29	PFAM
Pfam:Peptidase_S74	446	505	1.6e-18	PFAM
Pfam:MRF_C1	525	560	1.8e-24	PFAM
low complexity region	562	601	N/A	INTRINSIC
transmembrane domain	625	647	N/A	INTRINSIC
low complexity region	663	691	N/A	INTRINSIC
Pfam:MRF_C2	765	903	4e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap29	G	T	3: 121,796,961 (GRCm39)	E108*	probably null	Het
Braf	A	T	6: 39,637,933 (GRCm39)		probably null	Het
Calr3	G	A	8: 73,185,240 (GRCm39)	Q112*	probably null	Het
Dis3	A	G	14: 99,320,110 (GRCm39)	I649T	probably damaging	Het
Dop1b	T	C	16: 93,577,670 (GRCm39)	V65A	probably benign	Het
Dpp4	A	G	2: 62,209,646 (GRCm39)	Y126H	probably damaging	Het
Dtwd2	A	T	18: 49,856,776 (GRCm39)	Y170*	probably null	Het
Efcab7	A	G	4: 99,719,700 (GRCm39)	T61A	probably benign	Het
Fbxl3	G	T	14: 103,332,730 (GRCm39)	L83M	probably damaging	Het
Fbxo17	A	C	7: 28,434,766 (GRCm39)	S184R	probably damaging	Het
Fcf1	T	C	12: 85,029,106 (GRCm39)		probably null	Het
Hcrtr2	T	C	9: 76,153,723 (GRCm39)	Y223C	probably damaging	Het
Kcnn1	A	G	8: 71,300,706 (GRCm39)	F432S	probably benign	Het
Kmt2a	C	T	9: 44,719,231 (GRCm39)		probably benign	Het
Lce1j	T	C	3: 92,696,713 (GRCm39)	T22A	unknown	Het
Lrfn5	T	A	12: 61,890,912 (GRCm39)	S734T	probably benign	Het
Lyst	T	A	13: 13,852,760 (GRCm39)	S2253R	possibly damaging	Het
Msantd5f1	C	T	4: 73,605,570 (GRCm39)	T327I	probably damaging	Het
Nudt9	A	G	5: 104,209,628 (GRCm39)		probably benign	Het
Ostn	T	A	16: 27,140,132 (GRCm39)	M15K	possibly damaging	Het
Psg20	T	C	7: 18,408,536 (GRCm39)	T395A	possibly damaging	Het
Rpf1	G	A	3: 146,218,002 (GRCm39)	H171Y	probably benign	Het
Shprh	A	G	10: 11,063,902 (GRCm39)	E1325G	probably damaging	Het
Slc22a8	G	T	19: 8,571,499 (GRCm39)	V77L	probably benign	Het
Tbck	A	C	3: 132,428,501 (GRCm39)	K285N	probably benign	Het
Vmn1r86	C	T	7: 12,836,468 (GRCm39)	C86Y	possibly damaging	Het
Zdhhc20	A	G	14: 58,111,381 (GRCm39)	I73T	probably damaging	Het
Zfp512b	T	C	2: 181,228,862 (GRCm39)	D701G	probably damaging	Het
Zfp735	T	A	11: 73,602,192 (GRCm39)	Y379N	possibly damaging	Het
Znfx1	G	T	2: 166,878,843 (GRCm39)	H980Q	probably damaging	Het

Other mutations in Myrfl

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00824:Myrfl	APN	10	116,685,264 (GRCm39)	splice site	probably benign
IGL01074:Myrfl	APN	10	116,615,490 (GRCm39)	missense	possibly damaging	0.50
IGL01394:Myrfl	APN	10	116,658,592 (GRCm39)	missense	probably benign	0.01
IGL02283:Myrfl	APN	10	116,613,265 (GRCm39)	missense	probably benign	0.33
IGL02869:Myrfl	APN	10	116,664,909 (GRCm39)	missense	probably damaging	0.98
IGL02878:Myrfl	APN	10	116,613,310 (GRCm39)	missense	possibly damaging	0.70
IGL03112:Myrfl	APN	10	116,639,311 (GRCm39)	missense	probably benign	0.03
F5770:Myrfl	UTSW	10	116,697,435 (GRCm39)	missense	probably damaging	1.00
R0138:Myrfl	UTSW	10	116,685,138 (GRCm39)	missense	probably damaging	0.98
R0402:Myrfl	UTSW	10	116,664,882 (GRCm39)	missense	probably damaging	1.00
R0554:Myrfl	UTSW	10	116,664,878 (GRCm39)	missense	probably damaging	1.00
R0601:Myrfl	UTSW	10	116,612,665 (GRCm39)	missense	probably damaging	1.00
R0790:Myrfl	UTSW	10	116,653,693 (GRCm39)	missense	probably damaging	0.99
R0831:Myrfl	UTSW	10	116,619,114 (GRCm39)	missense	probably benign	0.06
R0931:Myrfl	UTSW	10	116,675,354 (GRCm39)	missense	probably benign	0.01
R0945:Myrfl	UTSW	10	116,639,299 (GRCm39)	splice site	probably benign
R1078:Myrfl	UTSW	10	116,612,637 (GRCm39)	missense	possibly damaging	0.94
R1187:Myrfl	UTSW	10	116,667,447 (GRCm39)	missense	probably damaging	1.00
R1329:Myrfl	UTSW	10	116,613,247 (GRCm39)	critical splice donor site	probably null
R1432:Myrfl	UTSW	10	116,613,332 (GRCm39)	missense	probably damaging	1.00
R1762:Myrfl	UTSW	10	116,634,498 (GRCm39)	missense	probably damaging	1.00
R1827:Myrfl	UTSW	10	116,668,852 (GRCm39)	missense	probably damaging	0.99
R1952:Myrfl	UTSW	10	116,658,716 (GRCm39)	missense	probably benign	0.00
R2138:Myrfl	UTSW	10	116,631,443 (GRCm39)	missense	probably benign	0.00
R2317:Myrfl	UTSW	10	116,675,289 (GRCm39)	missense	possibly damaging	0.77
R2930:Myrfl	UTSW	10	116,653,652 (GRCm39)	missense	probably damaging	1.00
R3405:Myrfl	UTSW	10	116,658,770 (GRCm39)	missense	probably damaging	1.00
R4118:Myrfl	UTSW	10	116,664,870 (GRCm39)	missense	probably damaging	1.00
R4700:Myrfl	UTSW	10	116,613,247 (GRCm39)	critical splice donor site	probably null
R5039:Myrfl	UTSW	10	116,658,616 (GRCm39)	missense	probably damaging	1.00
R5097:Myrfl	UTSW	10	116,653,609 (GRCm39)	missense	probably damaging	1.00
R5138:Myrfl	UTSW	10	116,631,963 (GRCm39)	critical splice donor site	probably null
R5211:Myrfl	UTSW	10	116,634,535 (GRCm39)	missense	probably benign	0.00
R5249:Myrfl	UTSW	10	116,619,138 (GRCm39)	missense	probably benign
R5573:Myrfl	UTSW	10	116,658,661 (GRCm39)	missense	probably damaging	0.98
R6033:Myrfl	UTSW	10	116,685,006 (GRCm39)	missense	probably benign
R6033:Myrfl	UTSW	10	116,685,006 (GRCm39)	missense	probably benign
R6091:Myrfl	UTSW	10	116,685,111 (GRCm39)	missense	probably benign
R6315:Myrfl	UTSW	10	116,658,724 (GRCm39)	missense	possibly damaging	0.81
R6812:Myrfl	UTSW	10	116,668,818 (GRCm39)	missense	probably damaging	1.00
R6867:Myrfl	UTSW	10	116,684,187 (GRCm39)	nonsense	probably null
R7019:Myrfl	UTSW	10	116,617,852 (GRCm39)	critical splice donor site	probably null
R7059:Myrfl	UTSW	10	116,685,111 (GRCm39)	missense	probably benign
R7181:Myrfl	UTSW	10	116,697,448 (GRCm39)	missense	probably damaging	0.96
R7471:Myrfl	UTSW	10	116,697,417 (GRCm39)	missense	possibly damaging	0.95
R7574:Myrfl	UTSW	10	116,667,430 (GRCm39)	nonsense	probably null
R7584:Myrfl	UTSW	10	116,664,902 (GRCm39)	missense	probably damaging	1.00
R7667:Myrfl	UTSW	10	116,675,258 (GRCm39)	missense	possibly damaging	0.88
R7801:Myrfl	UTSW	10	116,684,240 (GRCm39)	missense	probably benign
R8728:Myrfl	UTSW	10	116,634,545 (GRCm39)	nonsense	probably null
R8769:Myrfl	UTSW	10	116,612,696 (GRCm39)	missense	probably damaging	1.00
R8797:Myrfl	UTSW	10	116,613,325 (GRCm39)	missense	probably benign	0.16
R8986:Myrfl	UTSW	10	116,658,746 (GRCm39)	missense	probably damaging	1.00
R9167:Myrfl	UTSW	10	116,667,450 (GRCm39)	missense	probably damaging	0.99
R9366:Myrfl	UTSW	10	116,670,358 (GRCm39)	missense	possibly damaging	0.50
V7582:Myrfl	UTSW	10	116,697,435 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06