Incidental Mutation 'IGL00777:Adgra3'
ID 11090
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgra3
Ensembl Gene ENSMUSG00000029090
Gene Name adhesion G protein-coupled receptor A3
Synonyms Tem5-like, 3830613O22Rik, Gpr125
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00777
Quality Score
Status
Chromosome 5
Chromosomal Location 50117293-50216338 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50183100 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 82 (I82T)
Ref Sequence ENSEMBL: ENSMUSP00000030971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030971]
AlphaFold Q7TT36
Predicted Effect probably damaging
Transcript: ENSMUST00000030971
AA Change: I82T

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000030971
Gene: ENSMUSG00000029090
AA Change: I82T

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
LRR 68 92 1.71e1 SMART
LRR_TYP 93 116 2.27e-4 SMART
LRR_TYP 117 140 4.11e-2 SMART
LRR_TYP 141 164 3.89e-3 SMART
LRRCT 176 225 5.24e-5 SMART
IG 238 331 8.26e-5 SMART
GPS 686 738 4.81e-3 SMART
Pfam:7tm_2 746 1031 1.6e-16 PFAM
low complexity region 1251 1262 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cd72 T C 4: 43,448,365 (GRCm39) Y305C possibly damaging Het
Cldn34c1 T C X: 122,052,570 (GRCm39) L103P probably damaging Het
Dhtkd1 A T 2: 5,934,468 (GRCm39) L234H probably damaging Het
H1f4 T A 13: 23,806,005 (GRCm39) probably benign Het
Hgd A G 16: 37,433,611 (GRCm39) T77A probably damaging Het
Itgad A T 7: 127,803,022 (GRCm39) T1059S probably damaging Het
Klhl20 T C 1: 160,937,325 (GRCm39) T17A probably benign Het
Lct T C 1: 128,215,293 (GRCm39) D1761G probably benign Het
Mmp23 T G 4: 155,735,464 (GRCm39) Y334S possibly damaging Het
Ncapg A G 5: 45,853,107 (GRCm39) S858G possibly damaging Het
Nsd1 G A 13: 55,386,548 (GRCm39) G101E probably damaging Het
Pdia3 T A 2: 121,260,037 (GRCm39) L192Q probably damaging Het
Phex A G X: 155,960,528 (GRCm39) L672P probably damaging Het
Reln A G 5: 22,223,848 (GRCm39) probably null Het
Rfk T A 19: 17,372,700 (GRCm39) V74E probably benign Het
Rubcn A G 16: 32,656,933 (GRCm39) C467R probably damaging Het
Rufy2 G A 10: 62,826,833 (GRCm39) C124Y probably damaging Het
Slc8a1 A G 17: 81,956,009 (GRCm39) I343T probably damaging Het
Smyd4 T A 11: 75,281,634 (GRCm39) M369K probably benign Het
Spata31e2 C A 1: 26,721,173 (GRCm39) D1336Y probably damaging Het
Tmem131l G T 3: 83,806,597 (GRCm39) P1408T probably damaging Het
Tmprss11f A G 5: 86,671,924 (GRCm39) Y423H probably damaging Het
Wdr70 A T 15: 8,049,088 (GRCm39) M303K probably benign Het
Other mutations in Adgra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Adgra3 APN 5 50,159,291 (GRCm39) missense probably damaging 1.00
IGL01455:Adgra3 APN 5 50,144,899 (GRCm39) nonsense probably null
IGL01665:Adgra3 APN 5 50,164,272 (GRCm39) missense possibly damaging 0.64
IGL02151:Adgra3 APN 5 50,136,484 (GRCm39) missense probably benign
IGL02239:Adgra3 APN 5 50,118,054 (GRCm39) missense probably damaging 1.00
IGL02351:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02358:Adgra3 APN 5 50,215,900 (GRCm39) missense probably benign 0.19
IGL02938:Adgra3 APN 5 50,118,659 (GRCm39) missense probably benign 0.01
IGL03028:Adgra3 APN 5 50,174,194 (GRCm39) missense probably benign 0.30
aperture UTSW 5 50,156,487 (GRCm39) nonsense probably null
saltatory UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
ANU74:Adgra3 UTSW 5 50,118,380 (GRCm39) missense probably benign 0.16
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0041:Adgra3 UTSW 5 50,117,901 (GRCm39) missense probably benign 0.09
R0121:Adgra3 UTSW 5 50,183,128 (GRCm39) splice site probably benign
R0125:Adgra3 UTSW 5 50,159,194 (GRCm39) splice site probably benign
R0137:Adgra3 UTSW 5 50,121,182 (GRCm39) splice site probably benign
R0415:Adgra3 UTSW 5 50,119,099 (GRCm39) splice site probably benign
R0479:Adgra3 UTSW 5 50,147,607 (GRCm39) missense probably benign 0.00
R0505:Adgra3 UTSW 5 50,166,676 (GRCm39) critical splice donor site probably null
R0831:Adgra3 UTSW 5 50,128,144 (GRCm39) missense probably damaging 1.00
R0883:Adgra3 UTSW 5 50,118,065 (GRCm39) missense probably damaging 1.00
R0920:Adgra3 UTSW 5 50,118,503 (GRCm39) missense probably benign 0.19
R1139:Adgra3 UTSW 5 50,119,097 (GRCm39) splice site probably null
R1211:Adgra3 UTSW 5 50,164,218 (GRCm39) missense possibly damaging 0.88
R1370:Adgra3 UTSW 5 50,118,129 (GRCm39) missense possibly damaging 0.56
R1530:Adgra3 UTSW 5 50,118,479 (GRCm39) missense probably benign 0.00
R1703:Adgra3 UTSW 5 50,164,117 (GRCm39) missense probably benign 0.00
R1782:Adgra3 UTSW 5 50,129,404 (GRCm39) missense probably benign 0.02
R1843:Adgra3 UTSW 5 50,118,834 (GRCm39) missense probably damaging 1.00
R2157:Adgra3 UTSW 5 50,159,283 (GRCm39) missense possibly damaging 0.87
R2281:Adgra3 UTSW 5 50,159,222 (GRCm39) missense probably benign 0.04
R2385:Adgra3 UTSW 5 50,136,908 (GRCm39) missense possibly damaging 0.95
R2426:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R3084:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3086:Adgra3 UTSW 5 50,170,733 (GRCm39) critical splice donor site probably null
R3409:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3410:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R3411:Adgra3 UTSW 5 50,159,272 (GRCm39) missense probably damaging 1.00
R4301:Adgra3 UTSW 5 50,118,420 (GRCm39) missense possibly damaging 0.94
R4360:Adgra3 UTSW 5 50,147,552 (GRCm39) missense possibly damaging 0.92
R4475:Adgra3 UTSW 5 50,159,240 (GRCm39) missense probably damaging 1.00
R4569:Adgra3 UTSW 5 50,117,905 (GRCm39) missense probably damaging 1.00
R4607:Adgra3 UTSW 5 50,128,081 (GRCm39) missense probably damaging 0.98
R4667:Adgra3 UTSW 5 50,136,298 (GRCm39) missense possibly damaging 0.94
R4671:Adgra3 UTSW 5 50,136,710 (GRCm39) missense probably damaging 1.00
R4886:Adgra3 UTSW 5 50,156,537 (GRCm39) missense probably benign 0.07
R5197:Adgra3 UTSW 5 50,118,096 (GRCm39) missense probably benign 0.01
R5208:Adgra3 UTSW 5 50,168,857 (GRCm39) missense probably damaging 0.99
R5313:Adgra3 UTSW 5 50,118,651 (GRCm39) missense probably benign 0.24
R5435:Adgra3 UTSW 5 50,147,468 (GRCm39) missense probably damaging 0.99
R5663:Adgra3 UTSW 5 50,156,627 (GRCm39) missense probably benign 0.14
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6038:Adgra3 UTSW 5 50,156,487 (GRCm39) nonsense probably null
R6064:Adgra3 UTSW 5 50,117,667 (GRCm39) missense probably damaging 0.97
R6259:Adgra3 UTSW 5 50,156,483 (GRCm39) missense possibly damaging 0.63
R6272:Adgra3 UTSW 5 50,166,791 (GRCm39) missense possibly damaging 0.61
R6293:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6296:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6297:Adgra3 UTSW 5 50,118,189 (GRCm39) missense probably benign 0.21
R6352:Adgra3 UTSW 5 50,147,592 (GRCm39) missense probably benign 0.01
R6352:Adgra3 UTSW 5 50,136,478 (GRCm39) missense probably benign
R6989:Adgra3 UTSW 5 50,164,226 (GRCm39) missense probably damaging 1.00
R7026:Adgra3 UTSW 5 50,118,083 (GRCm39) missense probably benign
R7147:Adgra3 UTSW 5 50,118,587 (GRCm39) missense probably damaging 1.00
R7206:Adgra3 UTSW 5 50,164,238 (GRCm39) missense probably damaging 1.00
R7381:Adgra3 UTSW 5 50,216,116 (GRCm39) start codon destroyed probably null
R7508:Adgra3 UTSW 5 50,174,209 (GRCm39) missense probably benign 0.10
R7538:Adgra3 UTSW 5 50,118,792 (GRCm39) missense probably benign 0.01
R7579:Adgra3 UTSW 5 50,144,977 (GRCm39) missense probably benign
R7951:Adgra3 UTSW 5 50,121,126 (GRCm39) missense probably damaging 1.00
R8269:Adgra3 UTSW 5 50,121,079 (GRCm39) missense probably damaging 0.98
R8458:Adgra3 UTSW 5 50,145,013 (GRCm39) missense probably damaging 0.99
R8486:Adgra3 UTSW 5 50,147,621 (GRCm39) missense probably damaging 0.98
R8912:Adgra3 UTSW 5 50,118,273 (GRCm39) missense possibly damaging 0.61
R8955:Adgra3 UTSW 5 50,118,731 (GRCm39) missense probably benign 0.05
R9108:Adgra3 UTSW 5 50,136,295 (GRCm39) missense probably damaging 1.00
R9112:Adgra3 UTSW 5 50,118,395 (GRCm39) missense probably damaging 1.00
R9191:Adgra3 UTSW 5 50,145,006 (GRCm39) missense possibly damaging 0.88
R9267:Adgra3 UTSW 5 50,155,618 (GRCm39) missense possibly damaging 0.87
R9312:Adgra3 UTSW 5 50,117,900 (GRCm39) missense probably damaging 1.00
R9537:Adgra3 UTSW 5 50,118,207 (GRCm39) missense possibly damaging 0.82
R9614:Adgra3 UTSW 5 50,164,250 (GRCm39) missense probably damaging 1.00
RF005:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF024:Adgra3 UTSW 5 50,170,729 (GRCm39) splice site probably null
RF036:Adgra3 UTSW 5 50,215,983 (GRCm39) small deletion probably benign
X0065:Adgra3 UTSW 5 50,129,304 (GRCm39) missense probably benign
Z1187:Adgra3 UTSW 5 50,136,421 (GRCm39) missense probably damaging 1.00
Z1192:Adgra3 UTSW 5 50,156,623 (GRCm39) missense probably benign 0.00
Posted On 2012-12-06