Incidental Mutation 'IGL00757:Gpr89'
| ID |
11118 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr89
|
| Ensembl Gene |
ENSMUSG00000028096 |
| Gene Name |
G protein-coupled receptor 89 |
| Synonyms |
SH120, 4933412D19Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.445)
|
| Stock # |
IGL00757
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
3 |
| Chromosomal Location |
96775630-96812662 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 96778850 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 408
(T408S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000029738
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000029738]
[ENSMUST00000058865]
[ENSMUST00000107069]
[ENSMUST00000107070]
[ENSMUST00000153256]
|
| AlphaFold |
Q8BS95 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000029738
AA Change: T408S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000029738
Gene: ENSMUSG00000028096
AA Change: T408S
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
4 |
26 |
N/A |
INTRINSIC |
|
transmembrane domain
|
38 |
60 |
N/A |
INTRINSIC |
|
transmembrane domain
|
75 |
97 |
N/A |
INTRINSIC |
|
transmembrane domain
|
110 |
127 |
N/A |
INTRINSIC |
|
Pfam:GPHR_N
|
140 |
207 |
1.1e-31 |
PFAM |
|
Pfam:ABA_GPCR
|
276 |
446 |
4.9e-46 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000058865
|
| SMART Domains |
Protein: ENSMUSP00000058936
Gene: ENSMUSG00000038298
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
18 |
90 |
2.41e-17 |
SMART |
|
PDZ
|
143 |
215 |
1e-14 |
SMART |
|
PDZ
|
251 |
323 |
2.81e-18 |
SMART |
|
PDZ
|
386 |
458 |
4.5e-17 |
SMART |
|
low complexity region
|
505 |
514 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107069
|
| SMART Domains |
Protein: ENSMUSP00000102684
Gene: ENSMUSG00000038298
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
18 |
90 |
2.41e-17 |
SMART |
|
PDZ
|
143 |
215 |
1e-14 |
SMART |
|
PDZ
|
251 |
323 |
2.81e-18 |
SMART |
|
PDZ
|
386 |
458 |
4.5e-17 |
SMART |
|
low complexity region
|
505 |
514 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107070
|
| SMART Domains |
Protein: ENSMUSP00000102685
Gene: ENSMUSG00000038298
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
18 |
90 |
2.41e-17 |
SMART |
|
PDZ
|
143 |
215 |
1e-14 |
SMART |
|
PDZ
|
251 |
323 |
2.81e-18 |
SMART |
|
PDZ
|
386 |
458 |
4.5e-17 |
SMART |
|
low complexity region
|
505 |
514 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000135533
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146645
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153256
|
| SMART Domains |
Protein: ENSMUSP00000118846
Gene: ENSMUSG00000038298
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
18 |
90 |
2.41e-17 |
SMART |
|
PDZ
|
143 |
215 |
1e-14 |
SMART |
|
PDZ
|
251 |
323 |
2.81e-18 |
SMART |
|
PDZ
|
386 |
458 |
4.5e-17 |
SMART |
|
low complexity region
|
505 |
514 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsbg1 |
A |
C |
9: 54,530,003 (GRCm39) |
I231R |
possibly damaging |
Het |
| Ahctf1 |
G |
A |
1: 179,596,696 (GRCm39) |
P94S |
probably damaging |
Het |
| Cldn34b3 |
T |
C |
X: 75,310,978 (GRCm39) |
I182T |
possibly damaging |
Het |
| Cps1 |
T |
A |
1: 67,191,539 (GRCm39) |
|
probably benign |
Het |
| Cwf19l2 |
G |
T |
9: 3,460,054 (GRCm39) |
A781S |
probably damaging |
Het |
| Cyp4v3 |
T |
C |
8: 45,773,652 (GRCm39) |
I172M |
probably damaging |
Het |
| Fcgbpl1 |
T |
G |
7: 27,853,870 (GRCm39) |
C1611W |
probably damaging |
Het |
| Gmnc |
T |
G |
16: 26,782,689 (GRCm39) |
D22A |
probably damaging |
Het |
| Grk2 |
A |
G |
19: 4,339,339 (GRCm39) |
|
probably null |
Het |
| Kctd3 |
A |
G |
1: 188,704,393 (GRCm39) |
S793P |
probably damaging |
Het |
| Lhx1 |
A |
G |
11: 84,410,478 (GRCm39) |
F373S |
probably damaging |
Het |
| Mgl2 |
A |
T |
11: 70,025,976 (GRCm39) |
I71F |
probably damaging |
Het |
| Nbeal1 |
T |
A |
1: 60,234,302 (GRCm39) |
I91N |
possibly damaging |
Het |
| Otog |
T |
A |
7: 45,939,552 (GRCm39) |
D2110E |
probably damaging |
Het |
| Pde9a |
A |
G |
17: 31,662,146 (GRCm39) |
E90G |
probably benign |
Het |
| Plaat5 |
G |
T |
19: 7,591,924 (GRCm39) |
E113D |
possibly damaging |
Het |
| Prdm10 |
T |
C |
9: 31,229,842 (GRCm39) |
V86A |
possibly damaging |
Het |
| R3hdm1 |
T |
G |
1: 128,164,176 (GRCm39) |
I1030R |
probably damaging |
Het |
| Ryr2 |
T |
A |
13: 11,633,490 (GRCm39) |
|
probably null |
Het |
| Serpina1f |
A |
G |
12: 103,659,721 (GRCm39) |
I187T |
probably damaging |
Het |
| Slc22a16 |
C |
T |
10: 40,457,323 (GRCm39) |
T188M |
probably damaging |
Het |
| Spg11 |
T |
C |
2: 121,901,440 (GRCm39) |
H1500R |
probably benign |
Het |
| Sptlc2 |
C |
T |
12: 87,415,842 (GRCm39) |
E62K |
probably damaging |
Het |
| Tgfbr1 |
T |
A |
4: 47,405,581 (GRCm39) |
S326T |
probably damaging |
Het |
| Tgif1 |
A |
G |
17: 71,153,235 (GRCm39) |
Y39H |
probably damaging |
Het |
|
| Other mutations in Gpr89 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00421:Gpr89
|
APN |
3 |
96,805,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Gpr89
|
APN |
3 |
96,800,865 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02417:Gpr89
|
APN |
3 |
96,804,741 (GRCm39) |
nonsense |
probably null |
|
|
explorer
|
UTSW |
3 |
96,787,385 (GRCm39) |
splice site |
probably null |
|
|
R0207:Gpr89
|
UTSW |
3 |
96,778,796 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0650:Gpr89
|
UTSW |
3 |
96,804,640 (GRCm39) |
splice site |
probably benign |
|
|
R0704:Gpr89
|
UTSW |
3 |
96,787,484 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1496:Gpr89
|
UTSW |
3 |
96,812,526 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1869:Gpr89
|
UTSW |
3 |
96,782,975 (GRCm39) |
missense |
probably benign |
0.16 |
|
R1913:Gpr89
|
UTSW |
3 |
96,782,949 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2264:Gpr89
|
UTSW |
3 |
96,779,831 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2276:Gpr89
|
UTSW |
3 |
96,804,743 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3822:Gpr89
|
UTSW |
3 |
96,800,260 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3922:Gpr89
|
UTSW |
3 |
96,798,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4984:Gpr89
|
UTSW |
3 |
96,812,512 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5761:Gpr89
|
UTSW |
3 |
96,800,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6185:Gpr89
|
UTSW |
3 |
96,798,149 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7063:Gpr89
|
UTSW |
3 |
96,783,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7164:Gpr89
|
UTSW |
3 |
96,778,714 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7172:Gpr89
|
UTSW |
3 |
96,787,385 (GRCm39) |
splice site |
probably null |
|
|
R7215:Gpr89
|
UTSW |
3 |
96,787,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7536:Gpr89
|
UTSW |
3 |
96,798,209 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7708:Gpr89
|
UTSW |
3 |
96,787,941 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7849:Gpr89
|
UTSW |
3 |
96,778,806 (GRCm39) |
nonsense |
probably null |
|
|
R8273:Gpr89
|
UTSW |
3 |
96,812,505 (GRCm39) |
missense |
probably benign |
|
|
R9643:Gpr89
|
UTSW |
3 |
96,780,813 (GRCm39) |
missense |
probably damaging |
0.97 |
|
RF019:Gpr89
|
UTSW |
3 |
96,812,509 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2012-12-06 |
Incidental Mutation