Incidental Mutation 'IGL00674:Gpx6'
ID11128
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpx6
Ensembl Gene ENSMUSG00000004341
Gene Nameglutathione peroxidase 6
Synonyms1700020G18Rik, olfactory
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.194) question?
Stock #IGL00674
Quality Score
Status
Chromosome13
Chromosomal Location21312125-21319624 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 21313808 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000004453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004453]
Predicted Effect probably benign
Transcript: ENSMUST00000004453
SMART Domains Protein: ENSMUSP00000004453
Gene: ENSMUSG00000004341

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:GSHPx 40 153 1.2e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136668
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidases catalyze the reduction of a variety of hydroperoxides, using glutathione as a specific electron donor substrate. The mouse and the rat orthologs contain Cys, unlike their human counterpart, which is a selenoprotein containing Sec (selenocysteine) at its active site. Expression of this gene is restricted to embryos and adult olfactory epithelium. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atad2 T A 15: 58,108,386 Q365L possibly damaging Het
Cd2ap A T 17: 42,808,785 N492K probably benign Het
Fam114a1 T A 5: 64,980,004 S97T probably benign Het
Fbxw8 C T 5: 118,095,593 M324I possibly damaging Het
Kbtbd3 A G 9: 4,329,949 T108A probably benign Het
Lrrd1 T C 5: 3,849,773 I26T possibly damaging Het
Mark1 C T 1: 184,912,106 G454S probably benign Het
Mrpl20 T C 4: 155,808,584 F91L probably benign Het
Nt5c3b A T 11: 100,432,909 probably benign Het
Osbpl2 T C 2: 180,150,258 Y252H possibly damaging Het
Pard3 A G 8: 127,388,678 N626D probably damaging Het
Pbrm1 C T 14: 31,118,776 P1612S probably damaging Het
Prl3d3 T C 13: 27,159,131 probably null Het
Sall4 T C 2: 168,755,780 D380G probably damaging Het
Sema3b A C 9: 107,604,041 probably null Het
Spred1 C T 2: 117,177,858 P415L probably damaging Het
Tnc T A 4: 63,965,607 D1958V probably damaging Het
Tnfsf15 A G 4: 63,734,246 probably benign Het
Usp24 T A 4: 106,372,679 probably benign Het
Other mutations in Gpx6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0648:Gpx6 UTSW 13 21318877 missense probably benign 0.44
R0835:Gpx6 UTSW 13 21317068 missense probably damaging 1.00
R1496:Gpx6 UTSW 13 21318920 missense probably benign
R1538:Gpx6 UTSW 13 21313652 missense possibly damaging 0.82
R1839:Gpx6 UTSW 13 21312327 missense probably benign
R2151:Gpx6 UTSW 13 21318971 missense probably damaging 1.00
R2845:Gpx6 UTSW 13 21318875 critical splice acceptor site probably null
R3785:Gpx6 UTSW 13 21313786 missense probably benign 0.02
R3973:Gpx6 UTSW 13 21317658 missense probably damaging 1.00
R3974:Gpx6 UTSW 13 21317658 missense probably damaging 1.00
R3975:Gpx6 UTSW 13 21317658 missense probably damaging 1.00
R4124:Gpx6 UTSW 13 21317645 nonsense probably null
R4707:Gpx6 UTSW 13 21312264 nonsense probably null
R4751:Gpx6 UTSW 13 21317064 missense probably damaging 1.00
R4784:Gpx6 UTSW 13 21312264 nonsense probably null
R4785:Gpx6 UTSW 13 21312264 nonsense probably null
R5002:Gpx6 UTSW 13 21313688 missense probably damaging 1.00
R5403:Gpx6 UTSW 13 21317643 missense probably damaging 1.00
R6004:Gpx6 UTSW 13 21319069 missense probably benign
R6030:Gpx6 UTSW 13 21312340 missense probably benign 0.01
R6030:Gpx6 UTSW 13 21312340 missense probably benign 0.01
X0017:Gpx6 UTSW 13 21317039 missense probably damaging 1.00
Posted On2012-12-06