Incidental Mutation 'IGL00156:Olfr381'
ID1159
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr381
Ensembl Gene ENSMUSG00000072708
Gene Nameolfactory receptor 381
SynonymsGA_x6K02T2P1NL-3646409-3645474, MOR135-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL00156
Quality Score
Status
Chromosome11
Chromosomal Location73484274-73491603 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 73486572 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 84 (N84I)
Ref Sequence ENSEMBL: ENSMUSP00000149355 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078358] [ENSMUST00000119863] [ENSMUST00000214623] [ENSMUST00000215358]
Predicted Effect probably benign
Transcript: ENSMUST00000078358
AA Change: N84I

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077467
Gene: ENSMUSG00000072708
AA Change: N84I

DomainStartEndE-ValueType
Pfam:7tm_1 41 290 1.3e-35 PFAM
Pfam:7tm_4 139 283 5.3e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000119863
AA Change: N84I

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000113846
Gene: ENSMUSG00000072708
AA Change: N84I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.2e-57 PFAM
Pfam:7tm_1 41 290 2e-27 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206673
Predicted Effect probably benign
Transcript: ENSMUST00000214623
AA Change: N84I

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000215358
AA Change: N84I

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 G A 3: 122,062,704 probably null Het
Adamts19 T A 18: 59,024,465 V943E probably damaging Het
C530025M09Rik C A 2: 149,830,726 probably benign Het
Cep192 T G 18: 67,820,336 W475G probably damaging Het
Col28a1 T C 6: 8,014,795 Y870C probably damaging Het
Cyp2a22 A T 7: 26,937,738 M207K probably benign Het
Dpm1 A G 2: 168,210,575 V247A probably benign Het
Glt1d1 T C 5: 127,632,285 M1T probably null Het
Gm9507 A T 10: 77,811,280 C188* probably null Het
Hectd4 T C 5: 121,363,870 V4222A possibly damaging Het
Igkv3-3 T A 6: 70,687,413 S80T possibly damaging Het
Lrrc49 T C 9: 60,601,320 K520E probably damaging Het
Ltbp1 A T 17: 75,385,160 Y1273F probably damaging Het
Lyst T A 13: 13,648,878 H1478Q probably benign Het
Mre11a A G 9: 14,825,208 D518G probably benign Het
Olfr1243 C T 2: 89,528,207 D68N probably damaging Het
Olfr859 T C 9: 19,808,396 I26T probably benign Het
Pkd1l1 T A 11: 8,950,515 S9C probably damaging Het
Prrc2b A G 2: 32,208,719 H681R probably damaging Het
Rapgef1 A G 2: 29,722,269 S644G probably benign Het
Sgce T A 6: 4,689,750 H361L probably damaging Het
Specc1 G T 11: 62,118,009 W117L probably benign Het
Srrm4 A G 5: 116,446,557 S485P possibly damaging Het
Traf2 G T 2: 25,520,451 Y395* probably null Het
Trf A G 9: 103,220,957 I34T probably benign Het
Vdac2 T C 14: 21,838,524 Y165H possibly damaging Het
Wwp1 T C 4: 19,650,360 T269A probably benign Het
Other mutations in Olfr381
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02867:Olfr381 APN 11 73485991 missense probably damaging 1.00
IGL03202:Olfr381 APN 11 73486525 nonsense probably null
R0207:Olfr381 UTSW 11 73486575 missense probably benign 0.00
R0539:Olfr381 UTSW 11 73486063 missense probably benign 0.22
R1469:Olfr381 UTSW 11 73486323 missense possibly damaging 0.81
R1469:Olfr381 UTSW 11 73486323 missense possibly damaging 0.81
R1835:Olfr381 UTSW 11 73486374 missense probably benign 0.08
R2095:Olfr381 UTSW 11 73486594 missense probably damaging 1.00
R3612:Olfr381 UTSW 11 73485940 missense probably benign 0.23
R3983:Olfr381 UTSW 11 73486135 missense possibly damaging 0.84
R4959:Olfr381 UTSW 11 73486067 nonsense probably null
R4983:Olfr381 UTSW 11 73486797 missense probably benign 0.04
R5297:Olfr381 UTSW 11 73486389 missense probably damaging 0.99
R5447:Olfr381 UTSW 11 73486176 missense probably benign 0.01
R5569:Olfr381 UTSW 11 73486692 missense probably damaging 0.97
R5580:Olfr381 UTSW 11 73486210 missense probably benign
R5711:Olfr381 UTSW 11 73486182 missense probably damaging 1.00
R5810:Olfr381 UTSW 11 73486095 nonsense probably null
R6974:Olfr381 UTSW 11 73486473 missense probably benign 0.00
Posted On2011-07-12