Incidental Mutation 'IGL00657:Mettl15'
ID 11968
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl15
Ensembl Gene ENSMUSG00000057234
Gene Name methyltransferase like 15
Synonyms 0610027B03Rik, Mett5d1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # IGL00657
Quality Score
Status
Chromosome 2
Chromosomal Location 108922642-109111093 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108923552 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 290 (I290T)
Ref Sequence ENSEMBL: ENSMUSP00000080337 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081631]
AlphaFold Q9DCL4
Predicted Effect probably damaging
Transcript: ENSMUST00000081631
AA Change: I290T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080337
Gene: ENSMUSG00000057234
AA Change: I290T

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 406 1.5e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147376
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 13 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cntnap2 A G 6: 46,965,721 (GRCm39) D844G probably damaging Het
Krt7 A G 15: 101,324,966 (GRCm39) probably benign Het
Lrig2 T C 3: 104,374,487 (GRCm39) E556G probably damaging Het
Mysm1 T C 4: 94,848,602 (GRCm39) E477G probably benign Het
Nasp T C 4: 116,461,416 (GRCm39) Y234C probably damaging Het
Nipal2 A G 15: 34,600,224 (GRCm39) Y198H probably damaging Het
Nup153 T A 13: 46,834,626 (GRCm39) probably benign Het
Prdm1 A G 10: 44,317,888 (GRCm39) S327P probably damaging Het
Rhobtb1 C A 10: 69,106,051 (GRCm39) D267E probably damaging Het
Sec31a G A 5: 100,551,876 (GRCm39) Q166* probably null Het
Sphkap A G 1: 83,254,096 (GRCm39) C931R probably damaging Het
Sytl2 A G 7: 90,050,618 (GRCm39) R695G probably benign Het
Usp31 A G 7: 121,247,454 (GRCm39) S1330P probably benign Het
Other mutations in Mettl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Mettl15 APN 2 108,923,521 (GRCm39) nonsense probably null
IGL02684:Mettl15 APN 2 108,961,925 (GRCm39) missense probably damaging 0.97
IGL03367:Mettl15 APN 2 108,961,916 (GRCm39) missense probably benign 0.10
R1433:Mettl15 UTSW 2 108,923,266 (GRCm39) missense probably benign 0.00
R1538:Mettl15 UTSW 2 108,962,010 (GRCm39) critical splice acceptor site probably null
R3890:Mettl15 UTSW 2 109,021,924 (GRCm39) missense probably benign 0.03
R5464:Mettl15 UTSW 2 109,021,967 (GRCm39) missense probably benign 0.00
R6609:Mettl15 UTSW 2 108,967,687 (GRCm39) missense probably null 1.00
R7619:Mettl15 UTSW 2 108,923,220 (GRCm39) nonsense probably null
R7737:Mettl15 UTSW 2 108,967,723 (GRCm39) missense probably damaging 0.99
R8914:Mettl15 UTSW 2 108,967,625 (GRCm39) intron probably benign
R9121:Mettl15 UTSW 2 109,104,948 (GRCm39) missense
R9159:Mettl15 UTSW 2 108,923,444 (GRCm39) missense probably damaging 1.00
R9192:Mettl15 UTSW 2 109,104,810 (GRCm39) nonsense probably null
R9364:Mettl15 UTSW 2 108,961,960 (GRCm39) missense probably benign 0.06
R9566:Mettl15 UTSW 2 108,923,592 (GRCm39) missense possibly damaging 0.61
Posted On 2012-12-06