Incidental Mutation 'IGL00657:Mettl15'
ID |
11968 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Mettl15
|
Ensembl Gene |
ENSMUSG00000057234 |
Gene Name |
methyltransferase like 15 |
Synonyms |
0610027B03Rik, Mett5d1 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.126)
|
Stock # |
IGL00657
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
108922642-109111093 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 108923552 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 290
(I290T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000080337
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081631]
|
AlphaFold |
Q9DCL4 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000081631
AA Change: I290T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000080337 Gene: ENSMUSG00000057234 AA Change: I290T
Domain | Start | End | E-Value | Type |
Pfam:Methyltransf_5
|
69 |
406 |
1.5e-90 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147376
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 13 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Cntnap2 |
A |
G |
6: 46,965,721 (GRCm39) |
D844G |
probably damaging |
Het |
Krt7 |
A |
G |
15: 101,324,966 (GRCm39) |
|
probably benign |
Het |
Lrig2 |
T |
C |
3: 104,374,487 (GRCm39) |
E556G |
probably damaging |
Het |
Mysm1 |
T |
C |
4: 94,848,602 (GRCm39) |
E477G |
probably benign |
Het |
Nasp |
T |
C |
4: 116,461,416 (GRCm39) |
Y234C |
probably damaging |
Het |
Nipal2 |
A |
G |
15: 34,600,224 (GRCm39) |
Y198H |
probably damaging |
Het |
Nup153 |
T |
A |
13: 46,834,626 (GRCm39) |
|
probably benign |
Het |
Prdm1 |
A |
G |
10: 44,317,888 (GRCm39) |
S327P |
probably damaging |
Het |
Rhobtb1 |
C |
A |
10: 69,106,051 (GRCm39) |
D267E |
probably damaging |
Het |
Sec31a |
G |
A |
5: 100,551,876 (GRCm39) |
Q166* |
probably null |
Het |
Sphkap |
A |
G |
1: 83,254,096 (GRCm39) |
C931R |
probably damaging |
Het |
Sytl2 |
A |
G |
7: 90,050,618 (GRCm39) |
R695G |
probably benign |
Het |
Usp31 |
A |
G |
7: 121,247,454 (GRCm39) |
S1330P |
probably benign |
Het |
|
Other mutations in Mettl15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00155:Mettl15
|
APN |
2 |
108,923,521 (GRCm39) |
nonsense |
probably null |
|
IGL02684:Mettl15
|
APN |
2 |
108,961,925 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL03367:Mettl15
|
APN |
2 |
108,961,916 (GRCm39) |
missense |
probably benign |
0.10 |
R1433:Mettl15
|
UTSW |
2 |
108,923,266 (GRCm39) |
missense |
probably benign |
0.00 |
R1538:Mettl15
|
UTSW |
2 |
108,962,010 (GRCm39) |
critical splice acceptor site |
probably null |
|
R3890:Mettl15
|
UTSW |
2 |
109,021,924 (GRCm39) |
missense |
probably benign |
0.03 |
R5464:Mettl15
|
UTSW |
2 |
109,021,967 (GRCm39) |
missense |
probably benign |
0.00 |
R6609:Mettl15
|
UTSW |
2 |
108,967,687 (GRCm39) |
missense |
probably null |
1.00 |
R7619:Mettl15
|
UTSW |
2 |
108,923,220 (GRCm39) |
nonsense |
probably null |
|
R7737:Mettl15
|
UTSW |
2 |
108,967,723 (GRCm39) |
missense |
probably damaging |
0.99 |
R8914:Mettl15
|
UTSW |
2 |
108,967,625 (GRCm39) |
intron |
probably benign |
|
R9121:Mettl15
|
UTSW |
2 |
109,104,948 (GRCm39) |
missense |
|
|
R9159:Mettl15
|
UTSW |
2 |
108,923,444 (GRCm39) |
missense |
probably damaging |
1.00 |
R9192:Mettl15
|
UTSW |
2 |
109,104,810 (GRCm39) |
nonsense |
probably null |
|
R9364:Mettl15
|
UTSW |
2 |
108,961,960 (GRCm39) |
missense |
probably benign |
0.06 |
R9566:Mettl15
|
UTSW |
2 |
108,923,592 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
Posted On |
2012-12-06 |