Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00662:Ncapg'

12284

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ncapg

Ensembl Gene

ENSMUSG00000015880

Gene Name

non-SMC condensin I complex, subunit G

Synonyms

MFT.M05.13, Hcapg, 5730507H05Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.952) question?

Stock #

IGL00662

Quality Score

Status

Chromosome

Chromosomal Location

45827261-45857888 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 45850502 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 703 (S703T)

Ref Sequence

ENSEMBL: ENSMUSP00000112871 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045586] [ENSMUST00000117396] [ENSMUST00000190036]

AlphaFold

E9PWG6

Predicted Effect

probably benign
Transcript: ENSMUST00000045586

SMART Domains

Protein: ENSMUSP00000042677
Gene: ENSMUSG00000015882

Domain	Start	End	E-Value	Type
low complexity region	234	253	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000117396
AA Change: S703T

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000112871
Gene: ENSMUSG00000015880
AA Change: S703T

Domain	Start	End	E-Value	Type
Pfam:Cnd3	557	863	7.4e-87	PFAM
low complexity region	864	874	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134090

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134309

Predicted Effect

probably benign
Transcript: ENSMUST00000190036

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000198274

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atg16l2	T	C	7: 100,939,103 (GRCm39)	N587S	probably benign	Het
Bcar3	C	T	3: 122,306,585 (GRCm39)	A186V	probably benign	Het
Bcr	A	T	10: 75,003,932 (GRCm39)		probably benign	Het
Cd207	A	G	6: 83,652,908 (GRCm39)	I74T	possibly damaging	Het
Cenpn	T	C	8: 117,655,326 (GRCm39)		probably null	Het
Chuk	A	T	19: 44,085,649 (GRCm39)	F228I	possibly damaging	Het
Cmss1	T	C	16: 57,124,092 (GRCm39)	D233G	probably damaging	Het
Copg1	C	T	6: 87,879,352 (GRCm39)	T466I	possibly damaging	Het
Ctsll3	A	G	13: 60,946,756 (GRCm39)	S288P	probably benign	Het
Fat3	T	A	9: 15,907,723 (GRCm39)	I2760F	possibly damaging	Het
Gpi1	A	G	7: 33,915,375 (GRCm39)		probably benign	Het
Il18rap	C	T	1: 40,581,081 (GRCm39)	R318C	probably benign	Het
Kcnk9	A	G	15: 72,417,924 (GRCm39)	S69P	probably benign	Het
Kctd18	T	C	1: 57,995,897 (GRCm39)	T127A	probably damaging	Het
Khk	T	C	5: 31,087,019 (GRCm39)		probably benign	Het
Nup98	T	A	7: 101,844,194 (GRCm39)	N47I	probably damaging	Het
Rad1	A	G	15: 10,490,495 (GRCm39)	N154S	probably benign	Het
Rigi	A	G	4: 40,220,389 (GRCm39)		probably benign	Het
Slc35f5	T	A	1: 125,515,161 (GRCm39)	L438H	probably damaging	Het
Slc7a2	A	G	8: 41,358,659 (GRCm39)	Y334C	possibly damaging	Het
Spata17	T	C	1: 186,849,536 (GRCm39)	N124S	probably benign	Het
Tfap2c	T	C	2: 172,393,438 (GRCm39)	Y118H	probably damaging	Het
Tnpo3	A	T	6: 29,565,845 (GRCm39)	L503*	probably null	Het
Utrn	C	T	10: 12,540,705 (GRCm39)	E1907K	probably damaging	Het
Vav3	T	A	3: 109,435,708 (GRCm39)		probably benign	Het
Vps13a	T	A	19: 16,681,904 (GRCm39)	K1033I	probably damaging	Het
Zfp202	A	G	9: 40,122,339 (GRCm39)	N367S	probably benign	Het

Other mutations in Ncapg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00777:Ncapg	APN	5	45,853,107 (GRCm39)	missense	possibly damaging	0.93
IGL00857:Ncapg	APN	5	45,833,927 (GRCm39)	splice site	probably null
IGL00916:Ncapg	APN	5	45,828,534 (GRCm39)	missense	probably benign	0.37
IGL01293:Ncapg	APN	5	45,839,196 (GRCm39)	missense	probably benign	0.01
IGL01360:Ncapg	APN	5	45,831,727 (GRCm39)	nonsense	probably null
IGL01462:Ncapg	APN	5	45,828,477 (GRCm39)	missense	probably benign	0.02
IGL01527:Ncapg	APN	5	45,829,726 (GRCm39)	missense	possibly damaging	0.71
IGL01732:Ncapg	APN	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
IGL01788:Ncapg	APN	5	45,828,423 (GRCm39)	missense	probably damaging	0.97
IGL01871:Ncapg	APN	5	45,845,923 (GRCm39)	missense	probably benign	0.09
IGL03106:Ncapg	APN	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
IGL03124:Ncapg	APN	5	45,828,551 (GRCm39)	missense	probably benign
R0086:Ncapg	UTSW	5	45,834,086 (GRCm39)	splice site	probably null
R0109:Ncapg	UTSW	5	45,851,090 (GRCm39)	splice site	probably null
R0110:Ncapg	UTSW	5	45,850,489 (GRCm39)	unclassified	probably benign
R0377:Ncapg	UTSW	5	45,851,159 (GRCm39)	missense	probably benign
R0432:Ncapg	UTSW	5	45,829,770 (GRCm39)	missense	probably damaging	0.99
R0637:Ncapg	UTSW	5	45,844,666 (GRCm39)	missense	probably damaging	1.00
R0835:Ncapg	UTSW	5	45,838,790 (GRCm39)	missense	probably damaging	0.96
R0894:Ncapg	UTSW	5	45,837,236 (GRCm39)	missense	probably null	0.24
R1069:Ncapg	UTSW	5	45,833,272 (GRCm39)	intron	probably benign
R1216:Ncapg	UTSW	5	45,857,261 (GRCm39)	missense	possibly damaging	0.68
R1967:Ncapg	UTSW	5	45,857,252 (GRCm39)	missense	probably damaging	0.99
R2396:Ncapg	UTSW	5	45,835,715 (GRCm39)	missense	probably benign	0.00
R3157:Ncapg	UTSW	5	45,833,400 (GRCm39)	missense	probably benign
R3735:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3736:Ncapg	UTSW	5	45,853,469 (GRCm39)	missense	probably benign	0.00
R3887:Ncapg	UTSW	5	45,831,705 (GRCm39)	missense	probably benign
R4371:Ncapg	UTSW	5	45,835,797 (GRCm39)	missense	probably benign
R4545:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4546:Ncapg	UTSW	5	45,828,554 (GRCm39)	missense	probably damaging	1.00
R4558:Ncapg	UTSW	5	45,833,986 (GRCm39)	missense	probably benign	0.00
R4615:Ncapg	UTSW	5	45,844,741 (GRCm39)	missense	probably benign	0.00
R4938:Ncapg	UTSW	5	45,828,551 (GRCm39)	missense	probably benign
R5839:Ncapg	UTSW	5	45,829,620 (GRCm39)	missense	probably damaging	0.99
R5871:Ncapg	UTSW	5	45,853,039 (GRCm39)	missense	probably damaging	1.00
R6086:Ncapg	UTSW	5	45,850,578 (GRCm39)	missense	probably damaging	1.00
R6418:Ncapg	UTSW	5	45,839,158 (GRCm39)	missense	probably damaging	1.00
R6617:Ncapg	UTSW	5	45,827,474 (GRCm39)	missense	probably benign	0.03
R7145:Ncapg	UTSW	5	45,827,372 (GRCm39)	missense	possibly damaging	0.82
R7408:Ncapg	UTSW	5	45,853,135 (GRCm39)	missense	probably benign	0.00
R7443:Ncapg	UTSW	5	45,829,652 (GRCm39)	missense	probably benign	0.31
R7463:Ncapg	UTSW	5	45,851,434 (GRCm39)	splice site	probably null
R7509:Ncapg	UTSW	5	45,853,450 (GRCm39)	missense	probably benign	0.01
R7687:Ncapg	UTSW	5	45,857,227 (GRCm39)	missense	probably benign	0.03
R7919:Ncapg	UTSW	5	45,853,390 (GRCm39)	missense	probably benign	0.00
R8022:Ncapg	UTSW	5	45,839,136 (GRCm39)	missense	probably damaging	1.00
R8177:Ncapg	UTSW	5	45,851,095 (GRCm39)	missense	probably benign	0.00
R8261:Ncapg	UTSW	5	45,844,730 (GRCm39)	missense	possibly damaging	0.90
R8263:Ncapg	UTSW	5	45,849,134 (GRCm39)	missense	probably benign	0.44
R8324:Ncapg	UTSW	5	45,853,010 (GRCm39)	missense	probably damaging	1.00
R8333:Ncapg	UTSW	5	45,831,805 (GRCm39)	missense	probably damaging	0.96
R8742:Ncapg	UTSW	5	45,851,216 (GRCm39)	missense	probably damaging	1.00
R9026:Ncapg	UTSW	5	45,853,115 (GRCm39)	missense	probably benign	0.00
R9051:Ncapg	UTSW	5	45,853,140 (GRCm39)	missense	probably damaging	1.00
R9076:Ncapg	UTSW	5	45,833,983 (GRCm39)	missense	probably benign
R9122:Ncapg	UTSW	5	45,846,015 (GRCm39)	missense	possibly damaging	0.95
R9751:Ncapg	UTSW	5	45,851,195 (GRCm39)	missense	probably damaging	1.00
R9776:Ncapg	UTSW	5	45,829,834 (GRCm39)	missense	probably damaging	0.96
RF019:Ncapg	UTSW	5	45,856,198 (GRCm39)	missense	probably benign	0.00
Z1088:Ncapg	UTSW	5	45,837,222 (GRCm39)	missense	probably damaging	1.00
Z1177:Ncapg	UTSW	5	45,829,844 (GRCm39)	critical splice donor site	probably null

Posted On

2012-12-06