Incidental Mutation 'IGL00847:Lypd10'
| ID |
12491 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lypd10
|
| Ensembl Gene |
ENSMUSG00000045587 |
| Gene Name |
Ly6/PLAUR domain containing 10 |
| Synonyms |
BC049730 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
IGL00847
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
24408667-24413960 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 24413673 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 230
(T230A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000053275
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000051714]
[ENSMUST00000205376]
[ENSMUST00000206826]
|
| AlphaFold |
Q810N3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000051714
AA Change: T230A
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000053275
Gene: ENSMUSG00000045587
AA Change: T230A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:UPAR_LY6
|
141 |
219 |
3.5e-12 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205376
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206826
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim1 |
T |
C |
19: 57,140,722 (GRCm39) |
E142G |
possibly damaging |
Het |
| Arid4a |
C |
T |
12: 71,122,492 (GRCm39) |
P958S |
probably damaging |
Het |
| Cct5 |
T |
C |
15: 31,591,073 (GRCm39) |
|
probably benign |
Het |
| Cntnap4 |
C |
T |
8: 113,494,251 (GRCm39) |
|
probably benign |
Het |
| Col4a3 |
C |
T |
1: 82,695,590 (GRCm39) |
L1597F |
probably damaging |
Het |
| Gla |
C |
A |
X: 133,495,947 (GRCm39) |
V179L |
probably benign |
Het |
| Gm20422 |
A |
T |
8: 70,195,642 (GRCm39) |
C212* |
probably null |
Het |
| Hace1 |
T |
A |
10: 45,548,453 (GRCm39) |
Y14* |
probably null |
Het |
| Hcfc2 |
T |
A |
10: 82,577,112 (GRCm39) |
|
probably null |
Het |
| Helz2 |
T |
C |
2: 180,874,038 (GRCm39) |
D2152G |
possibly damaging |
Het |
| Mcm8 |
T |
G |
2: 132,661,594 (GRCm39) |
L74V |
probably benign |
Het |
| Myo18b |
A |
G |
5: 112,978,255 (GRCm39) |
|
probably benign |
Het |
| Ptprg |
A |
T |
14: 12,215,265 (GRCm38) |
N1084I |
probably damaging |
Het |
| Rad21l |
C |
A |
2: 151,502,635 (GRCm39) |
A192S |
probably benign |
Het |
| Scn2a |
A |
G |
2: 65,501,078 (GRCm39) |
D80G |
probably damaging |
Het |
| Serpinb3c |
A |
G |
1: 107,203,990 (GRCm39) |
|
probably null |
Het |
| Sgip1 |
A |
G |
4: 102,786,118 (GRCm39) |
|
probably benign |
Het |
| Slc25a41 |
G |
T |
17: 57,341,957 (GRCm39) |
|
probably null |
Het |
| Snx14 |
C |
A |
9: 88,302,382 (GRCm39) |
R140S |
probably damaging |
Het |
| Svs6 |
A |
C |
2: 164,159,507 (GRCm39) |
K90T |
possibly damaging |
Het |
| Tlcd1 |
T |
A |
11: 78,070,914 (GRCm39) |
Y168N |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,811,978 (GRCm39) |
I3312T |
probably benign |
Het |
| Zfp11 |
A |
G |
5: 129,734,978 (GRCm39) |
V161A |
probably benign |
Het |
|
| Other mutations in Lypd10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01353:Lypd10
|
APN |
7 |
24,413,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01603:Lypd10
|
APN |
7 |
24,411,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03084:Lypd10
|
APN |
7 |
24,413,605 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0453:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0657:Lypd10
|
UTSW |
7 |
24,412,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0946:Lypd10
|
UTSW |
7 |
24,413,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1076:Lypd10
|
UTSW |
7 |
24,413,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1081:Lypd10
|
UTSW |
7 |
24,412,967 (GRCm39) |
splice site |
probably null |
|
|
R1926:Lypd10
|
UTSW |
7 |
24,413,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2571:Lypd10
|
UTSW |
7 |
24,412,819 (GRCm39) |
missense |
probably benign |
0.27 |
|
R3014:Lypd10
|
UTSW |
7 |
24,412,821 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3832:Lypd10
|
UTSW |
7 |
24,413,712 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4197:Lypd10
|
UTSW |
7 |
24,413,119 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4705:Lypd10
|
UTSW |
7 |
24,412,934 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5609:Lypd10
|
UTSW |
7 |
24,413,711 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6166:Lypd10
|
UTSW |
7 |
24,413,644 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6385:Lypd10
|
UTSW |
7 |
24,413,535 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7477:Lypd10
|
UTSW |
7 |
24,413,673 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8022:Lypd10
|
UTSW |
7 |
24,413,599 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8169:Lypd10
|
UTSW |
7 |
24,412,000 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8695:Lypd10
|
UTSW |
7 |
24,413,203 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9129:Lypd10
|
UTSW |
7 |
24,413,170 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2012-12-06 |
Incidental Mutation