Incidental Mutation 'IGL00835:Crlf3'
ID12551
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crlf3
Ensembl Gene ENSMUSG00000017561
Gene Namecytokine receptor-like factor 3
SynonymsCreme9, cytor4
Accession Numbers

Genbank: NM_018776; MGI: 1860086

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00835
Quality Score
Status
Chromosome11
Chromosomal Location80046493-80080991 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 80047675 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 379 (T379A)
Ref Sequence ENSEMBL: ENSMUSP00000060028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061283] [ENSMUST00000103233] [ENSMUST00000177825] [ENSMUST00000178893]
Predicted Effect probably benign
Transcript: ENSMUST00000061283
AA Change: T379A

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000060028
Gene: ENSMUSG00000017561
AA Change: T379A

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect unknown
Transcript: ENSMUST00000103233
AA Change: H341R
SMART Domains Protein: ENSMUSP00000099523
Gene: ENSMUSG00000017561
AA Change: H341R

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177825
SMART Domains Protein: ENSMUSP00000136473
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000178893
SMART Domains Protein: ENSMUSP00000137371
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 39 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted, other(2) Gene trapped(37)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,302,733 D1023G probably damaging Het
Agbl3 A G 6: 34,799,732 D391G probably damaging Het
Aggf1 C A 13: 95,362,477 V450F probably damaging Het
Alms1 A G 6: 85,622,134 Y1314C probably damaging Het
Arfgef3 A G 10: 18,661,358 F192L probably benign Het
Arnt A G 3: 95,490,340 D541G probably damaging Het
AU040320 A G 4: 126,757,071 probably null Het
Cep290 A T 10: 100,563,380 R2255* probably null Het
Creb3l4 T A 3: 90,241,987 H138L possibly damaging Het
Crispld2 G A 8: 120,010,648 R46H probably damaging Het
Ctsb T A 14: 63,135,650 D85E probably damaging Het
Etv2 A T 7: 30,633,667 D325E probably benign Het
Fggy T A 4: 95,837,628 I335N possibly damaging Het
Fkbp1b C T 12: 4,833,726 G90S probably damaging Het
Glra3 A G 8: 55,940,977 probably benign Het
Gpatch8 C A 11: 102,478,549 A1388S probably damaging Het
Grin2b T A 6: 135,733,570 S993C probably damaging Het
Gsg1 A T 6: 135,244,092 M103K possibly damaging Het
Il12rb2 A T 6: 67,360,567 V110D probably damaging Het
Kat8 A G 7: 127,920,504 D174G probably damaging Het
Krt82 A T 15: 101,543,378 I334N probably damaging Het
Lrrfip1 C T 1: 91,115,418 T515I possibly damaging Het
Lrrtm2 T A 18: 35,214,239 L3F probably benign Het
Man1c1 T A 4: 134,564,532 Q575L probably damaging Het
Panx1 A G 9: 15,007,844 S240P probably damaging Het
Phldb2 G A 16: 45,751,456 T1191I probably damaging Het
Plb1 G A 5: 32,364,172 E1456K unknown Het
Prtn3 A G 10: 79,881,052 T84A probably benign Het
R3hdm1 T C 1: 128,235,632 probably benign Het
Sirpa G A 2: 129,609,183 C121Y probably damaging Het
Slc9a3 C A 13: 74,160,302 H475N probably benign Het
Smgc A T 15: 91,844,420 D121V probably damaging Het
Spata16 A T 3: 26,924,262 E459V probably damaging Het
Sult2a4 T A 7: 13,909,789 E284D probably benign Het
Tbc1d32 A G 10: 56,089,846 probably benign Het
Thsd7a A C 6: 12,554,934 V317G probably damaging Het
Trh T C 6: 92,242,789 E182G probably benign Het
Tsc1 A G 2: 28,672,466 D368G possibly damaging Het
Ttc39d T G 17: 80,216,526 C205G probably damaging Het
Unc79 T G 12: 103,141,890 probably benign Het
Vps13d A T 4: 145,160,652 D724E probably damaging Het
Zc3h14 T A 12: 98,747,524 probably null Het
Zfp507 G T 7: 35,776,038 H917N probably damaging Het
Other mutations in Crlf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00690:Crlf3 APN 11 80059337 missense probably damaging 1.00
IGL01520:Crlf3 APN 11 80060146 missense probably benign 0.01
IGL01998:Crlf3 APN 11 80058019 unclassified probably benign
IGL02622:Crlf3 APN 11 80059324 missense probably damaging 1.00
IGL02748:Crlf3 APN 11 80059319 missense probably damaging 0.98
R0064:Crlf3 UTSW 11 80057902 missense possibly damaging 0.81
R0064:Crlf3 UTSW 11 80057902 missense possibly damaging 0.81
R0076:Crlf3 UTSW 11 80056601 unclassified probably benign
R0583:Crlf3 UTSW 11 80059281 missense probably damaging 0.99
R1753:Crlf3 UTSW 11 80057872 missense probably damaging 1.00
R2125:Crlf3 UTSW 11 80059255 missense probably benign 0.21
R2571:Crlf3 UTSW 11 80047513 missense probably benign 0.11
R5894:Crlf3 UTSW 11 80057852 missense probably damaging 1.00
R6086:Crlf3 UTSW 11 80048610 missense possibly damaging 0.81
X0064:Crlf3 UTSW 11 80064187 splice site probably null
Posted On2012-12-06