Incidental Mutation 'IGL00323:Or4f14'
ID 12843
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or4f14
Ensembl Gene ENSMUSG00000096566
Gene Name olfactory receptor family 4 subfamily F member 14
Synonyms Olfr1306, GA_x6K02T2Q125-72954873-72953935, MOR245-15
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # IGL00323
Quality Score
Status
Chromosome 2
Chromosomal Location 111742335-111743273 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111742381 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 298 (M298K)
Ref Sequence ENSEMBL: ENSMUSP00000151142 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099607] [ENSMUST00000214844]
AlphaFold A2BFL7
Predicted Effect possibly damaging
Transcript: ENSMUST00000099607
AA Change: M298K

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097202
Gene: ENSMUSG00000096566
AA Change: M298K

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 4.7e-43 PFAM
Pfam:7tm_1 41 287 9.7e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214844
AA Change: M298K

PolyPhen 2 Score 0.950 (Sensitivity: 0.79; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap5m1 T C 14: 49,311,247 (GRCm39) Y106H probably damaging Het
Atrnl1 C A 19: 57,680,249 (GRCm39) N716K probably benign Het
Ccnq A G 11: 78,641,782 (GRCm39) V236A probably benign Het
Cdk13 A T 13: 17,895,683 (GRCm39) N1075K possibly damaging Het
Daam1 G A 12: 72,005,517 (GRCm39) probably benign Het
Exd2 T C 12: 80,522,940 (GRCm39) V133A probably damaging Het
Glrb T C 3: 80,769,262 (GRCm39) D155G probably damaging Het
Gm13941 T A 2: 110,935,198 (GRCm39) M11L unknown Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Inpp5d G T 1: 87,611,537 (GRCm39) V329F probably benign Het
Lilrb4b A T 10: 51,357,347 (GRCm39) D61V probably benign Het
Malt1 T A 18: 65,582,034 (GRCm39) C299* probably null Het
Or10j27 G A 1: 172,957,978 (GRCm39) Q269* probably null Het
Pigk C A 3: 152,453,269 (GRCm39) S282* probably null Het
Pik3r1 T A 13: 101,827,044 (GRCm39) M1L probably benign Het
Pnpla1 A G 17: 29,096,416 (GRCm39) Y165C probably damaging Het
Rfx7 A G 9: 72,524,702 (GRCm39) N631D probably damaging Het
Rp1 T A 1: 4,416,969 (GRCm39) D1381V probably damaging Het
Rrp8 T C 7: 105,382,223 (GRCm39) probably benign Het
Scn4a A T 11: 106,210,745 (GRCm39) D1757E probably benign Het
Sec62 T C 3: 30,864,591 (GRCm39) probably benign Het
Smarca5 G A 8: 81,440,670 (GRCm39) T598M probably benign Het
Sptbn5 T C 2: 119,884,948 (GRCm39) probably benign Het
Srcap T C 7: 127,141,885 (GRCm39) probably benign Het
Stab1 T A 14: 30,861,263 (GRCm39) E71D probably benign Het
Trhde A T 10: 114,322,652 (GRCm39) S716R possibly damaging Het
Ttn T C 2: 76,726,859 (GRCm39) probably benign Het
Wscd2 A C 5: 113,689,236 (GRCm39) T81P possibly damaging Het
Zfp335 G A 2: 164,734,302 (GRCm39) T1295I probably damaging Het
Other mutations in Or4f14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Or4f14 APN 2 111,742,652 (GRCm39) missense probably benign 0.34
IGL01893:Or4f14 APN 2 111,742,589 (GRCm39) missense possibly damaging 0.65
IGL02433:Or4f14 APN 2 111,742,762 (GRCm39) missense probably damaging 1.00
IGL03302:Or4f14 APN 2 111,743,167 (GRCm39) missense possibly damaging 0.61
R0544:Or4f14 UTSW 2 111,742,905 (GRCm39) nonsense probably null
R0674:Or4f14 UTSW 2 111,743,018 (GRCm39) missense probably benign 0.41
R1118:Or4f14 UTSW 2 111,743,222 (GRCm39) missense probably benign 0.02
R1764:Or4f14 UTSW 2 111,742,526 (GRCm39) missense possibly damaging 0.93
R2915:Or4f14 UTSW 2 111,743,064 (GRCm39) missense probably damaging 1.00
R3976:Or4f14 UTSW 2 111,742,951 (GRCm39) missense possibly damaging 0.84
R4855:Or4f14 UTSW 2 111,742,444 (GRCm39) missense probably benign 0.41
R6475:Or4f14 UTSW 2 111,743,204 (GRCm39) nonsense probably null
R6513:Or4f14 UTSW 2 111,743,228 (GRCm39) missense possibly damaging 0.89
R6536:Or4f14 UTSW 2 111,743,119 (GRCm39) missense possibly damaging 0.94
R6748:Or4f14 UTSW 2 111,742,702 (GRCm39) missense possibly damaging 0.47
R6843:Or4f14 UTSW 2 111,743,260 (GRCm39) missense probably damaging 1.00
R7006:Or4f14 UTSW 2 111,742,601 (GRCm39) missense probably benign 0.16
R7169:Or4f14 UTSW 2 111,742,939 (GRCm39) missense possibly damaging 0.95
R7230:Or4f14 UTSW 2 111,742,906 (GRCm39) missense probably damaging 1.00
R7419:Or4f14 UTSW 2 111,742,435 (GRCm39) missense probably damaging 1.00
R7448:Or4f14 UTSW 2 111,742,637 (GRCm39) missense probably benign 0.00
R7753:Or4f14 UTSW 2 111,742,927 (GRCm39) missense probably benign 0.06
R7761:Or4f14 UTSW 2 111,743,222 (GRCm39) missense probably benign 0.02
R8330:Or4f14 UTSW 2 111,742,724 (GRCm39) missense probably benign 0.00
R8497:Or4f14 UTSW 2 111,742,964 (GRCm39) missense possibly damaging 0.82
R8942:Or4f14 UTSW 2 111,743,207 (GRCm39) missense probably benign 0.05
R9603:Or4f14 UTSW 2 111,743,128 (GRCm39) missense possibly damaging 0.69
Posted On 2012-12-06