Incidental Mutation 'IGL00820:Olfr603'
ID12853
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr603
Ensembl Gene ENSMUSG00000059874
Gene Nameolfactory receptor 603
SynonymsMOR32-2, GA_x6K02T2PBJ9-6092550-6092362, MOR32-14_i, GA_x6K02T2PBJ9-6096387-6095449, Olfr604
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.071) question?
Stock #IGL00820
Quality Score
Status
Chromosome7
Chromosomal Location103383062-103386177 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 103383465 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 179 (T179I)
Ref Sequence ENSEMBL: ENSMUSP00000151321 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071844] [ENSMUST00000218246]
Predicted Effect probably damaging
Transcript: ENSMUST00000071844
AA Change: T179I

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000071744
Gene: ENSMUSG00000059874
AA Change: T179I

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 1.7e-120 PFAM
Pfam:7TM_GPCR_Srsx 37 210 1.9e-10 PFAM
Pfam:7tm_1 43 293 5.4e-16 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000218246
AA Change: T179I

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik A T 4: 41,507,178 L206Q probably damaging Het
Abcg3 T A 5: 104,936,012 I631F probably benign Het
Baiap3 T C 17: 25,248,690 D314G probably benign Het
Ccl1 T C 11: 82,178,088 E41G possibly damaging Het
Ephx1 T C 1: 180,999,821 Y89C possibly damaging Het
Fbxw18 G A 9: 109,693,369 T144I probably damaging Het
Galt C T 4: 41,758,570 A357V probably benign Het
Gfra1 T C 19: 58,263,905 probably benign Het
Hivep1 A T 13: 42,183,818 I2458L probably benign Het
Itga8 A G 2: 12,232,892 V339A possibly damaging Het
Klk1b8 T C 7: 43,954,786 I226T probably benign Het
Mfsd6 C T 1: 52,708,306 V467M probably damaging Het
Mrpl16 T C 19: 11,774,413 V179A probably benign Het
Pnpla6 A G 8: 3,532,358 T693A possibly damaging Het
Ptpn2 A C 18: 67,675,792 I318R possibly damaging Het
Slc17a2 A G 13: 23,819,334 H285R probably benign Het
Slit2 G A 5: 47,989,151 E95K possibly damaging Het
Sptb A G 12: 76,632,477 L68P probably damaging Het
Stxbp6 G A 12: 44,861,346 T163I probably damaging Het
Tex15 A G 8: 33,579,006 probably benign Het
Tti1 T C 2: 158,008,968 E117G probably damaging Het
Ube4b T C 4: 149,352,921 probably benign Het
Wipi1 A C 11: 109,583,119 probably benign Het
Zan A T 5: 137,386,364 C5133S unknown Het
Other mutations in Olfr603
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01582:Olfr603 APN 7 103383599 nonsense probably null
IGL01788:Olfr603 APN 7 103383563 missense probably benign 0.00
IGL02837:Olfr603 UTSW 7 103383615 missense probably damaging 1.00
R1807:Olfr603 UTSW 7 103383583 missense probably benign 0.25
R2097:Olfr603 UTSW 7 103383633 missense probably damaging 1.00
R2161:Olfr603 UTSW 7 103383200 missense probably benign 0.01
R4870:Olfr603 UTSW 7 103383633 missense probably damaging 1.00
R5116:Olfr603 UTSW 7 103383864 missense probably benign 0.03
R6263:Olfr603 UTSW 7 103383196 missense possibly damaging 0.88
R6385:Olfr603 UTSW 7 103383897 missense possibly damaging 0.61
Posted On2012-12-06