Incidental Mutation 'IGL00870:Olfr884'
ID12856
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr884
Ensembl Gene ENSMUSG00000095893
Gene Nameolfactory receptor 884
SynonymsMOR162-13, MOR162-9P, Olfr1550-ps1, MOR162-11P, MOR162-11P, GA_x6K02T2PVTD-31726544-31727473
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL00870
Quality Score
Status
Chromosome9
Chromosomal Location38046555-38050137 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 38047740 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 173 (I173F)
Ref Sequence ENSEMBL: ENSMUSP00000138035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077732] [ENSMUST00000181088]
Predicted Effect probably damaging
Transcript: ENSMUST00000077732
AA Change: I173F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000076912
Gene: ENSMUSG00000095893
AA Change: I173F

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 8e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 5.1e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000181088
AA Change: I173F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000138035
Gene: ENSMUSG00000095893
AA Change: I173F

DomainStartEndE-ValueType
low complexity region 14 33 N/A INTRINSIC
Pfam:7TM_GPCR_Srsx 35 300 1.5e-6 PFAM
Pfam:7tm_1 41 288 4.6e-30 PFAM
Pfam:7tm_4 138 281 3.9e-45 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 9,013,698 D4115E probably damaging Het
Asb5 T C 8: 54,583,660 probably null Het
Cpeb3 A T 19: 37,054,295 I569N probably damaging Het
Cpsf7 T C 19: 10,539,650 probably null Het
Dlat A G 9: 50,650,869 L285P probably damaging Het
Dytn T C 1: 63,677,113 probably benign Het
Ears2 A T 7: 122,055,676 L123Q probably damaging Het
Gad2 T C 2: 22,629,971 V212A probably benign Het
Gon4l T C 3: 88,857,185 Y358H probably damaging Het
Gys1 T C 7: 45,448,013 probably null Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Krtap20-2 G A 16: 89,205,987 G25D unknown Het
Lrif1 T C 3: 106,734,641 probably null Het
Naip2 A G 13: 100,152,060 probably benign Het
Oxct1 T A 15: 4,101,818 L396Q probably damaging Het
Pclo A T 5: 14,539,983 R766W unknown Het
Pkhd1 T A 1: 20,571,390 I275F probably damaging Het
Rxfp3 A G 15: 11,036,215 F357S probably damaging Het
Rxfp3 A G 15: 11,036,305 V327A probably damaging Het
Serpinb2 A G 1: 107,523,070 I181V probably damaging Het
Smad5 A G 13: 56,723,667 D25G probably benign Het
Strada A G 11: 106,171,257 L82P probably damaging Het
Tek T A 4: 94,873,081 Y1079* probably null Het
Tenm3 T C 8: 48,417,132 T209A probably benign Het
Tnks1bp1 C T 2: 85,062,236 Q836* probably null Het
Toporsl T C 4: 52,610,172 S22P probably benign Het
Ttc17 T C 2: 94,371,733 probably null Het
Ttc39a A G 4: 109,442,345 probably benign Het
Vangl1 T C 3: 102,189,440 D60G probably damaging Het
Vmn1r13 A T 6: 57,210,113 M86L probably benign Het
Vmn1r220 C T 13: 23,184,477 M16I probably null Het
Other mutations in Olfr884
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Olfr884 APN 9 38047366 missense probably damaging 1.00
IGL02802:Olfr884 UTSW 9 38048049 missense probably damaging 0.99
R0015:Olfr884 UTSW 9 38047667 nonsense probably null
R0142:Olfr884 UTSW 9 38048110 missense probably benign 0.37
R0559:Olfr884 UTSW 9 38047827 missense probably benign 0.16
R0561:Olfr884 UTSW 9 38047827 missense probably benign 0.16
R0715:Olfr884 UTSW 9 38047827 missense probably benign 0.16
R0723:Olfr884 UTSW 9 38047827 missense probably benign 0.16
R0729:Olfr884 UTSW 9 38047827 missense probably benign 0.16
R1350:Olfr884 UTSW 9 38047815 missense probably benign 0.02
R1869:Olfr884 UTSW 9 38048202 unclassified probably null
R3917:Olfr884 UTSW 9 38047545 missense probably damaging 1.00
R4131:Olfr884 UTSW 9 38047874 nonsense probably null
R4764:Olfr884 UTSW 9 38048140 missense probably benign
R5857:Olfr884 UTSW 9 38047753 missense probably benign 0.18
R5976:Olfr884 UTSW 9 38047701 missense possibly damaging 0.80
R6329:Olfr884 UTSW 9 38047825 missense probably benign 0.02
X0052:Olfr884 UTSW 9 38047699 missense possibly damaging 0.53
Posted On2012-12-06