Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00814:Psg23'

13200

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg23

Ensembl Gene

ENSMUSG00000074359

Gene Name

pregnancy-specific beta-1-glycoprotein 23

Synonyms

1620401C02Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00814

Quality Score

Status

Chromosome

Chromosomal Location

18340268-18350426 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 18348608 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 66 (W66*)

Ref Sequence

ENSEMBL: ENSMUSP00000056586 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057810]

AlphaFold

Q9D2U0

Predicted Effect

probably null
Transcript: ENSMUST00000057810
AA Change: W66*

SMART Domains

Protein: ENSMUSP00000056586
Gene: ENSMUSG00000074359
AA Change: W66*

Domain	Start	End	E-Value	Type
IG	39	138	2.03e-4	SMART
IG	159	260	4.16e-1	SMART
IG	276	375	1.25e-4	SMART
IGc2	393	457	4.7e-9	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for this spontaneous mutation display no phenotypic abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cops6	G	T	5: 138,161,640 (GRCm39)	R58L	probably damaging	Het
Elmo1	T	A	13: 20,470,894 (GRCm39)	M262K	probably damaging	Het
Faim	G	A	9: 98,874,218 (GRCm39)	G15R	probably damaging	Het
Gria4	A	T	9: 4,472,202 (GRCm39)	M429K	probably damaging	Het
Hipk2	G	A	6: 38,795,484 (GRCm39)	R262W	probably damaging	Het
Kif23	A	T	9: 61,844,389 (GRCm39)	I143K	possibly damaging	Het
Mbtd1	T	A	11: 93,834,666 (GRCm39)	S615T	possibly damaging	Het
Nlrp9c	C	T	7: 26,084,175 (GRCm39)	S468N	probably benign	Het
Nt5c2	A	T	19: 46,886,087 (GRCm39)	D212E	probably benign	Het
Or52e19	A	T	7: 102,959,014 (GRCm39)	I29L	probably benign	Het
Pck2	T	C	14: 55,785,756 (GRCm39)		probably benign	Het
Pdcd6ip	T	C	9: 113,516,721 (GRCm39)	Q230R	probably damaging	Het
Pomk	T	C	8: 26,473,624 (GRCm39)	T110A	probably benign	Het
Rnf144b	T	C	13: 47,373,964 (GRCm39)		probably benign	Het
Sppl2c	G	A	11: 104,077,805 (GRCm39)	G202S	possibly damaging	Het
Thnsl2	A	C	6: 71,116,867 (GRCm39)	L95R	probably damaging	Het
Ttn	A	G	2: 76,637,511 (GRCm39)	V12248A	probably benign	Het

Other mutations in Psg23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01309:Psg23	APN	7	18,348,465 (GRCm39)	missense	probably damaging	1.00
IGL01736:Psg23	APN	7	18,346,122 (GRCm39)	missense	possibly damaging	0.76
IGL02142:Psg23	APN	7	18,344,345 (GRCm39)	missense	probably benign	0.01
IGL02728:Psg23	APN	7	18,340,853 (GRCm39)	missense	probably benign	0.02
IGL03080:Psg23	APN	7	18,340,910 (GRCm39)	missense	probably damaging	1.00
IGL03130:Psg23	APN	7	18,344,341 (GRCm39)	missense	probably benign	0.25
R0113:Psg23	UTSW	7	18,345,927 (GRCm39)	missense	probably benign	0.31
R0137:Psg23	UTSW	7	18,348,558 (GRCm39)	missense	probably benign	0.00
R0544:Psg23	UTSW	7	18,348,607 (GRCm39)	missense	probably damaging	1.00
R1368:Psg23	UTSW	7	18,348,645 (GRCm39)	missense	probably benign	0.13
R1840:Psg23	UTSW	7	18,344,363 (GRCm39)	missense	possibly damaging	0.67
R1869:Psg23	UTSW	7	18,348,543 (GRCm39)	missense	probably benign	0.09
R1875:Psg23	UTSW	7	18,344,375 (GRCm39)	missense	probably benign	0.10
R2041:Psg23	UTSW	7	18,348,703 (GRCm39)	missense	possibly damaging	0.78
R2096:Psg23	UTSW	7	18,348,668 (GRCm39)	missense	probably damaging	1.00
R3110:Psg23	UTSW	7	18,344,369 (GRCm39)	missense	possibly damaging	0.72
R3112:Psg23	UTSW	7	18,344,369 (GRCm39)	missense	possibly damaging	0.72
R3790:Psg23	UTSW	7	18,346,126 (GRCm39)	missense	probably benign	0.00
R3892:Psg23	UTSW	7	18,345,966 (GRCm39)	missense	probably damaging	1.00
R4074:Psg23	UTSW	7	18,341,043 (GRCm39)	missense	possibly damaging	0.66
R4200:Psg23	UTSW	7	18,345,990 (GRCm39)	missense	probably damaging	1.00
R4865:Psg23	UTSW	7	18,346,039 (GRCm39)	missense	probably benign	0.14
R5337:Psg23	UTSW	7	18,345,997 (GRCm39)	missense	probably benign	0.00
R6016:Psg23	UTSW	7	18,346,112 (GRCm39)	missense	probably benign	0.00
R6951:Psg23	UTSW	7	18,348,636 (GRCm39)	missense	probably damaging	1.00
R7033:Psg23	UTSW	7	18,348,669 (GRCm39)	missense	possibly damaging	0.82
R7212:Psg23	UTSW	7	18,341,064 (GRCm39)	missense	probably benign	0.00
R7427:Psg23	UTSW	7	18,345,908 (GRCm39)	splice site	probably null
R7527:Psg23	UTSW	7	18,348,699 (GRCm39)	missense	probably damaging	1.00
R7814:Psg23	UTSW	7	18,340,839 (GRCm39)	makesense	probably null
R7864:Psg23	UTSW	7	18,344,435 (GRCm39)	missense	possibly damaging	0.87
R7897:Psg23	UTSW	7	18,341,108 (GRCm39)	missense	possibly damaging	0.83
R8155:Psg23	UTSW	7	18,346,179 (GRCm39)	missense	probably damaging	1.00
R8358:Psg23	UTSW	7	18,348,522 (GRCm39)	missense	probably benign	0.00
R9032:Psg23	UTSW	7	18,348,660 (GRCm39)	missense	possibly damaging	0.83
R9085:Psg23	UTSW	7	18,348,660 (GRCm39)	missense	possibly damaging	0.83
R9365:Psg23	UTSW	7	18,344,393 (GRCm39)	missense	probably damaging	1.00
R9577:Psg23	UTSW	7	18,346,067 (GRCm39)	missense	probably benign	0.00
R9688:Psg23	UTSW	7	18,344,547 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06