Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00673:Psg28'

13201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg28

Ensembl Gene

ENSMUSG00000030373

Gene Name

pregnancy-specific beta-1-glycoprotein 28

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

IGL00673

Quality Score

Status

Chromosome

Chromosomal Location

18156461-18165966 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18161816 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 229 (V229A)

Ref Sequence

ENSEMBL: ENSMUSP00000019291 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019291]

AlphaFold

Q4KL66

Predicted Effect

probably damaging
Transcript: ENSMUST00000019291
AA Change: V229A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000019291
Gene: ENSMUSG00000030373
AA Change: V229A

Domain	Start	End	E-Value	Type
IG	40	138	1.84e-2	SMART
IG	157	258	1.67e0	SMART
IG	277	376	1.65e-4	SMART
IGc2	394	458	8.31e-10	SMART

Meta Mutation Damage Score

0.3380

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts7	T	C	9: 90,075,714 (GRCm39)	S1191P	possibly damaging	Het
Alg2	C	T	4: 47,472,329 (GRCm39)	D160N	probably damaging	Het
Cd177	A	T	7: 24,451,442 (GRCm39)	F487Y	possibly damaging	Het
Cdc27	A	G	11: 104,419,261 (GRCm39)	Y224H	probably damaging	Het
Cdhr1	A	G	14: 36,807,485 (GRCm39)	V385A	probably benign	Het
Cep128	G	T	12: 91,200,965 (GRCm39)	H31Q	probably benign	Het
Ehd4	A	G	2: 119,932,701 (GRCm39)	S242P	probably damaging	Het
Esco1	A	G	18: 10,582,078 (GRCm39)	F647L	probably damaging	Het
Itgbl1	C	T	14: 124,083,844 (GRCm39)		probably benign	Het
Kcnj3	G	T	2: 55,485,284 (GRCm39)	D461Y	possibly damaging	Het
Kcnq3	G	A	15: 65,867,120 (GRCm39)	T841M	probably damaging	Het
Kcnt2	T	G	1: 140,523,789 (GRCm39)	N1103K	possibly damaging	Het
Mib1	A	G	18: 10,798,490 (GRCm39)	S784G	probably benign	Het
Miga2	T	G	2: 30,257,729 (GRCm39)	M9R	probably benign	Het
Pals1	C	A	12: 78,876,573 (GRCm39)	R506S	possibly damaging	Het
Prl2a1	T	C	13: 27,992,436 (GRCm39)	S187P	probably damaging	Het
Ptdss2	G	T	7: 140,723,038 (GRCm39)	C84F	probably benign	Het
Recql	T	A	6: 142,322,647 (GRCm39)	N85I	probably null	Het
Tex47	A	T	5: 7,355,211 (GRCm39)	I131F	probably damaging	Het
Tlk1	G	T	2: 70,575,860 (GRCm39)	Q323K	probably damaging	Het

Other mutations in Psg28

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01118:Psg28	APN	7	18,162,017 (GRCm39)	missense	probably damaging	1.00
IGL01606:Psg28	APN	7	18,164,296 (GRCm39)	missense	probably benign	0.01
R0276:Psg28	UTSW	7	18,164,321 (GRCm39)	missense	probably benign	0.00
R0391:Psg28	UTSW	7	18,160,098 (GRCm39)	missense	probably benign	0.02
R0713:Psg28	UTSW	7	18,156,999 (GRCm39)	missense	possibly damaging	0.61
R1454:Psg28	UTSW	7	18,161,889 (GRCm39)	missense	possibly damaging	0.50
R1725:Psg28	UTSW	7	18,161,936 (GRCm39)	missense	possibly damaging	0.67
R2176:Psg28	UTSW	7	18,161,804 (GRCm39)	missense	probably damaging	1.00
R3154:Psg28	UTSW	7	18,160,348 (GRCm39)	missense	possibly damaging	0.91
R4520:Psg28	UTSW	7	18,156,826 (GRCm39)	missense	probably benign	0.00
R5010:Psg28	UTSW	7	18,161,816 (GRCm39)	missense	probably damaging	1.00
R5529:Psg28	UTSW	7	18,164,373 (GRCm39)	missense	probably benign	0.15
R5772:Psg28	UTSW	7	18,164,640 (GRCm39)	missense	probably damaging	1.00
R6039:Psg28	UTSW	7	18,160,107 (GRCm39)	missense	possibly damaging	0.82
R6039:Psg28	UTSW	7	18,160,107 (GRCm39)	missense	possibly damaging	0.82
R6046:Psg28	UTSW	7	18,160,305 (GRCm39)	missense	probably damaging	1.00
R6275:Psg28	UTSW	7	18,164,365 (GRCm39)	missense	probably damaging	1.00
R6586:Psg28	UTSW	7	18,164,469 (GRCm39)	missense	probably damaging	0.99
R6928:Psg28	UTSW	7	18,157,003 (GRCm39)	missense	possibly damaging	0.80
R7197:Psg28	UTSW	7	18,164,509 (GRCm39)	missense	probably damaging	1.00
R7237:Psg28	UTSW	7	18,161,769 (GRCm39)	missense	possibly damaging	0.65
R7859:Psg28	UTSW	7	18,160,149 (GRCm39)	missense	probably damaging	1.00
R7863:Psg28	UTSW	7	18,162,042 (GRCm39)	missense	possibly damaging	0.62
R7993:Psg28	UTSW	7	18,160,401 (GRCm39)	missense	possibly damaging	0.63
R8009:Psg28	UTSW	7	18,156,922 (GRCm39)	missense	probably damaging	0.96
R8115:Psg28	UTSW	7	18,164,311 (GRCm39)	missense	probably benign	0.15
R8247:Psg28	UTSW	7	18,156,864 (GRCm39)	missense	probably benign	0.01
R8984:Psg28	UTSW	7	18,156,981 (GRCm39)	missense	probably damaging	0.97
R9160:Psg28	UTSW	7	18,164,640 (GRCm39)	missense	probably damaging	1.00
R9266:Psg28	UTSW	7	18,161,752 (GRCm39)	missense	probably benign	0.01
R9336:Psg28	UTSW	7	18,156,905 (GRCm39)	missense	possibly damaging	0.67
R9758:Psg28	UTSW	7	18,164,602 (GRCm39)	missense	probably benign	0.18
R9758:Psg28	UTSW	7	18,156,887 (GRCm39)	nonsense	probably null
R9782:Psg28	UTSW	7	18,164,331 (GRCm39)	missense	probably benign	0.00
RF016:Psg28	UTSW	7	18,156,847 (GRCm39)	missense	probably damaging	0.97
X0020:Psg28	UTSW	7	18,161,864 (GRCm39)	missense	possibly damaging	0.95

Posted On

2012-12-06