Incidental Mutation 'IGL00781:Cdk17'
ID 13353
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk17
Ensembl Gene ENSMUSG00000020015
Gene Name cyclin dependent kinase 17
Synonyms Pctk2, 6430598J10Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # IGL00781
Quality Score
Status
Chromosome 10
Chromosomal Location 92996492-93086956 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93068278 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 312 (Y312C)
Ref Sequence ENSEMBL: ENSMUSP00000150873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069965] [ENSMUST00000215286]
AlphaFold Q8K0D0
Predicted Effect probably damaging
Transcript: ENSMUST00000069965
AA Change: Y345C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070355
Gene: ENSMUSG00000020015
AA Change: Y345C

DomainStartEndE-ValueType
S_TKc 192 473 4.67e-97 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215286
AA Change: Y312C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss3 A G 10: 106,801,887 (GRCm39) S489P probably benign Het
Adam8 A T 7: 139,567,158 (GRCm39) N431K probably damaging Het
Add1 A G 5: 34,770,702 (GRCm39) H271R probably damaging Het
Adgrv1 G A 13: 81,726,349 (GRCm39) L559F probably benign Het
Cemip A G 7: 83,596,488 (GRCm39) I1092T possibly damaging Het
Col20a1 G T 2: 180,645,272 (GRCm39) V885F possibly damaging Het
Dcc A G 18: 71,942,266 (GRCm39) S284P probably benign Het
Ercc4 T C 16: 12,943,233 (GRCm39) V284A possibly damaging Het
Fam184b A T 5: 45,712,534 (GRCm39) probably null Het
Fbln7 G A 2: 128,735,771 (GRCm39) R253Q possibly damaging Het
Gfm2 T C 13: 97,285,847 (GRCm39) F112S probably damaging Het
Gxylt1 C T 15: 93,152,273 (GRCm39) R222H probably damaging Het
Madd T C 2: 90,977,273 (GRCm39) I1385V probably benign Het
Pkn3 C A 2: 29,973,402 (GRCm39) probably benign Het
Sppl2a T A 2: 126,761,640 (GRCm39) N288I probably benign Het
St14 A G 9: 31,015,075 (GRCm39) S308P probably damaging Het
Syne2 C A 12: 76,070,836 (GRCm39) P4430T probably benign Het
Taf6l C T 19: 8,751,025 (GRCm39) G43D probably damaging Het
Trim11 T C 11: 58,881,523 (GRCm39) L472P probably benign Het
Usp2 C T 9: 44,000,462 (GRCm39) R284* probably null Het
Other mutations in Cdk17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Cdk17 APN 10 93,062,633 (GRCm39) missense probably damaging 1.00
IGL01622:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01623:Cdk17 APN 10 93,074,824 (GRCm39) unclassified probably benign
IGL01732:Cdk17 APN 10 93,053,907 (GRCm39) missense probably benign 0.01
IGL01768:Cdk17 APN 10 93,044,123 (GRCm39) missense probably damaging 0.99
IGL02942:Cdk17 APN 10 93,074,830 (GRCm39) missense probably benign
IGL03308:Cdk17 APN 10 93,057,506 (GRCm39) critical splice donor site probably null
delude UTSW 10 93,053,823 (GRCm39) splice site probably null
Imagine UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
Magician UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
prestidigitator UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R4436_Cdk17_536 UTSW 10 93,047,758 (GRCm39) splice site probably null
R0039:Cdk17 UTSW 10 93,062,640 (GRCm39) splice site probably benign
R0398:Cdk17 UTSW 10 93,073,702 (GRCm39) missense probably benign 0.01
R0432:Cdk17 UTSW 10 93,073,652 (GRCm39) unclassified probably benign
R0609:Cdk17 UTSW 10 93,052,334 (GRCm39) missense probably benign
R0781:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1110:Cdk17 UTSW 10 93,074,895 (GRCm39) nonsense probably null
R1604:Cdk17 UTSW 10 93,068,360 (GRCm39) missense probably damaging 1.00
R1674:Cdk17 UTSW 10 93,057,492 (GRCm39) missense probably benign 0.21
R1758:Cdk17 UTSW 10 93,044,112 (GRCm39) missense probably damaging 1.00
R1797:Cdk17 UTSW 10 93,044,114 (GRCm39) missense possibly damaging 0.76
R1864:Cdk17 UTSW 10 93,061,967 (GRCm39) missense probably damaging 1.00
R1924:Cdk17 UTSW 10 93,061,979 (GRCm39) missense probably damaging 1.00
R1929:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R2143:Cdk17 UTSW 10 93,053,881 (GRCm39) missense probably damaging 1.00
R2207:Cdk17 UTSW 10 93,064,624 (GRCm39) missense probably damaging 1.00
R2261:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R2262:Cdk17 UTSW 10 93,047,820 (GRCm39) missense possibly damaging 0.90
R3737:Cdk17 UTSW 10 93,057,506 (GRCm39) critical splice donor site probably null
R3883:Cdk17 UTSW 10 93,047,939 (GRCm39) critical splice donor site probably null
R4436:Cdk17 UTSW 10 93,047,758 (GRCm39) splice site probably null
R5372:Cdk17 UTSW 10 93,061,901 (GRCm39) missense probably benign 0.03
R5444:Cdk17 UTSW 10 93,053,823 (GRCm39) splice site probably null
R5488:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5489:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R5815:Cdk17 UTSW 10 93,064,559 (GRCm39) missense probably damaging 1.00
R6164:Cdk17 UTSW 10 93,071,331 (GRCm39) missense probably benign 0.26
R6209:Cdk17 UTSW 10 93,044,093 (GRCm39) missense probably benign 0.05
R6384:Cdk17 UTSW 10 93,047,827 (GRCm39) missense probably damaging 0.99
R6627:Cdk17 UTSW 10 93,068,274 (GRCm39) missense probably damaging 1.00
R6698:Cdk17 UTSW 10 93,064,540 (GRCm39) missense probably damaging 1.00
R7164:Cdk17 UTSW 10 93,068,343 (GRCm39) missense probably benign 0.07
R8096:Cdk17 UTSW 10 93,052,229 (GRCm39) missense probably damaging 0.98
R8118:Cdk17 UTSW 10 93,052,252 (GRCm39) missense possibly damaging 0.46
R8459:Cdk17 UTSW 10 93,068,289 (GRCm39) missense probably damaging 0.99
R8670:Cdk17 UTSW 10 93,061,958 (GRCm39) nonsense probably null
R8722:Cdk17 UTSW 10 93,064,565 (GRCm39) missense probably damaging 1.00
R8829:Cdk17 UTSW 10 93,042,920 (GRCm39) unclassified probably benign
R9077:Cdk17 UTSW 10 93,068,277 (GRCm39) missense probably damaging 1.00
R9488:Cdk17 UTSW 10 93,044,066 (GRCm39) missense probably damaging 0.98
R9789:Cdk17 UTSW 10 93,060,891 (GRCm39) missense probably damaging 0.98
Posted On 2012-12-06