Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00781:Fam184b'

13464

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fam184b

Ensembl Gene

ENSMUSG00000015879

Gene Name

family with sequence similarity 184, member B

Synonyms

9630031F12Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00781

Quality Score

Status

Chromosome

Chromosomal Location

45687047-45796843 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 45712534 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000016023 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000016023]

AlphaFold

Q0KK56

Predicted Effect

probably null
Transcript: ENSMUST00000016023

SMART Domains

Protein: ENSMUSP00000016023
Gene: ENSMUSG00000015879

Domain	Start	End	E-Value	Type
Pfam:FAM184	50	248	7.7e-28	PFAM
coiled coil region	284	337	N/A	INTRINSIC
coiled coil region	387	495	N/A	INTRINSIC
low complexity region	515	525	N/A	INTRINSIC
coiled coil region	575	620	N/A	INTRINSIC
coiled coil region	686	775	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000199642

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele are viable and exhibit no overt phenotypic abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 20 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss3	A	G	10: 106,801,887 (GRCm39)	S489P	probably benign	Het
Adam8	A	T	7: 139,567,158 (GRCm39)	N431K	probably damaging	Het
Add1	A	G	5: 34,770,702 (GRCm39)	H271R	probably damaging	Het
Adgrv1	G	A	13: 81,726,349 (GRCm39)	L559F	probably benign	Het
Cdk17	A	G	10: 93,068,278 (GRCm39)	Y312C	probably damaging	Het
Cemip	A	G	7: 83,596,488 (GRCm39)	I1092T	possibly damaging	Het
Col20a1	G	T	2: 180,645,272 (GRCm39)	V885F	possibly damaging	Het
Dcc	A	G	18: 71,942,266 (GRCm39)	S284P	probably benign	Het
Ercc4	T	C	16: 12,943,233 (GRCm39)	V284A	possibly damaging	Het
Fbln7	G	A	2: 128,735,771 (GRCm39)	R253Q	possibly damaging	Het
Gfm2	T	C	13: 97,285,847 (GRCm39)	F112S	probably damaging	Het
Gxylt1	C	T	15: 93,152,273 (GRCm39)	R222H	probably damaging	Het
Madd	T	C	2: 90,977,273 (GRCm39)	I1385V	probably benign	Het
Pkn3	C	A	2: 29,973,402 (GRCm39)		probably benign	Het
Sppl2a	T	A	2: 126,761,640 (GRCm39)	N288I	probably benign	Het
St14	A	G	9: 31,015,075 (GRCm39)	S308P	probably damaging	Het
Syne2	C	A	12: 76,070,836 (GRCm39)	P4430T	probably benign	Het
Taf6l	C	T	19: 8,751,025 (GRCm39)	G43D	probably damaging	Het
Trim11	T	C	11: 58,881,523 (GRCm39)	L472P	probably benign	Het
Usp2	C	T	9: 44,000,462 (GRCm39)	R284*	probably null	Het

Other mutations in Fam184b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Fam184b	APN	5	45,697,091 (GRCm39)	missense	probably benign	0.17
IGL01636:Fam184b	APN	5	45,741,637 (GRCm39)	missense	probably benign	0.00
IGL02008:Fam184b	APN	5	45,690,165 (GRCm39)	missense	possibly damaging	0.75
IGL02123:Fam184b	APN	5	45,796,493 (GRCm39)	missense	possibly damaging	0.92
IGL02177:Fam184b	APN	5	45,690,157 (GRCm39)	nonsense	probably null
IGL02192:Fam184b	APN	5	45,695,062 (GRCm39)	missense	probably benign	0.00
IGL02478:Fam184b	APN	5	45,695,039 (GRCm39)	missense	probably damaging	0.99
IGL03368:Fam184b	APN	5	45,689,166 (GRCm39)	missense	possibly damaging	0.91
R0003:Fam184b	UTSW	5	45,712,536 (GRCm39)	splice site	probably benign
R0129:Fam184b	UTSW	5	45,690,120 (GRCm39)	missense	probably damaging	1.00
R0420:Fam184b	UTSW	5	45,741,854 (GRCm39)	missense	probably damaging	1.00
R0647:Fam184b	UTSW	5	45,741,932 (GRCm39)	missense	probably benign
R1215:Fam184b	UTSW	5	45,741,520 (GRCm39)	missense	probably damaging	1.00
R1374:Fam184b	UTSW	5	45,712,485 (GRCm39)	missense	probably benign
R1466:Fam184b	UTSW	5	45,737,851 (GRCm39)	splice site	probably benign
R1773:Fam184b	UTSW	5	45,741,676 (GRCm39)	missense	possibly damaging	0.60
R1865:Fam184b	UTSW	5	45,689,231 (GRCm39)	missense	possibly damaging	0.91
R3615:Fam184b	UTSW	5	45,740,157 (GRCm39)	missense	possibly damaging	0.56
R3616:Fam184b	UTSW	5	45,740,157 (GRCm39)	missense	possibly damaging	0.56
R4180:Fam184b	UTSW	5	45,697,106 (GRCm39)	missense	probably benign	0.00
R4375:Fam184b	UTSW	5	45,699,685 (GRCm39)	missense	probably benign
R4674:Fam184b	UTSW	5	45,740,230 (GRCm39)	nonsense	probably null
R4942:Fam184b	UTSW	5	45,730,649 (GRCm39)	missense	probably damaging	0.97
R5021:Fam184b	UTSW	5	45,730,604 (GRCm39)	missense	probably benign	0.01
R5450:Fam184b	UTSW	5	45,697,143 (GRCm39)	missense	probably benign
R5731:Fam184b	UTSW	5	45,710,471 (GRCm39)	missense	probably benign	0.00
R5858:Fam184b	UTSW	5	45,796,461 (GRCm39)	missense	probably damaging	0.99
R6032:Fam184b	UTSW	5	45,740,238 (GRCm39)	missense	probably benign	0.01
R6032:Fam184b	UTSW	5	45,740,238 (GRCm39)	missense	probably benign	0.01
R6060:Fam184b	UTSW	5	45,710,489 (GRCm39)	missense	probably damaging	0.99
R6088:Fam184b	UTSW	5	45,741,354 (GRCm39)	missense	probably damaging	1.00
R6416:Fam184b	UTSW	5	45,694,995 (GRCm39)	missense	probably benign	0.04
R6932:Fam184b	UTSW	5	45,690,243 (GRCm39)	splice site	probably null
R6956:Fam184b	UTSW	5	45,688,099 (GRCm39)	missense	probably damaging	0.97
R6965:Fam184b	UTSW	5	45,712,477 (GRCm39)	missense	probably benign
R7229:Fam184b	UTSW	5	45,741,517 (GRCm39)	missense	probably damaging	1.00
R7303:Fam184b	UTSW	5	45,699,568 (GRCm39)	critical splice donor site	probably null
R7429:Fam184b	UTSW	5	45,698,230 (GRCm39)	missense	probably benign
R7522:Fam184b	UTSW	5	45,688,093 (GRCm39)	missense	probably damaging	1.00
R7541:Fam184b	UTSW	5	45,699,574 (GRCm39)	missense	probably damaging	0.99
R7942:Fam184b	UTSW	5	45,741,595 (GRCm39)	missense	probably benign	0.16
R8172:Fam184b	UTSW	5	45,741,709 (GRCm39)	missense	possibly damaging	0.86
R9470:Fam184b	UTSW	5	45,741,854 (GRCm39)	missense	probably damaging	1.00
R9649:Fam184b	UTSW	5	45,796,484 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06