Incidental Mutation 'IGL00717:Gpr65'
| ID |
13518 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr65
|
| Ensembl Gene |
ENSMUSG00000021886 |
| Gene Name |
G-protein coupled receptor 65 |
| Synonyms |
TDAG8, Dig1, Gpcr25 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL00717
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
12 |
| Chromosomal Location |
98234894-98242903 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 98242314 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 322
(I322M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000074581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075072]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075072
AA Change: I322M
PolyPhen 2
Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000074581
Gene: ENSMUSG00000021886
AA Change: I322M
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_1
|
33 |
290 |
1.9e-41 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218404
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219320
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 12 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Casp12 |
A |
G |
9: 5,352,702 (GRCm39) |
T175A |
probably damaging |
Het |
| Daw1 |
A |
T |
1: 83,175,900 (GRCm39) |
I213F |
probably benign |
Het |
| Dmc1 |
A |
G |
15: 79,480,481 (GRCm39) |
M97T |
probably benign |
Het |
| Fanci |
C |
T |
7: 79,062,448 (GRCm39) |
L353F |
probably damaging |
Het |
| Herc1 |
A |
G |
9: 66,392,284 (GRCm39) |
D4064G |
probably damaging |
Het |
| Hipk3 |
G |
T |
2: 104,260,576 (GRCm39) |
T1089K |
possibly damaging |
Het |
| Iigp1c |
A |
G |
18: 60,379,365 (GRCm39) |
E300G |
probably damaging |
Het |
| Mia2 |
A |
G |
12: 59,207,059 (GRCm39) |
|
probably benign |
Het |
| Rnf17 |
A |
G |
14: 56,703,207 (GRCm39) |
T653A |
probably benign |
Het |
| Slc22a8 |
T |
A |
19: 8,587,293 (GRCm39) |
I451K |
probably benign |
Het |
| Trpm5 |
A |
T |
7: 142,627,727 (GRCm39) |
V84E |
probably damaging |
Het |
| Vcam1 |
C |
A |
3: 115,908,120 (GRCm39) |
K647N |
possibly damaging |
Het |
|
| Other mutations in Gpr65 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00435:Gpr65
|
APN |
12 |
98,241,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01643:Gpr65
|
APN |
12 |
98,242,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01942:Gpr65
|
APN |
12 |
98,241,974 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02023:Gpr65
|
APN |
12 |
98,242,127 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02803:Gpr65
|
APN |
12 |
98,241,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Gpr65
|
UTSW |
12 |
98,241,888 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1520:Gpr65
|
UTSW |
12 |
98,241,434 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1771:Gpr65
|
UTSW |
12 |
98,242,259 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1812:Gpr65
|
UTSW |
12 |
98,242,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2261:Gpr65
|
UTSW |
12 |
98,241,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2263:Gpr65
|
UTSW |
12 |
98,241,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5720:Gpr65
|
UTSW |
12 |
98,241,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7458:Gpr65
|
UTSW |
12 |
98,242,324 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Gpr65
|
UTSW |
12 |
98,241,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9376:Gpr65
|
UTSW |
12 |
98,241,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2012-12-06 |
Incidental Mutation