Incidental Mutation 'IGL00664:Ifna4'
| ID |
13548 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Ifna4
|
| Ensembl Gene |
ENSMUSG00000070904 |
| Gene Name |
interferon alpha 4 |
| Synonyms |
Ifa4 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.050)
|
| Stock # |
IGL00664
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
88760098-88760658 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 88760336 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 80
(V80A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092581
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094973]
|
| AlphaFold |
P07351 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094973
AA Change: V80A
PolyPhen 2
Score 0.154 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000092581
Gene: ENSMUSG00000070904
AA Change: V80A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
IFabd
|
59 |
171 |
3.26e-56 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 5 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam34l |
A |
T |
8: 44,079,006 (GRCm39) |
V406E |
probably benign |
Het |
| Bptf |
T |
A |
11: 106,968,491 (GRCm39) |
D1001V |
possibly damaging |
Het |
| Clca3a1 |
G |
A |
3: 144,733,660 (GRCm39) |
T92M |
probably benign |
Het |
| Elac2 |
T |
C |
11: 64,871,476 (GRCm39) |
V129A |
possibly damaging |
Het |
| Fyb2 |
T |
C |
4: 104,872,913 (GRCm39) |
I762T |
probably damaging |
Het |
|
| Other mutations in Ifna4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01781:Ifna4
|
APN |
4 |
88,760,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02259:Ifna4
|
APN |
4 |
88,760,293 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02873:Ifna4
|
APN |
4 |
88,760,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4453001:Ifna4
|
UTSW |
4 |
88,760,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1464:Ifna4
|
UTSW |
4 |
88,760,237 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1464:Ifna4
|
UTSW |
4 |
88,760,237 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Ifna4
|
UTSW |
4 |
88,760,311 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4724:Ifna4
|
UTSW |
4 |
88,760,519 (GRCm39) |
missense |
probably benign |
|
|
R4726:Ifna4
|
UTSW |
4 |
88,760,519 (GRCm39) |
missense |
probably benign |
|
|
R4727:Ifna4
|
UTSW |
4 |
88,760,519 (GRCm39) |
missense |
probably benign |
|
|
R4728:Ifna4
|
UTSW |
4 |
88,760,519 (GRCm39) |
missense |
probably benign |
|
|
R4751:Ifna4
|
UTSW |
4 |
88,760,185 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5885:Ifna4
|
UTSW |
4 |
88,760,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7673:Ifna4
|
UTSW |
4 |
88,760,309 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
| Posted On |
2012-12-06 |
Incidental Mutation