Incidental Mutation 'IGL00551:Limd2'
ID13585
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Limd2
Ensembl Gene ENSMUSG00000040699
Gene NameLIM domain containing 2
Synonyms0610025L06Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL00551
Quality Score
Status
Chromosome11
Chromosomal Location106156256-106160860 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 106159205 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 15 (E15G)
Ref Sequence ENSEMBL: ENSMUSP00000102488 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002044] [ENSMUST00000007444] [ENSMUST00000045923] [ENSMUST00000064545] [ENSMUST00000100326] [ENSMUST00000103072] [ENSMUST00000106875]
Predicted Effect probably benign
Transcript: ENSMUST00000002044
SMART Domains Protein: ENSMUSP00000002044
Gene: ENSMUSG00000020700

DomainStartEndE-ValueType
PB1 44 123 1.04e-18 SMART
S_TKc 362 622 4.23e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000007444
SMART Domains Protein: ENSMUSP00000007444
Gene: ENSMUSG00000069631

DomainStartEndE-ValueType
Pfam:Pkinase 69 379 2.4e-37 PFAM
Pfam:Pkinase_Tyr 70 302 2.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000045923
AA Change: E15G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000045357
Gene: ENSMUSG00000040699
AA Change: E15G

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000064545
AA Change: E15G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000067070
Gene: ENSMUSG00000040699
AA Change: E15G

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000100326
SMART Domains Protein: ENSMUSP00000097900
Gene: ENSMUSG00000075480

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
low complexity region 61 74 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000103072
SMART Domains Protein: ENSMUSP00000099361
Gene: ENSMUSG00000069631

DomainStartEndE-ValueType
Pfam:Pkinase 32 342 2.2e-35 PFAM
Pfam:Pkinase_Tyr 33 266 2.5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106875
AA Change: E15G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000102488
Gene: ENSMUSG00000040699
AA Change: E15G

DomainStartEndE-ValueType
LIM 40 92 3.93e-13 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122989
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138094
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Art2b C T 7: 101,580,569 C41Y probably damaging Het
Btk A G X: 134,573,934 Y42H probably damaging Het
Cacna1e T C 1: 154,403,683 D1720G probably damaging Het
Ccr5 T C 9: 124,124,588 I76T probably damaging Het
Chd3 A G 11: 69,346,629 V1913A probably damaging Het
Dmxl2 A G 9: 54,450,838 Y526H probably damaging Het
Dnah8 A T 17: 30,663,478 K675* probably null Het
Eif2b1 A G 5: 124,576,869 F115L probably damaging Het
Erlin1 T C 19: 44,059,146 D112G probably damaging Het
Fabp12 A G 3: 10,246,055 probably benign Het
Fam47c A G X: 78,738,454 E214G probably damaging Het
Fkbp5 G T 17: 28,401,046 probably benign Het
Hist1h1c C A 13: 23,738,845 probably benign Het
Kidins220 G T 12: 25,038,560 probably benign Het
Mga T A 2: 119,919,814 C696S possibly damaging Het
Naa16 A G 14: 79,355,729 F468L probably damaging Het
Ndufaf1 A G 2: 119,660,469 S37P probably damaging Het
Phrf1 A G 7: 141,258,877 probably benign Het
Prr14 A G 7: 127,474,647 T228A probably benign Het
Rfc1 A T 5: 65,296,009 F265L probably benign Het
Selenos A G 7: 66,087,194 E137G probably benign Het
Tars T C 15: 11,388,221 probably null Het
Tpcn1 A G 5: 120,560,325 I44T probably benign Het
Usp26 A G X: 51,757,305 V31A probably benign Het
Other mutations in Limd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01516:Limd2 APN 11 106159044 missense probably benign
R2088:Limd2 UTSW 11 106158742 missense probably damaging 0.99
R4870:Limd2 UTSW 11 106159389 start codon destroyed probably null 0.36
R6807:Limd2 UTSW 11 106158945 missense probably benign
R6846:Limd2 UTSW 11 106159387 start codon destroyed probably null 0.57
R6998:Limd2 UTSW 11 106158690 missense probably benign 0.11
Posted On2012-12-06