Incidental Mutation 'IGL00539:Mta3'
ID 13622
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mta3
Ensembl Gene ENSMUSG00000055817
Gene Name metastasis associated 3
Synonyms 1110002J22Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.506) question?
Stock # IGL00539
Quality Score
Status
Chromosome 17
Chromosomal Location 84013592-84128945 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 84070412 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 39 (R39Q)
Ref Sequence ENSEMBL: ENSMUSP00000135752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067826] [ENSMUST00000112349] [ENSMUST00000112350] [ENSMUST00000112352] [ENSMUST00000176816] [ENSMUST00000177069]
AlphaFold Q924K8
Predicted Effect probably benign
Transcript: ENSMUST00000067826
AA Change: R190Q

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000068931
Gene: ENSMUSG00000055817
AA Change: R190Q

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 203 3.49e-16 SMART
SANT 266 315 7.94e-8 SMART
ZnF_GATA 371 425 8.33e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112349
AA Change: R191Q

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000107968
Gene: ENSMUSG00000055817
AA Change: R191Q

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 373 427 8.33e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112350
AA Change: R191Q

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000107969
Gene: ENSMUSG00000055817
AA Change: R191Q

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 372 426 8.33e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000112352
AA Change: R191Q

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000107971
Gene: ENSMUSG00000055817
AA Change: R191Q

DomainStartEndE-ValueType
BAH 4 147 2.62e-30 SMART
ELM2 150 204 2.5e-17 SMART
SANT 267 316 7.94e-8 SMART
ZnF_GATA 372 426 8.33e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176816
AA Change: R39Q

PolyPhen 2 Score 0.251 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000135752
Gene: ENSMUSG00000055817
AA Change: R39Q

DomainStartEndE-ValueType
ELM2 1 52 3.23e-11 SMART
SANT 115 164 7.94e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177069
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak C A 19: 8,985,272 (GRCm39) D2185E possibly damaging Het
Camk2b A G 11: 5,922,310 (GRCm39) S560P probably damaging Het
Cdh13 C A 8: 120,039,245 (GRCm39) N562K possibly damaging Het
Cdhr4 A G 9: 107,876,744 (GRCm39) Y771C probably damaging Het
Ermap A G 4: 119,041,114 (GRCm39) S299P probably damaging Het
Fgd3 A G 13: 49,429,119 (GRCm39) probably benign Het
Fpr-rs4 T A 17: 18,242,188 (GRCm39) L65Q probably damaging Het
Hsph1 C T 5: 149,542,254 (GRCm39) R723H possibly damaging Het
Iqcb1 A G 16: 36,678,873 (GRCm39) K396E probably damaging Het
Kif21a T C 15: 90,821,504 (GRCm39) T1424A probably damaging Het
Mpdz T C 4: 81,279,588 (GRCm39) S700G possibly damaging Het
Muc4 A T 16: 32,569,728 (GRCm39) T263S possibly damaging Het
Ncan G A 8: 70,567,921 (GRCm39) P64S probably benign Het
Pisd T C 5: 32,895,756 (GRCm39) I441V probably benign Het
Pla2g4f T C 2: 120,133,219 (GRCm39) H660R possibly damaging Het
Polq A G 16: 36,880,931 (GRCm39) T753A probably damaging Het
Ptchd4 C T 17: 42,627,817 (GRCm39) Q93* probably null Het
Sfpq T C 4: 126,917,481 (GRCm39) V437A possibly damaging Het
Slc18b1 G A 10: 23,700,659 (GRCm39) probably null Het
Taf1c C T 8: 120,328,067 (GRCm39) V277I possibly damaging Het
Tcf20 T A 15: 82,736,957 (GRCm39) Q1498L probably benign Het
Tet1 C A 10: 62,650,276 (GRCm39) C1644F probably damaging Het
Trmt5 T C 12: 73,331,693 (GRCm39) E121G possibly damaging Het
Wapl A G 14: 34,416,965 (GRCm39) D525G probably damaging Het
Ylpm1 A G 12: 85,075,728 (GRCm39) T360A possibly damaging Het
Zfp292 G A 4: 34,808,790 (GRCm39) P1418L probably damaging Het
Other mutations in Mta3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Mta3 APN 17 84,015,861 (GRCm39) missense probably damaging 1.00
IGL00467:Mta3 APN 17 84,063,113 (GRCm39) splice site probably benign
IGL00475:Mta3 APN 17 84,015,861 (GRCm39) missense probably damaging 1.00
IGL01722:Mta3 APN 17 84,063,072 (GRCm39) missense possibly damaging 0.95
IGL03355:Mta3 APN 17 84,107,474 (GRCm39) splice site probably benign
container UTSW 17 84,015,875 (GRCm39) missense probably damaging 1.00
R0440:Mta3 UTSW 17 84,074,016 (GRCm39) missense probably damaging 1.00
R0630:Mta3 UTSW 17 84,022,056 (GRCm39) missense probably damaging 0.98
R1848:Mta3 UTSW 17 84,062,980 (GRCm39) splice site probably benign
R1870:Mta3 UTSW 17 84,089,397 (GRCm39) missense probably damaging 0.98
R2358:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R2373:Mta3 UTSW 17 84,091,730 (GRCm39) nonsense probably null
R2447:Mta3 UTSW 17 84,111,973 (GRCm39) missense probably benign 0.03
R3711:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R3712:Mta3 UTSW 17 84,070,417 (GRCm39) missense probably damaging 0.96
R4107:Mta3 UTSW 17 84,070,343 (GRCm39) missense probably benign 0.00
R4771:Mta3 UTSW 17 84,063,103 (GRCm39) missense probably damaging 0.98
R5259:Mta3 UTSW 17 84,112,003 (GRCm39) missense probably damaging 1.00
R5980:Mta3 UTSW 17 84,015,834 (GRCm39) missense probably damaging 1.00
R6175:Mta3 UTSW 17 84,099,222 (GRCm39) missense probably benign
R6555:Mta3 UTSW 17 84,015,875 (GRCm39) missense probably damaging 1.00
R6909:Mta3 UTSW 17 84,073,980 (GRCm39) missense possibly damaging 0.92
R7170:Mta3 UTSW 17 84,022,091 (GRCm39) missense probably damaging 1.00
R7350:Mta3 UTSW 17 84,015,870 (GRCm39) missense probably damaging 1.00
R7597:Mta3 UTSW 17 84,083,011 (GRCm39) missense probably benign 0.05
R7638:Mta3 UTSW 17 84,107,572 (GRCm39) missense probably benign
R7747:Mta3 UTSW 17 84,099,165 (GRCm39) nonsense probably null
R7894:Mta3 UTSW 17 84,070,363 (GRCm39) missense probably benign 0.01
R8170:Mta3 UTSW 17 84,099,090 (GRCm39) missense probably damaging 1.00
R8799:Mta3 UTSW 17 84,096,369 (GRCm39) missense possibly damaging 0.93
R8944:Mta3 UTSW 17 84,083,146 (GRCm39) missense probably damaging 1.00
R9210:Mta3 UTSW 17 84,015,846 (GRCm39) missense probably damaging 0.99
R9212:Mta3 UTSW 17 84,015,846 (GRCm39) missense probably damaging 0.99
Z1088:Mta3 UTSW 17 84,070,343 (GRCm39) missense probably benign 0.00
Z1177:Mta3 UTSW 17 84,089,397 (GRCm39) missense probably damaging 0.98
Posted On 2012-12-06