Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00547:Oas3'

13659

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas3

Ensembl Gene

ENSMUSG00000032661

Gene Name

2'-5' oligoadenylate synthetase 3

Synonyms

Oasl10, 2'-5' oligoadenylate synthetase-like 10

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL00547

Quality Score

Status

Chromosome

Chromosomal Location

120891163-120915726 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to T at 120915507 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000035588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044833]

AlphaFold

Q8VI93

Predicted Effect

probably benign
Transcript: ENSMUST00000044833

SMART Domains

Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	159	341	6.3e-83	PFAM
Pfam:OAS1_C	610	795	3.1e-78	PFAM
Pfam:NTP_transf_2	831	920	4.5e-11	PFAM
Pfam:OAS1_C	954	1136	9e-85	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000166703

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201006

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts7	C	A	9: 90,076,302 (GRCm39)	Q1345K	possibly damaging	Het
Arhgap40	T	C	2: 158,380,546 (GRCm39)		probably benign	Het
Atp8b4	A	G	2: 126,200,817 (GRCm39)	C784R	probably damaging	Het
Bicral	T	C	17: 47,136,278 (GRCm39)	I311V	probably benign	Het
Cep290	G	A	10: 100,346,570 (GRCm39)	R551H	probably damaging	Het
Chd9	A	T	8: 91,732,426 (GRCm39)	M842L	probably damaging	Het
Cntn6	A	G	6: 104,627,361 (GRCm39)	N65D	probably damaging	Het
Dnah8	C	T	17: 31,034,677 (GRCm39)	Q4199*	probably null	Het
Ercc3	T	C	18: 32,397,598 (GRCm39)		probably benign	Het
Gm454	T	C	5: 138,205,389 (GRCm39)		noncoding transcript	Het
Gm7073	A	T	X: 59,481,748 (GRCm39)	D204E	probably benign	Het
Myo5a	A	G	9: 75,048,735 (GRCm39)	H286R	probably benign	Het
Nelfb	C	A	2: 25,094,300 (GRCm39)	M354I	possibly damaging	Het
Phldb2	A	G	16: 45,645,898 (GRCm39)	S228P	probably benign	Het
Pls3	A	T	X: 74,837,874 (GRCm39)	I429N	probably damaging	Het
Ptprq	C	T	10: 107,554,402 (GRCm39)	V108M	probably damaging	Het
Rlf	A	G	4: 121,027,883 (GRCm39)	S138P	possibly damaging	Het
Rpn2	T	C	2: 157,156,833 (GRCm39)	Y479H	probably damaging	Het
Sdr16c5	A	T	4: 4,012,320 (GRCm39)		probably benign	Het
Slco6c1	A	T	1: 97,015,674 (GRCm39)	N372K	probably benign	Het
Stag2	T	C	X: 41,335,892 (GRCm39)	I563T	probably benign	Het
Vrk1	T	C	12: 106,024,840 (GRCm39)	S239P	probably damaging	Het

Other mutations in Oas3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01095:Oas3	APN	5	120,910,954 (GRCm39)	missense	probably damaging	1.00
IGL01835:Oas3	APN	5	120,904,193 (GRCm39)	nonsense	probably null
IGL02006:Oas3	APN	5	120,907,300 (GRCm39)	missense	probably benign	0.00
IGL02811:Oas3	APN	5	120,902,387 (GRCm39)	missense	unknown
IGL03194:Oas3	APN	5	120,897,018 (GRCm39)	missense	probably damaging	1.00
R0066:Oas3	UTSW	5	120,896,940 (GRCm39)	missense	probably damaging	1.00
R0195:Oas3	UTSW	5	120,894,210 (GRCm39)	missense	probably damaging	1.00
R0196:Oas3	UTSW	5	120,894,210 (GRCm39)	missense	probably damaging	1.00
R0197:Oas3	UTSW	5	120,894,210 (GRCm39)	missense	probably damaging	1.00
R0445:Oas3	UTSW	5	120,894,210 (GRCm39)	missense	probably damaging	1.00
R0523:Oas3	UTSW	5	120,904,209 (GRCm39)	missense	unknown
R0592:Oas3	UTSW	5	120,909,214 (GRCm39)	missense	probably damaging	1.00
R0946:Oas3	UTSW	5	120,907,128 (GRCm39)	missense	unknown
R1354:Oas3	UTSW	5	120,908,065 (GRCm39)	missense	possibly damaging	0.94
R1642:Oas3	UTSW	5	120,915,639 (GRCm39)	missense	possibly damaging	0.90
R1681:Oas3	UTSW	5	120,907,973 (GRCm39)	missense	probably benign	0.22
R1844:Oas3	UTSW	5	120,898,045 (GRCm39)	missense	probably damaging	0.99
R1981:Oas3	UTSW	5	120,899,900 (GRCm39)	splice site	probably benign
R2443:Oas3	UTSW	5	120,915,553 (GRCm39)	missense	probably benign	0.35
R2902:Oas3	UTSW	5	120,896,982 (GRCm39)	missense	probably damaging	1.00
R3034:Oas3	UTSW	5	120,909,121 (GRCm39)	missense	probably damaging	1.00
R4565:Oas3	UTSW	5	120,909,104 (GRCm39)	missense	probably damaging	1.00
R4692:Oas3	UTSW	5	120,907,420 (GRCm39)	missense	probably benign	0.03
R4723:Oas3	UTSW	5	120,904,321 (GRCm39)	missense	unknown
R4812:Oas3	UTSW	5	120,899,212 (GRCm39)	unclassified	probably benign
R5288:Oas3	UTSW	5	120,895,055 (GRCm39)	missense	probably damaging	1.00
R5343:Oas3	UTSW	5	120,894,303 (GRCm39)	missense	possibly damaging	0.70
R5494:Oas3	UTSW	5	120,899,709 (GRCm39)	missense	unknown
R5688:Oas3	UTSW	5	120,896,867 (GRCm39)	missense	probably benign	0.31
R5894:Oas3	UTSW	5	120,895,019 (GRCm39)	missense	probably damaging	1.00
R5921:Oas3	UTSW	5	120,908,046 (GRCm39)	missense	probably damaging	1.00
R6037:Oas3	UTSW	5	120,907,384 (GRCm39)	missense	probably benign	0.41
R6037:Oas3	UTSW	5	120,907,384 (GRCm39)	missense	probably benign	0.41
R6066:Oas3	UTSW	5	120,910,989 (GRCm39)	missense	probably damaging	0.97
R6104:Oas3	UTSW	5	120,899,758 (GRCm39)	missense	unknown
R6134:Oas3	UTSW	5	120,907,113 (GRCm39)	missense	unknown
R6255:Oas3	UTSW	5	120,909,295 (GRCm39)	missense	probably benign	0.04
R6257:Oas3	UTSW	5	120,899,200 (GRCm39)	unclassified	probably benign
R6776:Oas3	UTSW	5	120,896,939 (GRCm39)	missense	probably damaging	1.00
R8022:Oas3	UTSW	5	120,895,031 (GRCm39)	missense	possibly damaging	0.91
R8137:Oas3	UTSW	5	120,915,565 (GRCm39)	missense	probably benign	0.07
R8967:Oas3	UTSW	5	120,896,907 (GRCm39)	missense	probably damaging	0.99
R9124:Oas3	UTSW	5	120,912,170 (GRCm39)	missense	probably damaging	1.00
R9287:Oas3	UTSW	5	120,892,754 (GRCm39)	missense	probably damaging	1.00
R9661:Oas3	UTSW	5	120,904,230 (GRCm39)	missense	unknown
R9745:Oas3	UTSW	5	120,899,284 (GRCm39)	missense	unknown
RF006:Oas3	UTSW	5	120,912,165 (GRCm39)	missense	probably damaging	1.00
X0024:Oas3	UTSW	5	120,899,793 (GRCm39)	missense	unknown

Posted On

2012-12-06