Incidental Mutation 'IGL00331:Sntn'
ID14171
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sntn
Ensembl Gene ENSMUSG00000044772
Gene Namesentan, cilia apical structure protein
SynonymsA430083B19Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.028) question?
Stock #IGL00331
Quality Score
Status
Chromosome14
Chromosomal Location13670876-13683148 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to T at 13679086 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 87 (Q87*)
Ref Sequence ENSEMBL: ENSMUSP00000062092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061045]
Predicted Effect probably null
Transcript: ENSMUST00000061045
AA Change: Q87*
SMART Domains Protein: ENSMUSP00000062092
Gene: ENSMUSG00000044772
AA Change: Q87*

DomainStartEndE-ValueType
low complexity region 19 32 N/A INTRINSIC
SCOP:d1psra_ 53 133 2e-15 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aamp C A 1: 74,281,436 probably benign Het
Adamts19 T A 18: 59,007,325 probably benign Het
Afg3l1 T A 8: 123,487,389 F190I probably benign Het
Alms1 T A 6: 85,641,371 S2800T possibly damaging Het
Alox5 A T 6: 116,415,517 W348R probably damaging Het
Atp13a5 G A 16: 29,267,014 Q823* probably null Het
Atp6v1b2 T C 8: 69,088,934 probably null Het
Chuk T C 19: 44,088,023 I416M possibly damaging Het
Dmbt1 A T 7: 131,099,290 Q1066L possibly damaging Het
Dnah5 A G 15: 28,421,620 T3873A probably damaging Het
Endog C T 2: 30,172,900 T184M probably damaging Het
Fam166b G A 4: 43,428,158 R100W possibly damaging Het
Fcgbp T C 7: 28,101,541 probably benign Het
Flii A G 11: 60,715,833 I1061T probably benign Het
Hdac2 T A 10: 36,997,071 N308K probably damaging Het
Hoxa2 T G 6: 52,163,517 Y163S probably damaging Het
Hsd3b7 T C 7: 127,802,972 L263P probably damaging Het
Klf17 T C 4: 117,761,038 T41A probably benign Het
Lrrfip1 T C 1: 91,068,621 M42T probably damaging Het
Mapk8ip1 C T 2: 92,385,188 V614I probably benign Het
Mocs1 T G 17: 49,435,264 probably null Het
Moxd1 T C 10: 24,282,555 probably benign Het
Mterf1a T C 5: 3,891,610 E86G probably damaging Het
Muc4 A G 16: 32,753,185 D1021G probably benign Het
Nomo1 T C 7: 46,045,336 S212P possibly damaging Het
Olfr1471 A G 19: 13,445,624 D204G probably benign Het
Olfr893 T A 9: 38,209,238 Y60N probably damaging Het
Phf21a A C 2: 92,348,029 T385P probably damaging Het
Piwil4 A T 9: 14,715,031 probably benign Het
Pknox1 T C 17: 31,599,645 probably null Het
Prr14l T C 5: 32,831,066 I362V probably benign Het
Sergef C T 7: 46,635,420 probably null Het
Sez6l T C 5: 112,424,645 D948G probably damaging Het
Skor1 A T 9: 63,146,441 L54Q probably damaging Het
Syde2 A G 3: 146,014,341 K772E possibly damaging Het
Taf2 T A 15: 55,071,449 probably null Het
Tbc1d13 T A 2: 30,140,511 Y113N probably damaging Het
Tmem154 T C 3: 84,684,415 F91L probably benign Het
Tmem63a A G 1: 180,966,497 D533G possibly damaging Het
Tmprss15 A T 16: 78,985,994 N712K possibly damaging Het
Trip12 A T 1: 84,730,541 D603E probably damaging Het
Trmt11 T C 10: 30,566,449 D246G probably damaging Het
Vmn1r174 T A 7: 23,754,533 M208K possibly damaging Het
Wdr54 T C 6: 83,155,773 H33R probably benign Het
Zfp207 A G 11: 80,389,002 D111G probably benign Het
Other mutations in Sntn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03338:Sntn APN 14 13678991 missense probably damaging 1.00
IGL03390:Sntn APN 14 13682205 splice site probably benign
R3902:Sntn UTSW 14 13679084 missense probably damaging 1.00
R4865:Sntn UTSW 14 13679103 missense probably benign
R5494:Sntn UTSW 14 13682214 missense probably benign
R7000:Sntn UTSW 14 13679108 missense probably damaging 0.98
Posted On2012-12-06