Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00155:Igsf6'

1443

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Igsf6

Ensembl Gene

ENSMUSG00000035004

Gene Name

immunoglobulin superfamily, member 6

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL00155

Quality Score

Status

Chromosome

Chromosomal Location

120663290-120673753 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 120669876 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 89 (K89*)

Ref Sequence

ENSEMBL: ENSMUSP00000039059 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000033163] [ENSMUST00000047194] [ENSMUST00000207351]

AlphaFold

P0C6B7

Predicted Effect

probably benign
Transcript: ENSMUST00000033163

SMART Domains

Protein: ENSMUSP00000033163
Gene: ENSMUSG00000030876

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
low complexity region	39	50	N/A	INTRINSIC
Pfam:DREV	56	317	1.4e-142	PFAM
Pfam:Methyltransf_23	123	289	2.7e-12	PFAM
Pfam:Methyltransf_12	150	236	9.1e-10	PFAM
Pfam:Methyltransf_11	150	238	9.4e-8	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000047194
AA Change: K89*

SMART Domains

Protein: ENSMUSP00000039059
Gene: ENSMUSG00000035004
AA Change: K89*

Domain	Start	End	E-Value	Type
IG	35	142	2.79e-2	SMART
transmembrane domain	154	176	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000207351

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000207835

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aacs	T	C	5: 125,590,235 (GRCm39)	F498S	probably damaging	Het
Arhgap11a	A	G	2: 113,664,601 (GRCm39)	S561P	probably benign	Het
Best3	T	C	10: 116,824,632 (GRCm39)	Y33H	probably damaging	Het
Cd209b	T	A	8: 3,969,945 (GRCm39)		probably benign	Het
Cep152	A	G	2: 125,405,808 (GRCm39)	S1575P	probably benign	Het
Crabp2	A	G	3: 87,859,506 (GRCm39)	Y52C	probably damaging	Het
Crybg1	T	C	10: 43,868,505 (GRCm39)	D1017G	probably damaging	Het
Ctnna2	A	T	6: 76,957,744 (GRCm39)	W137R	probably damaging	Het
Cxcl9	T	A	5: 92,471,728 (GRCm39)	H104L	possibly damaging	Het
Ddr2	A	G	1: 169,811,996 (GRCm39)	I742T	possibly damaging	Het
Frem1	A	G	4: 82,877,626 (GRCm39)	V223A	possibly damaging	Het
Fzd10	T	A	5: 128,678,592 (GRCm39)	I104N	probably damaging	Het
Greb1	A	G	12: 16,761,962 (GRCm39)	S473P	probably damaging	Het
Gtf2i	T	C	5: 134,271,602 (GRCm39)	Y873C	probably damaging	Het
Ints3	A	G	3: 90,313,636 (GRCm39)	F331L	probably damaging	Het
Kcnh3	A	T	15: 99,140,354 (GRCm39)	H1080L	possibly damaging	Het
Mettl15	A	T	2: 108,923,521 (GRCm39)	Y300*	probably null	Het
Mms19	A	G	19: 41,936,672 (GRCm39)	F654L	probably benign	Het
Myc	A	G	15: 61,861,669 (GRCm39)	H425R	probably benign	Het
Ntn1	G	T	11: 68,117,445 (GRCm39)		probably benign	Het
Ormdl2	C	A	10: 128,655,944 (GRCm39)	G69W	probably damaging	Het
Pdpr	T	C	8: 111,828,704 (GRCm39)	V69A	possibly damaging	Het
Rbbp6	T	C	7: 122,587,908 (GRCm39)	I254T	probably damaging	Het
Sema6d	A	G	2: 124,501,785 (GRCm39)	R543G	possibly damaging	Het
Slc18a1	C	T	8: 69,503,998 (GRCm39)	A314T	probably damaging	Het
Slc22a26	A	G	19: 7,760,201 (GRCm39)	L514P	probably damaging	Het
Slc22a28	A	C	19: 8,107,567 (GRCm39)	S167A	possibly damaging	Het
Speer1m	A	G	5: 11,971,377 (GRCm39)	S110G	possibly damaging	Het
Tchh	A	G	3: 93,352,606 (GRCm39)	E682G	unknown	Het
Thbs2	A	T	17: 14,889,097 (GRCm39)	M1134K	probably damaging	Het
Tmem26	A	G	10: 68,611,184 (GRCm39)	S218G	probably damaging	Het
Tmprss11c	A	T	5: 86,387,254 (GRCm39)	S208R	probably benign	Het
Tnfrsf8	T	C	4: 145,019,161 (GRCm39)		probably null	Het
Ush2a	T	C	1: 188,596,875 (GRCm39)	S3872P	probably benign	Het
Vmn1r69	T	C	7: 10,313,879 (GRCm39)	N205S	probably benign	Het
Vmn2r54	T	A	7: 12,365,840 (GRCm39)		probably benign	Het
Wwtr1	A	T	3: 57,370,942 (GRCm39)	M328K	possibly damaging	Het
Zfp64	G	A	2: 168,768,601 (GRCm39)	S337L	probably benign	Het

Other mutations in Igsf6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01592:Igsf6	APN	7	120,670,016 (GRCm39)	missense	probably damaging	1.00
IGL02519:Igsf6	APN	7	120,667,496 (GRCm39)	missense	possibly damaging	0.72
IGL02636:Igsf6	APN	7	120,666,503 (GRCm39)	intron	probably benign
R0106:Igsf6	UTSW	7	120,673,677 (GRCm39)	missense	probably benign	0.28
R0106:Igsf6	UTSW	7	120,673,677 (GRCm39)	missense	probably benign	0.28
R1776:Igsf6	UTSW	7	120,667,522 (GRCm39)	missense	probably damaging	0.97
R1817:Igsf6	UTSW	7	120,670,031 (GRCm39)	missense	probably damaging	1.00
R7770:Igsf6	UTSW	7	120,667,548 (GRCm39)	missense	probably benign	0.01
R9435:Igsf6	UTSW	7	120,666,472 (GRCm39)	missense	probably damaging	1.00
R9500:Igsf6	UTSW	7	120,673,697 (GRCm39)	missense	probably benign	0.03

Posted On

2011-07-12