Incidental Mutation 'IGL00743:Tnfsf15'
ID 14525
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tnfsf15
Ensembl Gene ENSMUSG00000050395
Gene Name tumor necrosis factor (ligand) superfamily, member 15
Synonyms TL1A, VEGI, TL1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # IGL00743
Quality Score
Status
Chromosome 4
Chromosomal Location 63642837-63663296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 63652518 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 98 (R98G)
Ref Sequence ENSEMBL: ENSMUSP00000050144 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062246]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000062246
AA Change: R98G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000050144
Gene: ENSMUSG00000050395
AA Change: R98G

DomainStartEndE-ValueType
transmembrane domain 56 78 N/A INTRINSIC
TNF 114 270 1.25e-28 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
PHENOTYPE: Homozygous targeted mutants display decreased clinical severity in experimental autoimmune encephalomyelitis (EAE) and collagen-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss1 T C 2: 150,461,606 (GRCm39) E659G probably benign Het
Adgrg6 A C 10: 14,411,703 (GRCm39) probably benign Het
Als2cl A G 9: 110,718,227 (GRCm39) K323E possibly damaging Het
Atm A C 9: 53,424,416 (GRCm39) S628R probably benign Het
Baz2a T C 10: 127,950,395 (GRCm39) V443A probably benign Het
Bclaf3 T A X: 158,341,357 (GRCm39) F545Y probably benign Het
Calcr T C 6: 3,717,196 (GRCm39) Y88C probably damaging Het
Ccdc178 C T 18: 22,278,501 (GRCm39) probably benign Het
Cdh20 A G 1: 104,875,153 (GRCm39) T312A probably benign Het
Chrnd G A 1: 87,120,649 (GRCm39) W91* probably null Het
Cntln T C 4: 84,897,652 (GRCm39) F413S probably benign Het
Ctsq A T 13: 61,183,998 (GRCm39) I308N probably damaging Het
Cyp2d34 A T 15: 82,501,736 (GRCm39) V258D probably damaging Het
Dnajc13 G A 9: 104,039,979 (GRCm39) P2044S probably benign Het
Hnrnpm C A 17: 33,868,876 (GRCm39) R517L probably damaging Het
Hps6 A T 19: 45,992,099 (GRCm39) D12V probably damaging Het
Hpse T C 5: 100,846,865 (GRCm39) D188G probably benign Het
Id2 C A 12: 25,145,355 (GRCm39) E123* probably null Het
Ints10 C T 8: 69,271,985 (GRCm39) P562L probably damaging Het
Kctd10 G A 5: 114,505,410 (GRCm39) R195C probably damaging Het
Kel A C 6: 41,665,509 (GRCm39) L537R probably damaging Het
Kif19a T C 11: 114,675,599 (GRCm39) V357A probably damaging Het
Lrrtm3 A T 10: 63,924,988 (GRCm39) S60T probably damaging Het
Myof C A 19: 37,949,382 (GRCm39) R608L probably benign Het
Naa35 A T 13: 59,778,485 (GRCm39) I669F probably benign Het
Or8g2b A T 9: 39,751,002 (GRCm39) I91F probably benign Het
Or8g53 A G 9: 39,683,407 (GRCm39) S230P possibly damaging Het
Pclo G T 5: 14,728,035 (GRCm39) probably benign Het
Pik3c3 C T 18: 30,407,417 (GRCm39) S55F probably damaging Het
Prdm6 T G 18: 53,673,300 (GRCm39) D153E possibly damaging Het
Rnf183 T C 4: 62,346,610 (GRCm39) T63A probably benign Het
Samd4b A C 7: 28,101,302 (GRCm39) I108S probably damaging Het
Slc9a7 T C X: 19,972,260 (GRCm39) D708G possibly damaging Het
Stim2 A G 5: 54,210,835 (GRCm39) D90G probably benign Het
Tmem52b A G 6: 129,493,678 (GRCm39) D97G probably damaging Het
Uxs1 C T 1: 43,796,173 (GRCm39) V310I probably benign Het
Vcan A C 13: 89,873,425 (GRCm39) M143R probably damaging Het
Vmn2r93 T C 17: 18,546,504 (GRCm39) F792S probably damaging Het
Zfp455 T C 13: 67,355,962 (GRCm39) I345T probably benign Het
Zfp938 A T 10: 82,062,317 (GRCm39) M101K probably benign Het
Zkscan2 A G 7: 123,079,195 (GRCm39) S921P probably damaging Het
Other mutations in Tnfsf15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00674:Tnfsf15 APN 4 63,652,483 (GRCm39) splice site probably benign
IGL03189:Tnfsf15 APN 4 63,648,289 (GRCm39) splice site probably benign
R0158:Tnfsf15 UTSW 4 63,648,229 (GRCm39) missense possibly damaging 0.95
R1824:Tnfsf15 UTSW 4 63,651,588 (GRCm39) missense probably benign 0.03
R3122:Tnfsf15 UTSW 4 63,652,522 (GRCm39) missense probably benign 0.00
R4595:Tnfsf15 UTSW 4 63,648,180 (GRCm39) nonsense probably null
R5025:Tnfsf15 UTSW 4 63,648,125 (GRCm39) missense probably benign 0.01
R6123:Tnfsf15 UTSW 4 63,663,162 (GRCm39) missense probably benign 0.00
R6376:Tnfsf15 UTSW 4 63,663,267 (GRCm39) missense probably damaging 0.98
R7104:Tnfsf15 UTSW 4 63,647,887 (GRCm39) missense probably damaging 1.00
R7173:Tnfsf15 UTSW 4 63,647,889 (GRCm39) missense probably damaging 1.00
R9448:Tnfsf15 UTSW 4 63,663,305 (GRCm39) missense possibly damaging 0.46
Posted On 2012-12-06