Incidental Mutation 'IGL00811:Trim13'
ID14568
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim13
Ensembl Gene ENSMUSG00000035235
Gene Nametripartite motif-containing 13
SynonymsLEU5, RNF77, Rfp2, 3110001L12Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00811
Quality Score
Status
Chromosome14
Chromosomal Location61598247-61605946 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) A to G at 61604857 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039562] [ENSMUST00000051184] [ENSMUST00000165015] [ENSMUST00000225582]
Predicted Effect probably damaging
Transcript: ENSMUST00000039562
AA Change: T108A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045009
Gene: ENSMUSG00000035235
AA Change: T108A

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000051184
SMART Domains Protein: ENSMUSP00000055327
Gene: ENSMUSG00000046168

DomainStartEndE-ValueType
BTB 5 106 8.7e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000165015
AA Change: T108A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000128509
Gene: ENSMUSG00000035235
AA Change: T108A

DomainStartEndE-ValueType
RING 10 57 1.31e-8 SMART
BBOX 89 131 5.55e-12 SMART
transmembrane domain 316 338 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182259
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182325
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183054
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183066
Predicted Effect probably null
Transcript: ENSMUST00000225582
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agps T C 2: 75,925,972 F649L probably benign Het
Agrn A T 4: 156,168,774 D1752E possibly damaging Het
Det1 A G 7: 78,840,059 V406A probably benign Het
Dhx57 A G 17: 80,253,243 V955A probably damaging Het
Dpep1 T C 8: 123,199,615 probably benign Het
Epha7 T A 4: 28,961,285 probably benign Het
Faim G A 9: 98,992,165 G15R probably damaging Het
Fbxl5 A G 5: 43,758,225 L614P probably damaging Het
Fem1b A T 9: 62,796,919 V353D probably damaging Het
Fgf22 C T 10: 79,756,890 P140S probably damaging Het
Ifi47 T C 11: 49,095,417 F4L probably benign Het
Kmt2c A C 5: 25,374,533 S588R possibly damaging Het
Nmrk1 T A 19: 18,645,147 probably benign Het
Nomo1 C T 7: 46,083,308 A1165V possibly damaging Het
Osmr G A 15: 6,815,666 T873I probably benign Het
Pclo A G 5: 14,680,010 probably benign Het
Rims2 T A 15: 39,292,149 M115K probably damaging Het
Rora C A 9: 69,371,290 T299K probably benign Het
Sema6d C A 2: 124,658,469 P386Q probably damaging Het
Slit2 G A 5: 47,989,151 E95K possibly damaging Het
Sox18 T C 2: 181,670,420 E306G probably benign Het
Sptlc1 C A 13: 53,367,378 A121S probably damaging Het
Ssh2 C T 11: 77,441,926 A411V probably damaging Het
Vps13c T A 9: 67,948,181 N2509K probably damaging Het
Other mutations in Trim13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00788:Trim13 APN 14 61605670 missense probably benign
IGL01760:Trim13 APN 14 61605723 missense probably benign 0.06
IGL02411:Trim13 APN 14 61605149 missense probably damaging 1.00
IGL02625:Trim13 APN 14 61605550 missense probably benign 0.00
IGL02926:Trim13 APN 14 61605244 unclassified probably null
IGL03231:Trim13 APN 14 61605545 missense probably benign 0.11
R0089:Trim13 UTSW 14 61604717 missense possibly damaging 0.95
R0811:Trim13 UTSW 14 61605700 missense probably benign
R0812:Trim13 UTSW 14 61605700 missense probably benign
R1515:Trim13 UTSW 14 61605659 missense probably benign 0.03
R1778:Trim13 UTSW 14 61605619 missense probably benign 0.13
R2018:Trim13 UTSW 14 61604886 nonsense probably null
R2019:Trim13 UTSW 14 61604886 nonsense probably null
R4865:Trim13 UTSW 14 61605517 missense probably benign
R5456:Trim13 UTSW 14 61605074 missense possibly damaging 0.91
R5860:Trim13 UTSW 14 61604739 missense probably damaging 0.96
R5921:Trim13 UTSW 14 61605089 missense probably benign 0.00
R7026:Trim13 UTSW 14 61605113 nonsense probably null
R7147:Trim13 UTSW 14 61604631 missense probably damaging 1.00
Posted On2012-12-06