Incidental Mutation 'IGL00092:Or14a260'
ID 1472
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or14a260
Ensembl Gene ENSMUSG00000055610
Gene Name olfactory receptor family 14 subfamily A member 260
Synonyms Olfr307, GA_x6K02T2NHDJ-9772012-9772953, MOR219-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # IGL00092
Quality Score
Status
Chromosome 7
Chromosomal Location 85984661-85985602 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85985269 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 112 (V112I)
Ref Sequence ENSEMBL: ENSMUSP00000149779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069279] [ENSMUST00000213705] [ENSMUST00000217494]
AlphaFold Q8VFN8
Predicted Effect probably benign
Transcript: ENSMUST00000069279
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000063538
Gene: ENSMUSG00000055610
AA Change: V112I

DomainStartEndE-ValueType
low complexity region 5 16 N/A INTRINSIC
Pfam:7tm_4 29 306 1.6e-42 PFAM
Pfam:7tm_1 39 288 9.8e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213705
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217494
AA Change: V112I

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T C 12: 118,892,430 (GRCm39) D443G probably benign Het
Atg16l1 T C 1: 87,693,119 (GRCm39) I28T possibly damaging Het
Bpi T A 2: 158,116,716 (GRCm39) V371E probably damaging Het
Cd109 T G 9: 78,524,251 (GRCm39) V55G probably damaging Het
Cd300c2 T C 11: 114,892,375 (GRCm39) probably benign Het
Cic C T 7: 24,991,549 (GRCm39) R1280C probably damaging Het
Cngb1 G A 8: 95,968,812 (GRCm39) probably benign Het
Cntn4 G T 6: 106,483,186 (GRCm39) C247F probably damaging Het
Disp3 C T 4: 148,325,991 (GRCm39) V1256I probably benign Het
Farsb A T 1: 78,439,630 (GRCm39) S338T probably benign Het
Fcnb T C 2: 27,966,813 (GRCm39) N240S probably benign Het
Flg2 A G 3: 93,127,162 (GRCm39) S5G possibly damaging Het
Git1 T C 11: 77,396,783 (GRCm39) L635P probably benign Het
Gm21985 T G 2: 112,181,679 (GRCm39) W685G probably damaging Het
Gpt2 T C 8: 86,238,953 (GRCm39) V262A probably benign Het
Hecw2 A G 1: 53,869,896 (GRCm39) V1444A probably damaging Het
Herc1 T C 9: 66,391,248 (GRCm39) V4017A probably benign Het
Klhl17 T C 4: 156,318,147 (GRCm39) T129A possibly damaging Het
Krt84 T G 15: 101,437,170 (GRCm39) D331A probably damaging Het
Lrrc9 C T 12: 72,533,017 (GRCm39) T963M possibly damaging Het
Mtcl1 C T 17: 66,651,314 (GRCm39) V935I probably benign Het
Muc4 G A 16: 32,754,086 (GRCm38) G1321R probably benign Het
Myocd T C 11: 65,071,770 (GRCm39) probably null Het
Nid1 A G 13: 13,650,977 (GRCm39) N505D probably damaging Het
Ninj1 A T 13: 49,347,210 (GRCm39) probably null Het
Or1x6 C A 11: 50,939,227 (GRCm39) Q98K probably benign Het
Or4d10c A T 19: 12,065,357 (GRCm39) D266E probably benign Het
Plscr2 T A 9: 92,172,685 (GRCm39) probably benign Het
Ppfia2 A G 10: 106,655,353 (GRCm39) T307A probably benign Het
Sart3 T C 5: 113,884,730 (GRCm39) R625G probably benign Het
Sohlh2 T A 3: 55,115,236 (GRCm39) L407H probably damaging Het
Sorcs1 A G 19: 50,178,492 (GRCm39) S877P probably damaging Het
Stat1 T C 1: 52,161,754 (GRCm39) M1T probably null Het
Szt2 C T 4: 118,241,447 (GRCm39) probably benign Het
Tars3 G T 7: 65,302,007 (GRCm39) probably null Het
Terb2 T A 2: 122,028,867 (GRCm39) S141R probably benign Het
Tgfbrap1 T C 1: 43,099,283 (GRCm39) Y177C probably damaging Het
Trappc9 A T 15: 72,897,875 (GRCm39) I169N possibly damaging Het
Trim47 A G 11: 115,997,020 (GRCm39) L578P probably damaging Het
Usp34 G A 11: 23,386,020 (GRCm39) R2149H probably damaging Het
Vmn2r90 T C 17: 17,953,758 (GRCm39) S641P probably benign Het
Vwa5a T A 9: 38,649,110 (GRCm39) probably null Het
Zzef1 T A 11: 72,765,952 (GRCm39) I1493N probably benign Het
Other mutations in Or14a260
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02419:Or14a260 APN 7 85,984,870 (GRCm39) missense probably damaging 0.98
IGL02519:Or14a260 APN 7 85,984,789 (GRCm39) missense probably benign 0.01
IGL02750:Or14a260 APN 7 85,984,752 (GRCm39) missense probably damaging 1.00
R0123:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0134:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R0225:Or14a260 UTSW 7 85,984,803 (GRCm39) missense probably benign 0.02
R1025:Or14a260 UTSW 7 85,985,113 (GRCm39) missense probably benign 0.09
R1511:Or14a260 UTSW 7 85,985,553 (GRCm39) missense possibly damaging 0.49
R1674:Or14a260 UTSW 7 85,984,765 (GRCm39) missense probably damaging 1.00
R2011:Or14a260 UTSW 7 85,984,955 (GRCm39) nonsense probably null
R4588:Or14a260 UTSW 7 85,984,852 (GRCm39) missense probably benign 0.00
R5637:Or14a260 UTSW 7 85,984,812 (GRCm39) missense probably benign 0.00
R6163:Or14a260 UTSW 7 85,985,592 (GRCm39) missense possibly damaging 0.84
R6407:Or14a260 UTSW 7 85,985,277 (GRCm39) missense possibly damaging 0.90
R7342:Or14a260 UTSW 7 85,985,295 (GRCm39) missense probably benign 0.00
R8066:Or14a260 UTSW 7 85,985,014 (GRCm39) missense probably benign 0.00
R8155:Or14a260 UTSW 7 85,985,386 (GRCm39) missense probably damaging 1.00
R8158:Or14a260 UTSW 7 85,984,885 (GRCm39) missense probably benign 0.01
Posted On 2011-07-12