Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00832:Vmn1r188'

14783

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r188

Ensembl Gene

ENSMUSG00000069299

Gene Name

vomeronasal 1 receptor 188

Synonyms

V1rh17

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL00832

Quality Score

Status

Chromosome

Chromosomal Location

22272048-22272974 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 22272351 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 102 (T102A)

Ref Sequence

ENSEMBL: ENSMUSP00000154654 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091739] [ENSMUST00000226680] [ENSMUST00000228243]

AlphaFold

Q8K3N2

Predicted Effect

probably damaging
Transcript: ENSMUST00000091739
AA Change: T102A

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000089333
Gene: ENSMUSG00000069299
AA Change: T102A

Domain	Start	End	E-Value	Type
Pfam:V1R	32	297	1.5e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000102282

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118443

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122016

Predicted Effect

probably damaging
Transcript: ENSMUST00000226680
AA Change: T102A

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

Predicted Effect

probably damaging
Transcript: ENSMUST00000228243
AA Change: T102A

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700030K09Rik	A	G	8: 73,209,193 (GRCm39)	Y407C	probably damaging	Het
Amtn	T	G	5: 88,532,908 (GRCm39)	H174Q	possibly damaging	Het
Cdon	T	A	9: 35,389,412 (GRCm39)	I839N	probably damaging	Het
Ces2g	A	G	8: 105,694,471 (GRCm39)		probably benign	Het
Cgas	A	T	9: 78,341,599 (GRCm39)	C393S	probably damaging	Het
Colq	G	T	14: 31,250,303 (GRCm39)	C367*	probably null	Het
Dop1b	T	C	16: 93,560,289 (GRCm39)	V745A	probably benign	Het
E2f8	C	T	7: 48,517,951 (GRCm39)	G657D	probably damaging	Het
Gpcpd1	G	A	2: 132,388,770 (GRCm39)	T334M	probably damaging	Het
Gria2	T	C	3: 80,614,558 (GRCm39)	D494G	probably damaging	Het
Gtf3c1	T	C	7: 125,253,632 (GRCm39)		probably benign	Het
Gtf3c2	G	A	5: 31,330,349 (GRCm39)		probably benign	Het
Hnf4g	G	A	3: 3,706,336 (GRCm39)	C77Y	probably damaging	Het
Ido1	G	A	8: 25,074,575 (GRCm39)	T265I	possibly damaging	Het
Ifih1	A	G	2: 62,475,814 (GRCm39)		probably benign	Het
Itga6	A	G	2: 71,668,606 (GRCm39)		probably null	Het
Kctd10	C	A	5: 114,506,997 (GRCm39)		probably null	Het
Ltk	A	T	2: 119,586,086 (GRCm39)		probably benign	Het
Luc7l3	T	C	11: 94,194,768 (GRCm39)	D84G	probably benign	Het
Mc3r	A	T	2: 172,090,948 (GRCm39)	I57F	possibly damaging	Het
Mmp1b	T	A	9: 7,387,023 (GRCm39)	Q63L	possibly damaging	Het
Ncr1	C	A	7: 4,344,287 (GRCm39)	T225N	possibly damaging	Het
Nf2	T	C	11: 4,741,123 (GRCm39)	K364E	probably benign	Het
Ppl	A	T	16: 4,906,839 (GRCm39)	L1152H	probably damaging	Het
Primpol	A	G	8: 47,034,632 (GRCm39)	V432A	probably damaging	Het
Rbl2	A	G	8: 91,812,073 (GRCm39)	D214G	probably damaging	Het
Rxfp2	A	T	5: 149,989,893 (GRCm39)	M425L	probably benign	Het
Slc5a3	T	C	16: 91,874,519 (GRCm39)	M192T	probably damaging	Het
Tbx18	T	A	9: 87,587,714 (GRCm39)	S468C	probably damaging	Het
Tex10	T	C	4: 48,468,864 (GRCm39)	T104A	probably benign	Het
Unc13b	T	G	4: 43,258,921 (GRCm39)	V4153G	probably damaging	Het

Other mutations in Vmn1r188

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02750:Vmn1r188	APN	13	22,272,900 (GRCm39)	missense	probably damaging	1.00
R1545:Vmn1r188	UTSW	13	22,272,603 (GRCm39)	missense	probably damaging	1.00
R1895:Vmn1r188	UTSW	13	22,272,815 (GRCm39)	missense	possibly damaging	0.88
R1946:Vmn1r188	UTSW	13	22,272,815 (GRCm39)	missense	possibly damaging	0.88
R1952:Vmn1r188	UTSW	13	22,272,309 (GRCm39)	missense	probably damaging	1.00
R4090:Vmn1r188	UTSW	13	22,272,772 (GRCm39)	missense	probably benign	0.01
R4571:Vmn1r188	UTSW	13	22,272,688 (GRCm39)	missense	probably benign	0.23
R4836:Vmn1r188	UTSW	13	22,272,291 (GRCm39)	missense	probably benign	0.17
R5641:Vmn1r188	UTSW	13	22,272,342 (GRCm39)	missense	probably damaging	1.00
R5820:Vmn1r188	UTSW	13	22,272,256 (GRCm39)	missense	possibly damaging	0.60
R6236:Vmn1r188	UTSW	13	22,272,414 (GRCm39)	missense	probably damaging	0.99
R8025:Vmn1r188	UTSW	13	22,272,084 (GRCm39)	missense	probably benign	0.00
R9233:Vmn1r188	UTSW	13	22,272,399 (GRCm39)	missense	probably benign	0.12
R9405:Vmn1r188	UTSW	13	22,272,898 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn1r188	UTSW	13	22,272,450 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06