Incidental Mutation 'IGL00870:Vmn1r220'
ID14787
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r220
Ensembl Gene ENSMUSG00000096099
Gene Namevomeronasal 1 receptor 220
SynonymsV1rh12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL00870
Quality Score
Status
Chromosome13
Chromosomal Location23178514-23187975 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 23184477 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Isoleucine at position 16 (M16I)
Ref Sequence ENSEMBL: ENSMUSP00000072222 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072385] [ENSMUST00000226651] [ENSMUST00000227679] [ENSMUST00000227950] [ENSMUST00000228239] [ENSMUST00000228854]
Predicted Effect probably null
Transcript: ENSMUST00000072385
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000072222
Gene: ENSMUSG00000096099
AA Change: M16I

DomainStartEndE-ValueType
Pfam:V1R 33 297 5e-38 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226651
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000227679
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000227950
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000228239
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000228854
AA Change: M16I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak T A 19: 9,013,698 D4115E probably damaging Het
Asb5 T C 8: 54,583,660 probably null Het
Cpeb3 A T 19: 37,054,295 I569N probably damaging Het
Cpsf7 T C 19: 10,539,650 probably null Het
Dlat A G 9: 50,650,869 L285P probably damaging Het
Dytn T C 1: 63,677,113 probably benign Het
Ears2 A T 7: 122,055,676 L123Q probably damaging Het
Gad2 T C 2: 22,629,971 V212A probably benign Het
Gon4l T C 3: 88,857,185 Y358H probably damaging Het
Gys1 T C 7: 45,448,013 probably null Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Krtap20-2 G A 16: 89,205,987 G25D unknown Het
Lrif1 T C 3: 106,734,641 probably null Het
Naip2 A G 13: 100,152,060 probably benign Het
Olfr884 A T 9: 38,047,740 I173F probably damaging Het
Oxct1 T A 15: 4,101,818 L396Q probably damaging Het
Pclo A T 5: 14,539,983 R766W unknown Het
Pkhd1 T A 1: 20,571,390 I275F probably damaging Het
Rxfp3 A G 15: 11,036,215 F357S probably damaging Het
Rxfp3 A G 15: 11,036,305 V327A probably damaging Het
Serpinb2 A G 1: 107,523,070 I181V probably damaging Het
Smad5 A G 13: 56,723,667 D25G probably benign Het
Strada A G 11: 106,171,257 L82P probably damaging Het
Tek T A 4: 94,873,081 Y1079* probably null Het
Tenm3 T C 8: 48,417,132 T209A probably benign Het
Tnks1bp1 C T 2: 85,062,236 Q836* probably null Het
Toporsl T C 4: 52,610,172 S22P probably benign Het
Ttc17 T C 2: 94,371,733 probably null Het
Ttc39a A G 4: 109,442,345 probably benign Het
Vangl1 T C 3: 102,189,440 D60G probably damaging Het
Vmn1r13 A T 6: 57,210,113 M86L probably benign Het
Other mutations in Vmn1r220
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Vmn1r220 APN 13 23183765 missense probably benign 0.00
IGL00972:Vmn1r220 APN 13 23184388 missense probably damaging 1.00
IGL01511:Vmn1r220 APN 13 23184214 missense probably damaging 1.00
IGL02967:Vmn1r220 APN 13 23183992 missense probably damaging 0.97
IGL03040:Vmn1r220 APN 13 23183782 missense possibly damaging 0.92
R1226:Vmn1r220 UTSW 13 23184124 missense probably damaging 1.00
R1869:Vmn1r220 UTSW 13 23184287 missense probably damaging 1.00
R2312:Vmn1r220 UTSW 13 23183977 missense probably damaging 1.00
R4223:Vmn1r220 UTSW 13 23183978 missense probably benign 0.22
R5655:Vmn1r220 UTSW 13 23184128 missense probably benign 0.03
R6188:Vmn1r220 UTSW 13 23183914 missense probably damaging 1.00
R6276:Vmn1r220 UTSW 13 23184295 missense probably damaging 1.00
Posted On2012-12-06