Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00321:Vmn2r66'

14797

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r66

Ensembl Gene

ENSMUSG00000094950

Gene Name

vomeronasal 2, receptor 66

Synonyms

F830104D24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL00321

Quality Score

Status

Chromosome

Chromosomal Location

84643853-84661228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 84656299 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 239 (Q239L)

Ref Sequence

ENSEMBL: ENSMUSP00000122645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124773]

AlphaFold

A0A3B2W842

Predicted Effect

probably benign
Transcript: ENSMUST00000124773
AA Change: Q239L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: Q239L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	463	5e-31	PFAM
Pfam:NCD3G	507	559	6e-21	PFAM
Pfam:7tm_3	589	827	3.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 28 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34l	A	G	8: 44,078,418 (GRCm39)	I602T	probably benign	Het
Adam39	A	G	8: 41,279,783 (GRCm39)	R725G	possibly damaging	Het
Arid2	A	G	15: 96,186,970 (GRCm39)	E74G	probably damaging	Het
Carf	T	A	1: 60,164,001 (GRCm39)		probably benign	Het
Cit	A	T	5: 115,984,524 (GRCm39)	Q32L	probably damaging	Het
Dennd4b	A	G	3: 90,178,514 (GRCm39)	T526A	possibly damaging	Het
Dnhd1	A	G	7: 105,327,202 (GRCm39)	E717G	probably damaging	Het
Ercc6	T	A	14: 32,290,029 (GRCm39)	I968N	probably damaging	Het
Fcrl1	A	T	3: 87,296,942 (GRCm39)	Y297F	probably damaging	Het
Gas2l3	A	G	10: 89,249,489 (GRCm39)	L543P	probably benign	Het
Hid1	A	T	11: 115,249,895 (GRCm39)	D84E	probably benign	Het
Ifit1bl2	C	T	19: 34,597,319 (GRCm39)	S99N	probably benign	Het
Kpna3	A	G	14: 61,629,302 (GRCm39)		probably benign	Het
Myadm	C	A	7: 3,345,739 (GRCm39)	P167Q	possibly damaging	Het
Ociad1	C	T	5: 73,461,886 (GRCm39)		probably benign	Het
Or2t43	A	C	11: 58,457,593 (GRCm39)	Y193D	probably damaging	Het
Pcdh11x	A	T	X: 119,502,265 (GRCm39)	K1029N	probably benign	Het
Pcdhb11	A	G	18: 37,555,026 (GRCm39)	T119A	probably benign	Het
Phldb2	T	C	16: 45,592,617 (GRCm39)	R926G	probably damaging	Het
Ppwd1	A	G	13: 104,353,651 (GRCm39)	F369S	probably damaging	Het
Rreb1	T	A	13: 38,100,472 (GRCm39)	M201K	probably benign	Het
Ryr1	A	T	7: 28,802,235 (GRCm39)	I795N	probably damaging	Het
Slc3a1	T	C	17: 85,368,261 (GRCm39)	W510R	probably damaging	Het
Slc44a5	T	C	3: 153,968,576 (GRCm39)	L589P	probably damaging	Het
Tfr2	A	G	5: 137,572,717 (GRCm39)	D176G	probably null	Het
Tom1	T	A	8: 75,778,802 (GRCm39)	S24T	probably benign	Het
Ythdc2	A	G	18: 44,993,040 (GRCm39)	T149A	probably benign	Het
Zc3h3	A	G	15: 75,651,162 (GRCm39)	I686T	probably damaging	Het

Other mutations in Vmn2r66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01562:Vmn2r66	APN	7	84,656,495 (GRCm39)	missense	probably benign	0.03
IGL01689:Vmn2r66	APN	7	84,657,033 (GRCm39)	missense	probably damaging	1.00
IGL02237:Vmn2r66	APN	7	84,643,908 (GRCm39)	missense	probably benign
IGL02415:Vmn2r66	APN	7	84,656,020 (GRCm39)	missense	probably damaging	0.97
IGL02439:Vmn2r66	APN	7	84,654,455 (GRCm39)	splice site	probably benign
IGL02545:Vmn2r66	APN	7	84,655,798 (GRCm39)	missense	possibly damaging	0.50
IGL02708:Vmn2r66	APN	7	84,655,796 (GRCm39)	missense	probably benign	0.00
IGL02794:Vmn2r66	APN	7	84,644,623 (GRCm39)	missense	probably benign	0.00
IGL02885:Vmn2r66	APN	7	84,644,723 (GRCm39)	missense	probably benign	0.00
IGL02975:Vmn2r66	APN	7	84,656,182 (GRCm39)	missense	probably damaging	0.98
IGL03027:Vmn2r66	APN	7	84,644,777 (GRCm39)	splice site	probably benign
IGL03081:Vmn2r66	APN	7	84,657,138 (GRCm39)	missense	probably benign
PIT4131001:Vmn2r66	UTSW	7	84,644,301 (GRCm39)	missense	probably damaging	1.00
R0098:Vmn2r66	UTSW	7	84,654,965 (GRCm39)	missense	probably damaging	1.00
R0504:Vmn2r66	UTSW	7	84,656,023 (GRCm39)	missense	probably damaging	0.99
R0557:Vmn2r66	UTSW	7	84,643,972 (GRCm39)	missense	probably damaging	1.00
R0617:Vmn2r66	UTSW	7	84,644,484 (GRCm39)	missense	probably benign	0.02
R0883:Vmn2r66	UTSW	7	84,657,070 (GRCm39)	missense	probably benign
R1159:Vmn2r66	UTSW	7	84,644,613 (GRCm39)	missense	probably benign	0.44
R1168:Vmn2r66	UTSW	7	84,656,062 (GRCm39)	missense	possibly damaging	0.46
R1172:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1175:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1538:Vmn2r66	UTSW	7	84,644,166 (GRCm39)	missense	possibly damaging	0.84
R1658:Vmn2r66	UTSW	7	84,656,955 (GRCm39)	missense	probably benign	0.07
R1937:Vmn2r66	UTSW	7	84,644,344 (GRCm39)	missense	probably damaging	0.99
R1989:Vmn2r66	UTSW	7	84,661,201 (GRCm39)	missense	probably benign	0.01
R2698:Vmn2r66	UTSW	7	84,644,607 (GRCm39)	missense	probably damaging	1.00
R2890:Vmn2r66	UTSW	7	84,661,027 (GRCm39)	splice site	probably null
R3686:Vmn2r66	UTSW	7	84,644,397 (GRCm39)	missense	probably damaging	0.96
R4152:Vmn2r66	UTSW	7	84,654,800 (GRCm39)	missense	probably benign	0.08
R4500:Vmn2r66	UTSW	7	84,657,162 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r66	UTSW	7	84,644,296 (GRCm39)	missense	possibly damaging	0.62
R4656:Vmn2r66	UTSW	7	84,661,204 (GRCm39)	missense	possibly damaging	0.87
R4668:Vmn2r66	UTSW	7	84,643,905 (GRCm39)	missense	probably damaging	1.00
R4942:Vmn2r66	UTSW	7	84,656,980 (GRCm39)	missense	probably damaging	1.00
R5163:Vmn2r66	UTSW	7	84,656,017 (GRCm39)	missense	probably benign	0.01
R5223:Vmn2r66	UTSW	7	84,657,093 (GRCm39)	missense	probably benign
R5377:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R5512:Vmn2r66	UTSW	7	84,657,149 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r66	UTSW	7	84,654,951 (GRCm39)	nonsense	probably null
R5749:Vmn2r66	UTSW	7	84,655,979 (GRCm39)	nonsense	probably null
R6131:Vmn2r66	UTSW	7	84,644,224 (GRCm39)	missense	probably damaging	1.00
R6183:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R6509:Vmn2r66	UTSW	7	84,656,054 (GRCm39)	missense	probably benign	0.12
R6930:Vmn2r66	UTSW	7	84,661,216 (GRCm39)	missense	possibly damaging	0.80
R6992:Vmn2r66	UTSW	7	84,654,436 (GRCm39)	missense	possibly damaging	0.90
R7015:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R7302:Vmn2r66	UTSW	7	84,654,423 (GRCm39)	missense	probably benign	0.00
R7516:Vmn2r66	UTSW	7	84,661,176 (GRCm39)	missense	possibly damaging	0.51
R7763:Vmn2r66	UTSW	7	84,654,909 (GRCm39)	missense	probably benign	0.01
R7814:Vmn2r66	UTSW	7	84,656,472 (GRCm39)	missense	probably benign	0.02
R8077:Vmn2r66	UTSW	7	84,656,093 (GRCm39)	missense	probably benign
R8307:Vmn2r66	UTSW	7	84,656,270 (GRCm39)	missense	probably benign
R8315:Vmn2r66	UTSW	7	84,643,932 (GRCm39)	missense	possibly damaging	0.90
R8490:Vmn2r66	UTSW	7	84,654,794 (GRCm39)	critical splice donor site	probably null
R8511:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R8781:Vmn2r66	UTSW	7	84,644,355 (GRCm39)	nonsense	probably null
R8812:Vmn2r66	UTSW	7	84,654,893 (GRCm39)	missense	probably damaging	0.99
R9203:Vmn2r66	UTSW	7	84,654,950 (GRCm39)	missense	probably benign	0.01
R9277:Vmn2r66	UTSW	7	84,661,164 (GRCm39)	missense	probably benign	0.00

Posted On

2012-12-06