Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00340:Vsig10'

14821

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vsig10

Ensembl Gene

ENSMUSG00000066894

Gene Name

V-set and immunoglobulin domain containing 10

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL00340

Quality Score

Status

Chromosome

Chromosomal Location

117457331-117493071 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 117489652 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 473 (M473L)

Ref Sequence

ENSEMBL: ENSMUSP00000107598 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086464] [ENSMUST00000111967]

AlphaFold

D3YX43

Predicted Effect

probably benign
Transcript: ENSMUST00000086464
AA Change: M446L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000083655
Gene: ENSMUSG00000066894
AA Change: M446L

Domain	Start	End	E-Value	Type
low complexity region	2	16	N/A	INTRINSIC
IG	23	114	4.03e-8	SMART
IG	132	214	9.49e-5	SMART
Pfam:Ig_2	215	300	2.6e-2	PFAM
Pfam:Ig_3	216	284	3.5e-4	PFAM
IGc2	313	384	1.12e-6	SMART
transmembrane domain	403	425	N/A	INTRINSIC
coiled coil region	446	481	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111967
AA Change: M473L

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000107598
Gene: ENSMUSG00000066894
AA Change: M473L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IG	50	141	4.03e-8	SMART
IG	159	241	9.49e-5	SMART
Blast:IG_like	248	327	2e-33	BLAST
IGc2	340	411	1.12e-6	SMART
transmembrane domain	430	452	N/A	INTRINSIC
coiled coil region	473	508	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122416

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139026

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147182

SMART Domains

Protein: ENSMUSP00000125808
Gene: ENSMUSG00000066894

Domain	Start	End	E-Value	Type
Blast:IG_like	1	41	3e-14	BLAST
IGc2	54	125	1.12e-6	SMART
transmembrane domain	144	166	N/A	INTRINSIC
coiled coil region	187	222	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(11) : Gene trapped(11)

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts3	G	A	5: 89,849,525 (GRCm39)	H632Y	probably damaging	Het
Adgre5	T	A	8: 84,455,030 (GRCm39)	M221L	probably benign	Het
Apba2	A	T	7: 64,386,689 (GRCm39)	I439F	possibly damaging	Het
Arid1b	C	A	17: 5,371,559 (GRCm39)	N632K	probably damaging	Het
Bcas3	A	T	11: 85,256,417 (GRCm39)	I60L	probably damaging	Het
Brd9	T	C	13: 74,086,666 (GRCm39)	S56P	probably damaging	Het
Ccdc57	T	A	11: 120,751,295 (GRCm39)	D925V	possibly damaging	Het
Ccna1	A	G	3: 54,958,076 (GRCm39)	V143A	probably damaging	Het
Cdhr3	T	C	12: 33,102,208 (GRCm39)	T410A	probably benign	Het
Cimap3	A	G	3: 105,921,824 (GRCm39)	V33A	probably benign	Het
Ddx60	G	T	8: 62,411,680 (GRCm39)	D511Y	probably damaging	Het
Drc7	C	A	8: 95,782,629 (GRCm39)		probably benign	Het
Dysf	A	G	6: 84,118,933 (GRCm39)	E1290G	probably benign	Het
Fam168b	T	C	1: 34,875,883 (GRCm39)	M1V	probably null	Het
Farsa	A	G	8: 85,590,886 (GRCm39)	K208R	probably damaging	Het
Fnip2	A	G	3: 79,425,368 (GRCm39)		probably benign	Het
Gm17535	A	T	9: 3,035,111 (GRCm39)	H170L	probably benign	Het
Gm4553	T	C	7: 141,718,964 (GRCm39)	S155G	unknown	Het
Gm5852	T	C	3: 93,634,501 (GRCm39)		noncoding transcript	Het
Gnb2	T	C	5: 137,528,968 (GRCm39)		probably benign	Het
Gpr158	A	G	2: 21,373,494 (GRCm39)	N143S	probably damaging	Het
Hcn1	C	A	13: 117,739,513 (GRCm39)	Q92K	unknown	Het
Helb	T	C	10: 119,934,150 (GRCm39)	I678V	possibly damaging	Het
Hnrnpl	C	A	7: 28,512,798 (GRCm39)	A118D	probably damaging	Het
Klhl14	G	A	18: 21,784,921 (GRCm39)	P169S	probably benign	Het
Kndc1	T	C	7: 139,481,904 (GRCm39)		probably benign	Het
Lmod2	A	G	6: 24,598,051 (GRCm39)	E57G	probably damaging	Het
Lrch4	T	C	5: 137,636,009 (GRCm39)	I300T	possibly damaging	Het
Lrp6	A	G	6: 134,433,053 (GRCm39)	V1426A	probably benign	Het
Lrrc39	A	G	3: 116,364,630 (GRCm39)		probably benign	Het
Mamstr	G	A	7: 45,293,709 (GRCm39)	V262I	probably benign	Het
Mob1b	A	T	5: 88,904,014 (GRCm39)	T217S	probably benign	Het
Mocs3	G	A	2: 168,073,411 (GRCm39)	R286H	possibly damaging	Het
Mpo	A	T	11: 87,693,443 (GRCm39)	Q27L	probably benign	Het
Ncdn	A	T	4: 126,640,981 (GRCm39)	D506E	probably benign	Het
Noxa1	A	G	2: 24,984,914 (GRCm39)	I8T	probably benign	Het
Oma1	G	T	4: 103,176,565 (GRCm39)	A110S	probably benign	Het
Or10a48	C	T	7: 108,424,280 (GRCm39)	V309I	probably benign	Het
Or13a18	T	A	7: 140,190,666 (GRCm39)	S196T	probably damaging	Het
Or8b4	A	G	9: 37,830,346 (GRCm39)	Y131C	probably damaging	Het
Pde4a	A	C	9: 21,122,357 (GRCm39)	K694T	probably benign	Het
Phc1	A	G	6: 122,299,958 (GRCm39)		probably benign	Het
Pias1	A	G	9: 62,830,578 (GRCm39)	V187A	probably damaging	Het
Pigf	C	A	17: 87,327,876 (GRCm39)	L130F	probably null	Het
Pkd1	G	T	17: 24,799,069 (GRCm39)	V2763L	probably damaging	Het
Potefam1	G	T	2: 111,051,107 (GRCm39)	L230I	probably damaging	Het
Ppp1r8	T	C	4: 132,561,992 (GRCm39)	Y76C	probably damaging	Het
Ppp6r3	C	A	19: 3,568,324 (GRCm39)	G158V	probably damaging	Het
Ptpn13	A	G	5: 103,698,924 (GRCm39)	I1136V	probably damaging	Het
Ptprq	T	C	10: 107,412,790 (GRCm39)	I1770V	probably damaging	Het
Rhpn2	A	T	7: 35,070,185 (GRCm39)	I148F	probably damaging	Het
Stard3	T	C	11: 98,268,285 (GRCm39)	Y239H	probably damaging	Het
Stau1	T	C	2: 166,792,729 (GRCm39)	Y412C	probably benign	Het
Sucnr1	A	G	3: 59,994,053 (GRCm39)	I194V	probably benign	Het
Tanc1	A	G	2: 59,621,185 (GRCm39)	T335A	possibly damaging	Het
Tmem126a	T	C	7: 90,101,963 (GRCm39)	T79A	probably benign	Het
Trav9-2	A	T	14: 53,828,840 (GRCm39)	Y70F	probably benign	Het
Tspear	A	G	10: 77,709,070 (GRCm39)	E432G	probably benign	Het
Ube2o	T	C	11: 116,435,580 (GRCm39)	R403G	probably benign	Het
Unc80	C	A	1: 66,645,618 (GRCm39)	S1431R	possibly damaging	Het
Usp24	G	A	4: 106,258,336 (GRCm39)	C1578Y	probably damaging	Het
Xpot	T	A	10: 121,441,549 (GRCm39)	M559L	probably benign	Het

Other mutations in Vsig10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Vsig10	APN	5	117,476,479 (GRCm39)	missense	probably benign	0.00
IGL01082:Vsig10	APN	5	117,472,970 (GRCm39)	missense	probably benign	0.33
IGL01285:Vsig10	APN	5	117,462,954 (GRCm39)	missense	probably benign	0.43
IGL01790:Vsig10	APN	5	117,476,379 (GRCm39)	missense	probably damaging	1.00
IGL03004:Vsig10	APN	5	117,463,140 (GRCm39)	missense	probably damaging	1.00
D3080:Vsig10	UTSW	5	117,481,884 (GRCm39)	missense	probably damaging	1.00
R0101:Vsig10	UTSW	5	117,473,134 (GRCm39)	critical splice donor site	probably null
R0403:Vsig10	UTSW	5	117,476,526 (GRCm39)	missense	probably benign	0.05
R0674:Vsig10	UTSW	5	117,481,911 (GRCm39)	missense	probably damaging	1.00
R1437:Vsig10	UTSW	5	117,489,635 (GRCm39)	missense	probably damaging	0.96
R1689:Vsig10	UTSW	5	117,490,825 (GRCm39)	missense	probably benign	0.00
R1710:Vsig10	UTSW	5	117,489,719 (GRCm39)	missense	probably benign
R1765:Vsig10	UTSW	5	117,456,880 (GRCm39)	unclassified	probably benign
R4422:Vsig10	UTSW	5	117,462,986 (GRCm39)	missense	probably benign	0.00
R4541:Vsig10	UTSW	5	117,490,881 (GRCm39)	utr 3 prime	probably benign
R4909:Vsig10	UTSW	5	117,476,308 (GRCm39)	missense	probably benign	0.31
R4999:Vsig10	UTSW	5	117,482,040 (GRCm39)	missense	probably damaging	1.00
R5855:Vsig10	UTSW	5	117,476,335 (GRCm39)	missense	probably damaging	1.00
R5866:Vsig10	UTSW	5	117,490,814 (GRCm39)	critical splice acceptor site	probably null
R6214:Vsig10	UTSW	5	117,481,989 (GRCm39)	missense	probably damaging	1.00
R6418:Vsig10	UTSW	5	117,486,361 (GRCm39)	missense	probably benign	0.03
R6505:Vsig10	UTSW	5	117,489,824 (GRCm39)	missense	possibly damaging	0.95
R6854:Vsig10	UTSW	5	117,476,472 (GRCm39)	missense	probably benign	0.36
R7121:Vsig10	UTSW	5	117,481,967 (GRCm39)	missense	probably damaging	1.00
R7596:Vsig10	UTSW	5	117,472,848 (GRCm39)	missense	possibly damaging	0.46
R8066:Vsig10	UTSW	5	117,489,849 (GRCm39)	missense	probably benign	0.00
R8335:Vsig10	UTSW	5	117,486,435 (GRCm39)	missense	probably damaging	1.00
R8787:Vsig10	UTSW	5	117,472,981 (GRCm39)	missense	probably benign	0.18
R9026:Vsig10	UTSW	5	117,476,323 (GRCm39)	missense	probably benign	0.00
R9257:Vsig10	UTSW	5	117,463,131 (GRCm39)	missense	probably benign	0.29
R9386:Vsig10	UTSW	5	117,463,140 (GRCm39)	missense	probably damaging	1.00
R9474:Vsig10	UTSW	5	117,463,104 (GRCm39)	missense	probably benign	0.00

Posted On

2012-12-06