Incidental Mutation 'IGL00847:Zfp11'
ID14941
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp11
Ensembl Gene ENSMUSG00000051034
Gene Namezinc finger protein 11
SynonymsZfp-11, Krox-6
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.241) question?
Stock #IGL00847
Quality Score
Status
Chromosome5
Chromosomal Location129654593-129670099 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 129657914 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 161 (V161A)
Ref Sequence ENSEMBL: ENSMUSP00000051861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049778]
Predicted Effect probably benign
Transcript: ENSMUST00000049778
AA Change: V161A

PolyPhen 2 Score 0.165 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000051861
Gene: ENSMUSG00000051034
AA Change: V161A

DomainStartEndE-ValueType
ZnF_C2H2 57 79 1.03e-2 SMART
ZnF_C2H2 85 107 4.87e-4 SMART
ZnF_C2H2 113 135 2.91e-2 SMART
ZnF_C2H2 141 163 1.1e-2 SMART
ZnF_C2H2 169 191 4.47e-3 SMART
ZnF_C2H2 197 219 6.78e-3 SMART
ZnF_C2H2 225 247 3.39e-3 SMART
ZnF_C2H2 253 275 1.3e-4 SMART
ZnF_C2H2 281 303 8.34e-3 SMART
ZnF_C2H2 309 331 9.08e-4 SMART
ZnF_C2H2 337 359 7.37e-4 SMART
ZnF_C2H2 365 387 4.94e-5 SMART
ZnF_C2H2 393 415 9.58e-3 SMART
ZnF_C2H2 421 443 1.28e-3 SMART
ZnF_C2H2 449 471 6.32e-3 SMART
ZnF_C2H2 477 499 5.5e-3 SMART
ZnF_C2H2 505 527 4.17e-3 SMART
ZnF_C2H2 533 555 3.16e-3 SMART
ZnF_C2H2 561 583 1.45e-2 SMART
ZnF_C2H2 589 611 5.5e-3 SMART
ZnF_C2H2 617 639 1.58e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 T C 19: 57,152,290 E142G possibly damaging Het
Arid4a C T 12: 71,075,718 P958S probably damaging Het
BC049730 A G 7: 24,714,248 T230A probably benign Het
Cct5 T C 15: 31,590,927 probably benign Het
Cntnap4 C T 8: 112,767,619 probably benign Het
Col4a3 C T 1: 82,717,869 L1597F probably damaging Het
Gla C A X: 134,595,198 V179L probably benign Het
Gm20422 A T 8: 69,742,992 C212* probably null Het
Hace1 T A 10: 45,672,357 Y14* probably null Het
Hcfc2 T A 10: 82,741,278 probably null Het
Helz2 T C 2: 181,232,245 D2152G possibly damaging Het
Mcm8 T G 2: 132,819,674 L74V probably benign Het
Myo18b A G 5: 112,830,389 probably benign Het
Ptprg A T 14: 12,215,265 N1084I probably damaging Het
Rad21l C A 2: 151,660,715 A192S probably benign Het
Scn2a A G 2: 65,670,734 D80G probably damaging Het
Serpinb3c A G 1: 107,276,260 probably null Het
Sgip1 A G 4: 102,928,921 probably benign Het
Slc25a41 G T 17: 57,034,957 probably null Het
Snx14 C A 9: 88,420,329 R140S probably damaging Het
Svs6 A C 2: 164,317,587 K90T possibly damaging Het
Tlcd1 T A 11: 78,180,088 Y168N probably damaging Het
Vps13d A G 4: 145,085,408 I3312T probably benign Het
Other mutations in Zfp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0190:Zfp11 UTSW 5 129658238 missense possibly damaging 0.88
R0239:Zfp11 UTSW 5 129658238 missense possibly damaging 0.88
R0239:Zfp11 UTSW 5 129658238 missense possibly damaging 0.88
R0419:Zfp11 UTSW 5 129658238 missense possibly damaging 0.88
R0423:Zfp11 UTSW 5 129658238 missense possibly damaging 0.88
R0601:Zfp11 UTSW 5 129657907 missense probably damaging 1.00
R0731:Zfp11 UTSW 5 129657264 missense probably damaging 1.00
R0826:Zfp11 UTSW 5 129657525 missense probably benign 0.04
R1467:Zfp11 UTSW 5 129658190 missense probably benign 0.01
R1467:Zfp11 UTSW 5 129658190 missense probably benign 0.01
R1613:Zfp11 UTSW 5 129658367 missense probably benign 0.09
R1711:Zfp11 UTSW 5 129656673 missense probably benign 0.03
R1770:Zfp11 UTSW 5 129657758 missense possibly damaging 0.94
R2155:Zfp11 UTSW 5 129657152 missense probably damaging 1.00
R2369:Zfp11 UTSW 5 129656465 missense probably benign 0.40
R5597:Zfp11 UTSW 5 129657102 missense probably benign 0.08
R5902:Zfp11 UTSW 5 129657912 missense probably damaging 0.98
R6324:Zfp11 UTSW 5 129656523 missense possibly damaging 0.95
R6768:Zfp11 UTSW 5 129658351 missense probably benign 0.05
R6943:Zfp11 UTSW 5 129658088 missense probably damaging 0.99
Posted On2012-12-06