Incidental Mutation 'IGL00847:Zfp11'
| ID |
14941 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp11
|
| Ensembl Gene |
ENSMUSG00000051034 |
| Gene Name |
zinc finger protein 11 |
| Synonyms |
Zfp-11, Krox-6 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
IGL00847
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
129731659-129747152 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 129734978 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 161
(V161A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000051861
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049778]
|
| AlphaFold |
P10751 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049778
AA Change: V161A
PolyPhen 2
Score 0.165 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000051861
Gene: ENSMUSG00000051034
AA Change: V161A
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
57 |
79 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
85 |
107 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
113 |
135 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
141 |
163 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
169 |
191 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
197 |
219 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
225 |
247 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
281 |
303 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
309 |
331 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
337 |
359 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
365 |
387 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
393 |
415 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
449 |
471 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
477 |
499 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
505 |
527 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
533 |
555 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
561 |
583 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
589 |
611 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
617 |
639 |
1.58e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 23 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim1 |
T |
C |
19: 57,140,722 (GRCm39) |
E142G |
possibly damaging |
Het |
| Arid4a |
C |
T |
12: 71,122,492 (GRCm39) |
P958S |
probably damaging |
Het |
| Cct5 |
T |
C |
15: 31,591,073 (GRCm39) |
|
probably benign |
Het |
| Cntnap4 |
C |
T |
8: 113,494,251 (GRCm39) |
|
probably benign |
Het |
| Col4a3 |
C |
T |
1: 82,695,590 (GRCm39) |
L1597F |
probably damaging |
Het |
| Gla |
C |
A |
X: 133,495,947 (GRCm39) |
V179L |
probably benign |
Het |
| Gm20422 |
A |
T |
8: 70,195,642 (GRCm39) |
C212* |
probably null |
Het |
| Hace1 |
T |
A |
10: 45,548,453 (GRCm39) |
Y14* |
probably null |
Het |
| Hcfc2 |
T |
A |
10: 82,577,112 (GRCm39) |
|
probably null |
Het |
| Helz2 |
T |
C |
2: 180,874,038 (GRCm39) |
D2152G |
possibly damaging |
Het |
| Lypd10 |
A |
G |
7: 24,413,673 (GRCm39) |
T230A |
probably benign |
Het |
| Mcm8 |
T |
G |
2: 132,661,594 (GRCm39) |
L74V |
probably benign |
Het |
| Myo18b |
A |
G |
5: 112,978,255 (GRCm39) |
|
probably benign |
Het |
| Ptprg |
A |
T |
14: 12,215,265 (GRCm38) |
N1084I |
probably damaging |
Het |
| Rad21l |
C |
A |
2: 151,502,635 (GRCm39) |
A192S |
probably benign |
Het |
| Scn2a |
A |
G |
2: 65,501,078 (GRCm39) |
D80G |
probably damaging |
Het |
| Serpinb3c |
A |
G |
1: 107,203,990 (GRCm39) |
|
probably null |
Het |
| Sgip1 |
A |
G |
4: 102,786,118 (GRCm39) |
|
probably benign |
Het |
| Slc25a41 |
G |
T |
17: 57,341,957 (GRCm39) |
|
probably null |
Het |
| Snx14 |
C |
A |
9: 88,302,382 (GRCm39) |
R140S |
probably damaging |
Het |
| Svs6 |
A |
C |
2: 164,159,507 (GRCm39) |
K90T |
possibly damaging |
Het |
| Tlcd1 |
T |
A |
11: 78,070,914 (GRCm39) |
Y168N |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,811,978 (GRCm39) |
I3312T |
probably benign |
Het |
|
| Other mutations in Zfp11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0190:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0239:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0239:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0419:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0423:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0601:Zfp11
|
UTSW |
5 |
129,734,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0731:Zfp11
|
UTSW |
5 |
129,734,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Zfp11
|
UTSW |
5 |
129,734,589 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Zfp11
|
UTSW |
5 |
129,735,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Zfp11
|
UTSW |
5 |
129,735,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1613:Zfp11
|
UTSW |
5 |
129,735,431 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1711:Zfp11
|
UTSW |
5 |
129,733,737 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1770:Zfp11
|
UTSW |
5 |
129,734,822 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2155:Zfp11
|
UTSW |
5 |
129,734,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2369:Zfp11
|
UTSW |
5 |
129,733,529 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5597:Zfp11
|
UTSW |
5 |
129,734,166 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5902:Zfp11
|
UTSW |
5 |
129,734,976 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Zfp11
|
UTSW |
5 |
129,733,587 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6768:Zfp11
|
UTSW |
5 |
129,735,415 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6943:Zfp11
|
UTSW |
5 |
129,735,152 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7782:Zfp11
|
UTSW |
5 |
129,734,027 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8144:Zfp11
|
UTSW |
5 |
129,733,694 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8813:Zfp11
|
UTSW |
5 |
129,735,278 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8980:Zfp11
|
UTSW |
5 |
129,737,843 (GRCm39) |
start codon destroyed |
probably benign |
0.05 |
|
R9173:Zfp11
|
UTSW |
5 |
129,734,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Zfp11
|
UTSW |
5 |
129,734,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Zfp11
|
UTSW |
5 |
129,734,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2012-12-06 |
Incidental Mutation