Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00720:Zscan26'

14949

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zscan26

Ensembl Gene

ENSMUSG00000022228

Gene Name

zinc finger and SCAN domain containing 26

Synonyms

Zfp187

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.145) question?

Stock #

IGL00720

Quality Score

Status

Chromosome

Chromosomal Location

21626350-21637900 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 21629369 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 378 (R378H)

Ref Sequence

ENSEMBL: ENSMUSP00000106111 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032820] [ENSMUST00000099719] [ENSMUST00000110485] [ENSMUST00000122872] [ENSMUST00000145494] [ENSMUST00000151743] [ENSMUST00000148071]

AlphaFold

Q5RJ54

Predicted Effect

probably benign
Transcript: ENSMUST00000032820
AA Change: R252H

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000032820
Gene: ENSMUSG00000022228
AA Change: R252H

Domain	Start	End	E-Value	Type
ZnF_C2H2	144	166	1.58e-3	SMART
ZnF_C2H2	172	194	6.99e-5	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	228	250	1.45e-2	SMART
ZnF_C2H2	256	278	2.53e-2	SMART
ZnF_C2H2	284	306	5.14e-3	SMART
ZnF_C2H2	312	334	2.95e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000099719

SMART Domains

Protein: ENSMUSP00000097307
Gene: ENSMUSG00000055313

Domain	Start	End	E-Value	Type
Blast:SCAN	1	65	7e-14	BLAST
low complexity region	192	204	N/A	INTRINSIC
Pfam:DDE_Tnp_1_7	250	411	1.1e-45	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000110485
AA Change: R378H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000106111
Gene: ENSMUSG00000022228
AA Change: R378H

Domain	Start	End	E-Value	Type
SCAN	38	151	1.58e-48	SMART
ZnF_C2H2	270	292	1.58e-3	SMART
ZnF_C2H2	298	320	6.99e-5	SMART
ZnF_C2H2	326	348	1.67e-2	SMART
ZnF_C2H2	354	376	1.45e-2	SMART
ZnF_C2H2	382	404	2.53e-2	SMART
ZnF_C2H2	410	432	5.14e-3	SMART
ZnF_C2H2	438	460	2.95e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122641

Predicted Effect

probably benign
Transcript: ENSMUST00000122872

SMART Domains

Protein: ENSMUSP00000120175
Gene: ENSMUSG00000055313

Domain	Start	End	E-Value	Type
Blast:SCAN	1	65	1e-13	BLAST
low complexity region	155	167	N/A	INTRINSIC
Pfam:DDE_Tnp_1_7	213	374	1.4e-42	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122926

Predicted Effect

probably benign
Transcript: ENSMUST00000145494

SMART Domains

Protein: ENSMUSP00000118503
Gene: ENSMUSG00000055313

Domain	Start	End	E-Value	Type
Blast:SCAN	1	65	8e-15	BLAST
low complexity region	192	204	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000151743

SMART Domains

Protein: ENSMUSP00000117669
Gene: ENSMUSG00000055313

Domain	Start	End	E-Value	Type
Blast:SCAN	1	65	7e-14	BLAST
low complexity region	192	204	N/A	INTRINSIC
Pfam:DDE_Tnp_1_7	250	411	1.7e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000148071

SMART Domains

Protein: ENSMUSP00000114882
Gene: ENSMUSG00000055313

Domain	Start	End	E-Value	Type
Blast:SCAN	1	65	3e-16	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 11 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cul4a	A	G	8: 13,177,735 (GRCm39)	K292E	probably benign	Het
Fat2	T	C	11: 55,202,070 (GRCm39)	T335A	probably benign	Het
Hrh2	T	C	13: 54,368,840 (GRCm39)	V272A	possibly damaging	Het
Jak3	A	G	8: 72,136,681 (GRCm39)	I663V	probably damaging	Het
Kifc3	A	G	8: 95,864,644 (GRCm39)	V22A	probably damaging	Het
Nat8f1	A	G	6: 85,887,957 (GRCm39)	M1T	probably null	Het
Scn7a	A	T	2: 66,506,388 (GRCm39)	S1500R	possibly damaging	Het
Stambp	A	T	6: 83,547,419 (GRCm39)	S23R	probably damaging	Het
Tenm3	T	C	8: 48,729,456 (GRCm39)	N1517D	probably damaging	Het
Zfp663	A	T	2: 165,194,525 (GRCm39)	F565I	probably damaging	Het
Zng1	T	C	19: 24,898,495 (GRCm39)	D321G	probably benign	Het

Other mutations in Zscan26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00503:Zscan26	APN	13	21,629,271 (GRCm39)	missense	probably damaging	0.99
R0558:Zscan26	UTSW	13	21,629,225 (GRCm39)	missense	probably benign	0.37
R1236:Zscan26	UTSW	13	21,629,940 (GRCm39)	missense	probably benign
R1912:Zscan26	UTSW	13	21,629,310 (GRCm39)	missense	possibly damaging	0.84
R4692:Zscan26	UTSW	13	21,629,427 (GRCm39)	missense	probably damaging	1.00
R5818:Zscan26	UTSW	13	21,629,931 (GRCm39)	missense	probably benign	0.00
R6089:Zscan26	UTSW	13	21,632,499 (GRCm39)	missense	probably damaging	0.97
R8029:Zscan26	UTSW	13	21,629,520 (GRCm39)	missense	probably damaging	1.00
R9448:Zscan26	UTSW	13	21,632,431 (GRCm39)	missense	probably benign
Z1088:Zscan26	UTSW	13	21,629,633 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06