Incidental Mutation 'IGL00733:Zfp229'
ID 14953
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp229
Ensembl Gene ENSMUSG00000061544
Gene Name zinc finger protein 229
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # IGL00733
Quality Score
Status
Chromosome 17
Chromosomal Location 21949936-21967950 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 21958483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 7 (N7I)
Ref Sequence ENSEMBL: ENSMUSP00000138107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065871] [ENSMUST00000182603] [ENSMUST00000182827] [ENSMUST00000183192]
AlphaFold E9PWT2
Predicted Effect possibly damaging
Transcript: ENSMUST00000065871
AA Change: N7I

PolyPhen 2 Score 0.517 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000065379
Gene: ENSMUSG00000061544
AA Change: N7I

DomainStartEndE-ValueType
KRAB 13 73 7.74e-30 SMART
ZnF_C2H2 229 249 1.88e2 SMART
ZnF_C2H2 257 279 1.38e-3 SMART
ZnF_C2H2 285 307 3.63e-3 SMART
ZnF_C2H2 312 334 9.44e-2 SMART
ZnF_C2H2 340 362 3.58e-2 SMART
ZnF_C2H2 368 390 2.99e-4 SMART
ZnF_C2H2 395 417 2.36e-2 SMART
ZnF_C2H2 423 445 2.09e-3 SMART
ZnF_C2H2 451 473 1.18e-2 SMART
ZnF_C2H2 479 501 6.78e-3 SMART
ZnF_C2H2 507 529 1.28e-3 SMART
ZnF_C2H2 535 557 7.05e-1 SMART
ZnF_C2H2 562 584 8.02e-5 SMART
ZnF_C2H2 590 612 9.58e-3 SMART
ZnF_C2H2 618 640 7.78e-3 SMART
ZnF_C2H2 646 668 3.83e-2 SMART
ZnF_C2H2 674 696 1.72e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182334
Predicted Effect possibly damaging
Transcript: ENSMUST00000182603
AA Change: N7I

PolyPhen 2 Score 0.517 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000138107
Gene: ENSMUSG00000061544
AA Change: N7I

DomainStartEndE-ValueType
KRAB 13 73 7.74e-30 SMART
Pfam:zf-C2H2_6 205 219 3.9e-1 PFAM
ZnF_C2H2 229 249 1.88e2 SMART
ZnF_C2H2 257 279 1.38e-3 SMART
ZnF_C2H2 285 307 3.63e-3 SMART
ZnF_C2H2 312 334 9.44e-2 SMART
ZnF_C2H2 340 362 3.58e-2 SMART
ZnF_C2H2 368 390 2.99e-4 SMART
ZnF_C2H2 395 417 2.36e-2 SMART
ZnF_C2H2 423 445 2.09e-3 SMART
ZnF_C2H2 451 473 1.18e-2 SMART
ZnF_C2H2 479 501 6.78e-3 SMART
ZnF_C2H2 507 529 1.28e-3 SMART
ZnF_C2H2 535 557 7.05e-1 SMART
ZnF_C2H2 562 584 8.02e-5 SMART
ZnF_C2H2 590 612 9.58e-3 SMART
ZnF_C2H2 618 640 7.78e-3 SMART
ZnF_C2H2 646 668 3.83e-2 SMART
ZnF_C2H2 674 696 1.72e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000182827
AA Change: N7I

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000138478
Gene: ENSMUSG00000061544
AA Change: N7I

DomainStartEndE-ValueType
KRAB 13 73 7.74e-30 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182923
Predicted Effect probably benign
Transcript: ENSMUST00000183192
AA Change: N7I

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000138265
Gene: ENSMUSG00000061544
AA Change: N7I

DomainStartEndE-ValueType
KRAB 13 73 7.74e-30 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 7 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bmp8b A T 4: 123,018,202 (GRCm39) I358F probably benign Het
Clstn2 A G 9: 97,365,102 (GRCm39) V468A probably damaging Het
Ets1 T A 9: 32,664,222 (GRCm39) probably benign Het
Kcnj15 G A 16: 95,097,322 (GRCm39) E315K probably damaging Het
Lmo7 T A 14: 102,153,138 (GRCm39) S950T probably damaging Het
Nlrp12 T C 7: 3,289,387 (GRCm39) Y375C probably damaging Het
Snx29 C T 16: 11,221,366 (GRCm39) T264I probably damaging Het
Other mutations in Zfp229
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0268:Zfp229 UTSW 17 21,964,822 (GRCm39) missense probably benign
R0344:Zfp229 UTSW 17 21,964,822 (GRCm39) missense probably benign
R0608:Zfp229 UTSW 17 21,965,615 (GRCm39) missense probably damaging 1.00
R1672:Zfp229 UTSW 17 21,964,828 (GRCm39) missense probably damaging 1.00
R2215:Zfp229 UTSW 17 21,965,258 (GRCm39) missense possibly damaging 0.90
R2519:Zfp229 UTSW 17 21,964,568 (GRCm39) missense possibly damaging 0.89
R2937:Zfp229 UTSW 17 21,964,484 (GRCm39) missense probably damaging 1.00
R2965:Zfp229 UTSW 17 21,965,010 (GRCm39) missense probably damaging 1.00
R3108:Zfp229 UTSW 17 21,965,797 (GRCm39) missense probably damaging 1.00
R3768:Zfp229 UTSW 17 21,964,844 (GRCm39) missense probably damaging 1.00
R3778:Zfp229 UTSW 17 21,964,183 (GRCm39) missense probably benign 0.44
R3850:Zfp229 UTSW 17 21,964,843 (GRCm39) missense probably damaging 1.00
R4273:Zfp229 UTSW 17 21,965,802 (GRCm39) missense probably benign 0.02
R4731:Zfp229 UTSW 17 21,964,267 (GRCm39) missense possibly damaging 0.73
R4732:Zfp229 UTSW 17 21,964,267 (GRCm39) missense possibly damaging 0.73
R4733:Zfp229 UTSW 17 21,964,267 (GRCm39) missense possibly damaging 0.73
R4818:Zfp229 UTSW 17 21,962,885 (GRCm39) missense probably benign 0.33
R4929:Zfp229 UTSW 17 21,965,354 (GRCm39) missense probably damaging 1.00
R5512:Zfp229 UTSW 17 21,964,017 (GRCm39) splice site probably null
R7124:Zfp229 UTSW 17 21,961,597 (GRCm39) missense probably damaging 0.98
R7511:Zfp229 UTSW 17 21,964,045 (GRCm39) missense probably benign 0.00
R7576:Zfp229 UTSW 17 21,964,280 (GRCm39) missense probably damaging 1.00
R7840:Zfp229 UTSW 17 21,965,131 (GRCm39) nonsense probably null
R8396:Zfp229 UTSW 17 21,965,077 (GRCm39) missense probably damaging 1.00
R8427:Zfp229 UTSW 17 21,965,815 (GRCm39) missense probably damaging 1.00
R8725:Zfp229 UTSW 17 21,964,828 (GRCm39) missense probably damaging 1.00
R8727:Zfp229 UTSW 17 21,964,828 (GRCm39) missense probably damaging 1.00
R8770:Zfp229 UTSW 17 21,964,795 (GRCm39) missense probably damaging 1.00
R9005:Zfp229 UTSW 17 21,965,731 (GRCm39) missense possibly damaging 0.86
R9029:Zfp229 UTSW 17 21,964,321 (GRCm39) missense possibly damaging 0.93
R9162:Zfp229 UTSW 17 21,964,495 (GRCm39) missense probably damaging 1.00
R9569:Zfp229 UTSW 17 21,964,573 (GRCm39) missense possibly damaging 0.78
R9726:Zfp229 UTSW 17 21,965,354 (GRCm39) missense probably damaging 1.00
R9760:Zfp229 UTSW 17 21,965,275 (GRCm39) missense probably damaging 1.00
Z1177:Zfp229 UTSW 17 21,962,923 (GRCm39) missense probably benign 0.00
Posted On 2012-12-06