Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00743:Zfp455'

14974

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp455

Ensembl Gene

ENSMUSG00000051037

Gene Name

zinc finger protein 455

Synonyms

Rslcan-10, 3732412P20Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.356) question?

Stock #

IGL00743

Quality Score

Status

Chromosome

Chromosomal Location

67342570-67357362 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 67355962 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 345 (I345T)

Ref Sequence

ENSEMBL: ENSMUSP00000113356 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117110] [ENSMUST00000120861]

AlphaFold

Q7M6X9

Predicted Effect

probably benign
Transcript: ENSMUST00000117110
AA Change: I345T

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000113356
Gene: ENSMUSG00000051037
AA Change: I345T

Domain	Start	End	E-Value	Type
ZnF_C2H2	44	66	7.15e-2	SMART
ZnF_C2H2	72	94	1.6e-4	SMART
ZnF_C2H2	100	122	2.12e-4	SMART
ZnF_C2H2	128	150	6.23e-2	SMART
ZnF_C2H2	184	206	1.01e-1	SMART
ZnF_C2H2	212	234	3.11e-2	SMART
ZnF_C2H2	240	262	1.1e-2	SMART
ZnF_C2H2	268	290	1.38e-3	SMART
ZnF_C2H2	296	318	3.58e-2	SMART
ZnF_C2H2	324	346	2.24e-3	SMART
ZnF_C2H2	352	374	7.9e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000120861
AA Change: I410T

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000112546
Gene: ENSMUSG00000051037
AA Change: I410T

Domain	Start	End	E-Value	Type
KRAB	5	65	1.92e-34	SMART
ZnF_C2H2	109	131	7.15e-2	SMART
ZnF_C2H2	137	159	1.6e-4	SMART
ZnF_C2H2	165	187	2.12e-4	SMART
ZnF_C2H2	193	215	6.23e-2	SMART
ZnF_C2H2	249	271	1.01e-1	SMART
ZnF_C2H2	277	299	3.11e-2	SMART
ZnF_C2H2	305	327	1.1e-2	SMART
ZnF_C2H2	333	355	1.38e-3	SMART
ZnF_C2H2	361	383	3.58e-2	SMART
ZnF_C2H2	389	411	2.24e-3	SMART
ZnF_C2H2	417	439	7.9e-4	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss1	T	C	2: 150,461,606 (GRCm39)	E659G	probably benign	Het
Adgrg6	A	C	10: 14,411,703 (GRCm39)		probably benign	Het
Als2cl	A	G	9: 110,718,227 (GRCm39)	K323E	possibly damaging	Het
Atm	A	C	9: 53,424,416 (GRCm39)	S628R	probably benign	Het
Baz2a	T	C	10: 127,950,395 (GRCm39)	V443A	probably benign	Het
Bclaf3	T	A	X: 158,341,357 (GRCm39)	F545Y	probably benign	Het
Calcr	T	C	6: 3,717,196 (GRCm39)	Y88C	probably damaging	Het
Ccdc178	C	T	18: 22,278,501 (GRCm39)		probably benign	Het
Cdh20	A	G	1: 104,875,153 (GRCm39)	T312A	probably benign	Het
Chrnd	G	A	1: 87,120,649 (GRCm39)	W91*	probably null	Het
Cntln	T	C	4: 84,897,652 (GRCm39)	F413S	probably benign	Het
Ctsq	A	T	13: 61,183,998 (GRCm39)	I308N	probably damaging	Het
Cyp2d34	A	T	15: 82,501,736 (GRCm39)	V258D	probably damaging	Het
Dnajc13	G	A	9: 104,039,979 (GRCm39)	P2044S	probably benign	Het
Hnrnpm	C	A	17: 33,868,876 (GRCm39)	R517L	probably damaging	Het
Hps6	A	T	19: 45,992,099 (GRCm39)	D12V	probably damaging	Het
Hpse	T	C	5: 100,846,865 (GRCm39)	D188G	probably benign	Het
Id2	C	A	12: 25,145,355 (GRCm39)	E123*	probably null	Het
Ints10	C	T	8: 69,271,985 (GRCm39)	P562L	probably damaging	Het
Kctd10	G	A	5: 114,505,410 (GRCm39)	R195C	probably damaging	Het
Kel	A	C	6: 41,665,509 (GRCm39)	L537R	probably damaging	Het
Kif19a	T	C	11: 114,675,599 (GRCm39)	V357A	probably damaging	Het
Lrrtm3	A	T	10: 63,924,988 (GRCm39)	S60T	probably damaging	Het
Myof	C	A	19: 37,949,382 (GRCm39)	R608L	probably benign	Het
Naa35	A	T	13: 59,778,485 (GRCm39)	I669F	probably benign	Het
Or8g2b	A	T	9: 39,751,002 (GRCm39)	I91F	probably benign	Het
Or8g53	A	G	9: 39,683,407 (GRCm39)	S230P	possibly damaging	Het
Pclo	G	T	5: 14,728,035 (GRCm39)		probably benign	Het
Pik3c3	C	T	18: 30,407,417 (GRCm39)	S55F	probably damaging	Het
Prdm6	T	G	18: 53,673,300 (GRCm39)	D153E	possibly damaging	Het
Rnf183	T	C	4: 62,346,610 (GRCm39)	T63A	probably benign	Het
Samd4b	A	C	7: 28,101,302 (GRCm39)	I108S	probably damaging	Het
Slc9a7	T	C	X: 19,972,260 (GRCm39)	D708G	possibly damaging	Het
Stim2	A	G	5: 54,210,835 (GRCm39)	D90G	probably benign	Het
Tmem52b	A	G	6: 129,493,678 (GRCm39)	D97G	probably damaging	Het
Tnfsf15	T	C	4: 63,652,518 (GRCm39)	R98G	probably benign	Het
Uxs1	C	T	1: 43,796,173 (GRCm39)	V310I	probably benign	Het
Vcan	A	C	13: 89,873,425 (GRCm39)	M143R	probably damaging	Het
Vmn2r93	T	C	17: 18,546,504 (GRCm39)	F792S	probably damaging	Het
Zfp938	A	T	10: 82,062,317 (GRCm39)	M101K	probably benign	Het
Zkscan2	A	G	7: 123,079,195 (GRCm39)	S921P	probably damaging	Het

Other mutations in Zfp455

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03111:Zfp455	APN	13	67,356,063 (GRCm39)	missense	probably benign	0.00
IGL03210:Zfp455	APN	13	67,355,113 (GRCm39)	missense	possibly damaging	0.93
IGL03371:Zfp455	APN	13	67,355,066 (GRCm39)	nonsense	probably null
PIT4504001:Zfp455	UTSW	13	67,346,685 (GRCm39)	missense	probably damaging	0.98
R0245:Zfp455	UTSW	13	67,355,899 (GRCm39)	missense	probably damaging	1.00
R0277:Zfp455	UTSW	13	67,346,728 (GRCm39)	splice site	probably null
R1141:Zfp455	UTSW	13	67,346,655 (GRCm39)	missense	probably damaging	1.00
R1266:Zfp455	UTSW	13	67,355,028 (GRCm39)	nonsense	probably null
R1657:Zfp455	UTSW	13	67,346,703 (GRCm39)	missense	possibly damaging	0.83
R1749:Zfp455	UTSW	13	67,355,073 (GRCm39)	missense	probably damaging	1.00
R1757:Zfp455	UTSW	13	67,355,601 (GRCm39)	missense	probably damaging	1.00
R1854:Zfp455	UTSW	13	67,355,881 (GRCm39)	missense	probably damaging	1.00
R1867:Zfp455	UTSW	13	67,355,509 (GRCm39)	missense	probably benign	0.33
R4411:Zfp455	UTSW	13	67,355,389 (GRCm39)	missense	probably damaging	0.96
R6060:Zfp455	UTSW	13	67,355,257 (GRCm39)	missense	probably damaging	1.00
R6544:Zfp455	UTSW	13	67,355,121 (GRCm39)	missense	probably benign	0.33
R7132:Zfp455	UTSW	13	67,347,230 (GRCm39)	missense	probably damaging	1.00
R7524:Zfp455	UTSW	13	67,355,688 (GRCm39)	missense	possibly damaging	0.73
R7966:Zfp455	UTSW	13	67,347,302 (GRCm39)	missense	probably benign
R8848:Zfp455	UTSW	13	67,356,089 (GRCm39)	missense	possibly damaging	0.70
R8994:Zfp455	UTSW	13	67,355,478 (GRCm39)	missense	probably damaging	1.00
Z1176:Zfp455	UTSW	13	67,355,107 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-12-06