Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00715:Zfp507'

14976

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp507

Ensembl Gene

ENSMUSG00000044452

Gene Name

zinc finger protein 507

Synonyms

A230056M16Rik, 1810022O10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.190) question?

Stock #

IGL00715

Quality Score

Status

Chromosome

Chromosomal Location

35471768-35502428 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 35494137 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 302 (E302G)

Ref Sequence

ENSEMBL: ENSMUSP00000058609 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061586] [ENSMUST00000187282] [ENSMUST00000205670] [ENSMUST00000206615]

AlphaFold

Q6ZPY5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000061586
AA Change: E302G

PolyPhen 2 Score 0.927 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000058609
Gene: ENSMUSG00000044452
AA Change: E302G

Domain	Start	End	E-Value	Type
ZnF_C2H2	122	144	1.56e-2	SMART
ZnF_C2H2	152	175	2.49e-1	SMART
low complexity region	178	192	N/A	INTRINSIC
ZnF_C2H2	237	259	8.52e0	SMART
ZnF_C2H2	630	652	2.75e-3	SMART
ZnF_C2H2	658	680	1.26e-2	SMART
ZnF_C2H2	686	709	5.42e-2	SMART
ZnF_C2H2	746	768	4.79e-3	SMART
ZnF_C2H2	774	796	1.45e-2	SMART
ZnF_C2H2	899	921	3.83e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000187282

SMART Domains

Protein: ENSMUSP00000140940
Gene: ENSMUSG00000044452

Domain	Start	End	E-Value	Type
ZnF_C2H2	107	129	1.6e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205670

Predicted Effect

probably benign
Transcript: ENSMUST00000206615

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actr3	C	T	1: 125,322,813 (GRCm39)	A385T	probably damaging	Het
Cdh17	A	T	4: 11,797,780 (GRCm39)		probably benign	Het
Cntnap1	C	T	11: 101,074,031 (GRCm39)		probably benign	Het
Dhrs7	T	A	12: 72,699,164 (GRCm39)	M296L	probably damaging	Het
Fmo2	T	A	1: 162,716,282 (GRCm39)	K102*	probably null	Het
Foxn3	T	C	12: 99,162,866 (GRCm39)	E345G	possibly damaging	Het
Gabrg1	A	G	5: 70,973,298 (GRCm39)		probably null	Het
Gp1ba	A	C	11: 70,530,744 (GRCm39)		probably benign	Het
Grwd1	A	G	7: 45,480,037 (GRCm39)	Y57H	probably damaging	Het
Hars2	G	A	18: 36,918,989 (GRCm39)	C83Y	probably damaging	Het
Il5ra	C	T	6: 106,689,435 (GRCm39)		probably benign	Het
Itpr3	T	C	17: 27,302,603 (GRCm39)	V87A	probably benign	Het
Lrig2	A	G	3: 104,371,264 (GRCm39)	V455A	probably damaging	Het
P2ry10	T	A	X: 106,146,189 (GRCm39)	S41R	probably damaging	Het
Plcb2	C	T	2: 118,544,215 (GRCm39)		probably null	Het
Plod2	G	A	9: 92,480,667 (GRCm39)	R420H	probably damaging	Het
Prkcd	T	C	14: 30,317,960 (GRCm39)	N656S	probably damaging	Het
Serpinb6a	A	G	13: 34,115,495 (GRCm39)	F42S	possibly damaging	Het
Sis	A	G	3: 72,841,457 (GRCm39)	I786T	probably damaging	Het
Slc5a11	C	T	7: 122,849,397 (GRCm39)	A194V	probably null	Het
Spo11	T	C	2: 172,830,825 (GRCm39)		probably null	Het
Trap1a	A	G	X: 138,234,983 (GRCm39)	D94G	unknown	Het
Urb1	A	G	16: 90,550,209 (GRCm39)		probably null	Het
Usp1	T	C	4: 98,822,818 (GRCm39)		probably null	Het
Zfp300	T	C	X: 20,950,493 (GRCm39)	D34G	probably damaging	Het

Other mutations in Zfp507

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00835:Zfp507	APN	7	35,475,463 (GRCm39)	missense	probably damaging	1.00
IGL01083:Zfp507	APN	7	35,493,463 (GRCm39)	missense	probably benign	0.00
IGL01359:Zfp507	APN	7	35,493,927 (GRCm39)	missense	probably damaging	1.00
IGL01418:Zfp507	APN	7	35,493,237 (GRCm39)	splice site	probably null
IGL02122:Zfp507	APN	7	35,475,520 (GRCm39)	missense	probably damaging	1.00
IGL02506:Zfp507	APN	7	35,475,891 (GRCm39)	missense	probably damaging	1.00
IGL02601:Zfp507	APN	7	35,491,136 (GRCm39)	missense	probably damaging	1.00
IGL02643:Zfp507	APN	7	35,494,656 (GRCm39)	missense	probably damaging	0.99
IGL03129:Zfp507	APN	7	35,493,631 (GRCm39)	missense	probably damaging	1.00
R0400:Zfp507	UTSW	7	35,491,171 (GRCm39)	missense	probably damaging	1.00
R0812:Zfp507	UTSW	7	35,502,048 (GRCm39)	intron	probably benign
R1183:Zfp507	UTSW	7	35,494,315 (GRCm39)	missense	probably damaging	0.99
R1381:Zfp507	UTSW	7	35,475,435 (GRCm39)	missense	possibly damaging	0.91
R1542:Zfp507	UTSW	7	35,494,226 (GRCm39)	missense	possibly damaging	0.71
R1626:Zfp507	UTSW	7	35,494,858 (GRCm39)	missense	probably damaging	1.00
R1759:Zfp507	UTSW	7	35,475,403 (GRCm39)	missense	probably damaging	0.99
R1843:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1852:Zfp507	UTSW	7	35,487,176 (GRCm39)	missense	probably damaging	1.00
R1893:Zfp507	UTSW	7	35,502,052 (GRCm39)	intron	probably benign
R1923:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1925:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R1927:Zfp507	UTSW	7	35,493,150 (GRCm39)	missense	probably damaging	0.97
R2139:Zfp507	UTSW	7	35,493,148 (GRCm39)	missense	probably damaging	1.00
R2191:Zfp507	UTSW	7	35,494,268 (GRCm39)	missense	probably damaging	1.00
R2431:Zfp507	UTSW	7	35,494,827 (GRCm39)	missense	probably benign	0.08
R2921:Zfp507	UTSW	7	35,494,224 (GRCm39)	missense	probably damaging	1.00
R2922:Zfp507	UTSW	7	35,494,224 (GRCm39)	missense	probably damaging	1.00
R3436:Zfp507	UTSW	7	35,487,195 (GRCm39)	missense	probably damaging	1.00
R4483:Zfp507	UTSW	7	35,487,141 (GRCm39)	critical splice donor site	probably null
R4751:Zfp507	UTSW	7	35,493,807 (GRCm39)	missense	probably damaging	0.99
R4852:Zfp507	UTSW	7	35,493,480 (GRCm39)	missense	probably benign	0.01
R5298:Zfp507	UTSW	7	35,475,421 (GRCm39)	missense	probably damaging	0.99
R5602:Zfp507	UTSW	7	35,475,663 (GRCm39)	nonsense	probably null
R5707:Zfp507	UTSW	7	35,493,588 (GRCm39)	missense	probably damaging	1.00
R5785:Zfp507	UTSW	7	35,487,167 (GRCm39)	missense	probably benign	0.20
R6140:Zfp507	UTSW	7	35,493,613 (GRCm39)	missense	probably damaging	1.00
R6674:Zfp507	UTSW	7	35,494,159 (GRCm39)	missense	probably damaging	0.98
R6714:Zfp507	UTSW	7	35,487,152 (GRCm39)	missense	probably damaging	0.99
R7045:Zfp507	UTSW	7	35,494,978 (GRCm39)	missense	possibly damaging	0.56
R7334:Zfp507	UTSW	7	35,475,505 (GRCm39)	missense	probably damaging	1.00
R7365:Zfp507	UTSW	7	35,475,843 (GRCm39)	missense	unknown
R7569:Zfp507	UTSW	7	35,493,969 (GRCm39)	missense	probably damaging	0.99
R7662:Zfp507	UTSW	7	35,487,229 (GRCm39)	nonsense	probably null
R7846:Zfp507	UTSW	7	35,493,963 (GRCm39)	missense	probably damaging	1.00
R9100:Zfp507	UTSW	7	35,494,446 (GRCm39)	missense	probably benign	0.39
R9136:Zfp507	UTSW	7	35,475,883 (GRCm39)	missense	probably damaging	0.96
R9513:Zfp507	UTSW	7	35,475,573 (GRCm39)	missense	probably benign	0.00
Z1088:Zfp507	UTSW	7	35,493,702 (GRCm39)	missense	possibly damaging	0.88

Posted On

2012-12-06